Effect of dietary magnesium supplementation on intralymphocytic free calcium and magnesium in stroke-prone spontaneously hypertensive rats

Minoru Adachi, Yasuo Nara, Masayuki Mano, Yukio Yamori

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The effects of dietary magnesium (Mg) supplementation on intralymphocytic free Ca2+ ([Ca2+]i) and Mg2+ ([Mg2+]i) were examined in the stroke-prone spontaneously hypertensive rats (SHRSP) at the age of 10 weeks. After 40 day Mg supplementation (0.8% Mg in the diet), systolic blood pressure (SBP) was significantly lower in Mg supplemented group (Mg group) than the control group (0.2% Mg). [Ca2+]i was significantly lower and [Mg2+]i was significantly higher in Mg group than in the control group. Further, [Ca2+]i was positively and [Mg2+]i was negatively correlated with SBP. These results suggest that dietary Mg supplementation modifies [Ca2+]i and [Mg2+]i, and modulates the development of hypertension.

Original languageEnglish
Pages (from-to)317-326
Number of pages10
JournalClinical and Experimental Hypertension
Volume16
Issue number3
DOIs
Publication statusPublished - Jan 1 1994

Keywords

  • Dietary magnesium
  • Intralymphocytic free calcium
  • Intralymphocytic free magnesium
  • Stroke-prone spontaneously hypertensive rats

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology

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