TY - JOUR
T1 - Effect of condensed tannins and related compounds on reverse transcriptase
AU - Kakiuchi, Nobuko
AU - Kusumoto, Ines T.
AU - Hattori, Masao
AU - Namba, Tsuneo
AU - Hatano, Tsutomu
AU - Okuda, Takuo
PY - 1991/12
Y1 - 1991/12
N2 - Inhibitory effects of 18 condensed tannins and related compounds on reverse transcriptase from an RNA tumour virus were examined in the presence of poly(riboadenylic acid) oligo(deoxythymidylic acid) ((rA)n(dT)12–18) or poly(ribocytidylic acid) oligo(deoxyguanylic acid) ((rC)n(dG)12–18) as a template‐primer. A potent inhibitory effect was found in galloylated monomers and oligomers as well as non‐galloylated tetramer, trimer and two of three dimers. The mode of the inhibition of one of them, procyanidin B‐2, was competitive with regard to the template‐primer.
AB - Inhibitory effects of 18 condensed tannins and related compounds on reverse transcriptase from an RNA tumour virus were examined in the presence of poly(riboadenylic acid) oligo(deoxythymidylic acid) ((rA)n(dT)12–18) or poly(ribocytidylic acid) oligo(deoxyguanylic acid) ((rC)n(dG)12–18) as a template‐primer. A potent inhibitory effect was found in galloylated monomers and oligomers as well as non‐galloylated tetramer, trimer and two of three dimers. The mode of the inhibition of one of them, procyanidin B‐2, was competitive with regard to the template‐primer.
KW - condensed tannins
KW - galloylated (−)‐epicatechin oligomers
KW - reverse transcriptase inhibitors
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U2 - 10.1002/ptr.2650050609
DO - 10.1002/ptr.2650050609
M3 - Article
AN - SCOPUS:0026043722
SN - 0951-418X
VL - 5
SP - 270
EP - 272
JO - Phytotherapy Research
JF - Phytotherapy Research
IS - 6
ER -