Effect of copper (II) ion against elongation behavior of amyloid β fibrils on liposome membranes

T. Shimanouchi, R. Onishi, N. Kitaura, H. Umakoshi, R. Kuboi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The fibril growth behavior of amyloid β protein (Aβ) on cell membranes is relating to the progression of Alzheimer's disease. This growth behavior of Aβ fibrils is sensitively affected by the metal ions, neurotransmitters, or bioreactive substrate. The inhibitory effect of those materials was quantitatively estimated from the viewpoints of "crystal growth". In a bulk aqueous solution, copper (II) ion showed the strong inhibitory effect on the growth of Aβ fibrils. Meanwhile, the addition of a closed-phospholipid bilayer membrane (liposome) could reduce the above inhibitory effect of copper (II) ion.

Original languageEnglish
Pages (from-to)101-108
Number of pages8
JournalCrystal Research and Technology
Volume47
Issue number1
DOIs
Publication statusPublished - Jan 1 2012
Externally publishedYes

Keywords

  • amyloid fibrils
  • copper ions
  • inhibitory
  • liposome

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

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