Effect of condensed tannins and related compounds on reverse transcriptase

Nobuko Kakiuchi, Ines T. Kusumoto, Masao Hattori, Tsuneo Namba, Tsutomu Hatano, Takuo Okuda

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29 Citations (Scopus)

Abstract

Inhibitory effects of 18 condensed tannins and related compounds on reverse transcriptase from an RNA tumour virus were examined in the presence of poly(riboadenylic acid) oligo(deoxythymidylic acid) ((rA)n(dT)12–18) or poly(ribocytidylic acid) oligo(deoxyguanylic acid) ((rC)n(dG)12–18) as a template‐primer. A potent inhibitory effect was found in galloylated monomers and oligomers as well as non‐galloylated tetramer, trimer and two of three dimers. The mode of the inhibition of one of them, procyanidin B‐2, was competitive with regard to the template‐primer.

Original languageEnglish
Pages (from-to)270-272
Number of pages3
JournalPhytotherapy Research
Volume5
Issue number6
DOIs
Publication statusPublished - Dec 1991

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Keywords

  • condensed tannins
  • galloylated (−)‐epicatechin oligomers
  • reverse transcriptase inhibitors

ASJC Scopus subject areas

  • Pharmacology

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