Effect of disordered structure of Boron-containing calcium phosphates on their in vitro biodegradability

Sabrina Barheine, Satoshi Hayakawa, Christian Jäger, Yuki Shirosaki, Akiyoshi Osaka

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

This study proposes a new guideline for designing biodegradable apatite ceramics. Boron-containing hydroxyapatite (BHAp) particles were prepared by a high-temperature solid-state reaction processing method and were characterized in terms of their chemical composition, apatite lattice defects and in vitro biodegradability. Solid-state nuclear magnetic resonance analysis showed that boron-incorporation into hydroxyapatite (HAp) derived by thermo-chemical reactions between borate and calcium phosphate phases led to disordered phases (BCaP) of a CaO-P2O5-B2O3-OH system covering the crystalline HAp core. X-ray diffraction analysis indicated that the BCaP phase must consist mainly of a crystalline oxyboroapatite (OBAp) phase. An in vitro biodegradability test showed that BHAp degraded quicker than HAp or β-tricalcium phosphate. The biodegradability of BHAp particles can be controlled by boron incorporation into a HAp lattice leading to the formation of a disordered OBAp phase.

Original languageEnglish
Pages (from-to)2656-2662
Number of pages7
JournalJournal of the American Ceramic Society
Volume94
Issue number8
DOIs
Publication statusPublished - Aug 2011

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Calcium Phosphates
Boron
Biodegradability
Calcium phosphate
Durapatite
Hydroxyapatite
Apatites
phosphorus pentoxide
Apatite
Crystalline materials
Crystal defects
Solid state reactions
X ray diffraction analysis
Chemical reactions
Phosphates
Nuclear magnetic resonance

ASJC Scopus subject areas

  • Ceramics and Composites
  • Materials Chemistry

Cite this

Effect of disordered structure of Boron-containing calcium phosphates on their in vitro biodegradability. / Barheine, Sabrina; Hayakawa, Satoshi; Jäger, Christian; Shirosaki, Yuki; Osaka, Akiyoshi.

In: Journal of the American Ceramic Society, Vol. 94, No. 8, 08.2011, p. 2656-2662.

Research output: Contribution to journalArticle

Barheine, Sabrina ; Hayakawa, Satoshi ; Jäger, Christian ; Shirosaki, Yuki ; Osaka, Akiyoshi. / Effect of disordered structure of Boron-containing calcium phosphates on their in vitro biodegradability. In: Journal of the American Ceramic Society. 2011 ; Vol. 94, No. 8. pp. 2656-2662.
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