Effect of ceruletide on epileptogenesis in amygdaloid kindled rats

Yoshitaka Yamamoto, Toshifumi Itano, Osamu Miyamoto, Masaaki Tokuda, Hideki Matsui, Najma A. Janjua, Hiroshi Suwaki, Yasushi Okada, Tetsuro Negi, Tetuhide H. Murakami, Osamu Hatase

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5 Citations (Scopus)

Abstract

The inhibitory effects of ceruletide (CLT), a cholecystokinin-8 (CCK)-like, peptide, were investigated in the epileptogenesis in the amygdaloid kindled rats. Lower doses of CLT (20-80 μg/kg) inhibited the progression of kindling process. After acquiring C5 stage, a higher dose (160 μg.kg) was required to suppress the seizure susceptibility. These results, in light of several previous studies showing no serious side effects, suggest that CLT might be useful as an anti-epileptogenic agent for clinical usage.

Original languageEnglish
Pages (from-to)353-356
Number of pages4
JournalBrain Research
Volume630
Issue number1-2
DOIs
Publication statusPublished - Dec 10 1993

Keywords

  • CCK
  • Ceruletide
  • Epilepsy
  • Kindling

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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    Yamamoto, Y., Itano, T., Miyamoto, O., Tokuda, M., Matsui, H., Janjua, N. A., Suwaki, H., Okada, Y., Negi, T., Murakami, T. H., & Hatase, O. (1993). Effect of ceruletide on epileptogenesis in amygdaloid kindled rats. Brain Research, 630(1-2), 353-356. https://doi.org/10.1016/0006-8993(93)90678-G