Effect of Chronic Administration of Haloperidol (Intermittently) and Haloperidol‐Decanoate (Continuously) on D2 Dopamine and Muscarinic Cholinergic Receptors and on Carbachol‐Stimulated Phosphoinositide Hydrolysis in the Rat Striatum

Kazufumi Akiyama, Mitsumoto Sato, Norihito Yamada, Saburo Otsuki

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Abstract: It has been reported that apomorphine‐induced stereotypy is sensitized after a chronic intermittent administration of haloperidol (HPD), but not after a chronic continuous exposure to haloperidol‐decanoate (HPD‐D). The present study was undertaken to investigate changes in the D2 dopamine and muscarinic receptors in the ratstriatum after the administration of HPD intermittently and HPD‐D continuously. The number of striatal [3H] spiperone binding sites increased significantly after HPD‐D, but did not change after HPD. Neither the number of [3H](–)QNB binding sites nor carbachol‐stimulated phosphoinositide hydrolysis changed after either HPD or HPD‐D. These results indicate that the increase in striatal D2 receptors in rats administered HPD‐D represents behavioral and biochemical tolerance, and that neither the D2 dopamine receptor supersensitivity nor muscarinic receptor hyposensitivity underlies sensitization of apomorphine‐induced stereotypy.

Original languageEnglish
Pages (from-to)311-320
Number of pages10
JournalPsychiatry and Clinical Neurosciences
Volume41
Issue number2
DOIs
Publication statusPublished - Jun 1987

Keywords

  • dopamine receptor
  • haloperidol
  • haloperidol‐decanoate
  • muscarinic receptor
  • phosphoinositide
  • tardive dyskinesia

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

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