Effect of carrageenan-induced acute peripheral inflammation on the electrolyte disposition to cerebrospinal fluid in rats

Kentaro Kono, Atsuyoshi Okada, Atsuko Ishikawa, Tetsuya Aiba

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

To clarify whether peripheral inflammation has a remote effect on the central nervous system, the electrolyte disposition between the circulating blood and central nervous system was evaluated in rats with carrageenan-induced acute peripheral inflammation (API). λ-Carrageenan was subcutaneously injected in the hind paw of the rat, and lithium was utilized as a surrogate marker of sodium. When the plasma and cerebrospinal fluid (CSF) concentrations of lithium were examined following lithium being intravenously administered, it was revealed that the CSF concentration of lithium in API rats is reduced compared to that in normal rats, while the plasma concentration profile of lithium in API rats is indistinguishable from that in normal rats. The pharmacokinetic analysis showed that the lithium disposition from the plasma to CSF markedly decreased by 35.8% in API rats compared to that in normal rats. On the other hand, when lithium was immediately administered into the lateral ventricle, its elimination profiles in CSF were not different between normal and API rats. It is therefore probable that the lithium disposition from the plasma to CSF alters in API rats, reflecting the entry process of electrolytes from the circulating blood to brain tissue being suppressed in response to peripheral inflammation.

Original languageEnglish
Pages (from-to)1829-1834
Number of pages6
JournalBiological and Pharmaceutical Bulletin
Volume36
Issue number11
DOIs
Publication statusPublished - Nov 2013

Keywords

  • Carrageenan
  • Cerebrospinal fluid
  • Lithium
  • Microdialysis
  • Peripheral inflammation

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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