Effect of carrageenan-induced acute peripheral inflammation on the electrolyte disposition to cerebrospinal fluid in rats

Kentaro Kono, Atsuyoshi Okada, Atsuko Ishikawa, Tetsuya Aiba

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

To clarify whether peripheral inflammation has a remote effect on the central nervous system, the electrolyte disposition between the circulating blood and central nervous system was evaluated in rats with carrageenan-induced acute peripheral inflammation (API). λ-Carrageenan was subcutaneously injected in the hind paw of the rat, and lithium was utilized as a surrogate marker of sodium. When the plasma and cerebrospinal fluid (CSF) concentrations of lithium were examined following lithium being intravenously administered, it was revealed that the CSF concentration of lithium in API rats is reduced compared to that in normal rats, while the plasma concentration profile of lithium in API rats is indistinguishable from that in normal rats. The pharmacokinetic analysis showed that the lithium disposition from the plasma to CSF markedly decreased by 35.8% in API rats compared to that in normal rats. On the other hand, when lithium was immediately administered into the lateral ventricle, its elimination profiles in CSF were not different between normal and API rats. It is therefore probable that the lithium disposition from the plasma to CSF alters in API rats, reflecting the entry process of electrolytes from the circulating blood to brain tissue being suppressed in response to peripheral inflammation.

Original languageEnglish
Pages (from-to)1829-1834
Number of pages6
JournalBiological and Pharmaceutical Bulletin
Volume36
Issue number11
DOIs
Publication statusPublished - Nov 2013

Fingerprint

Carrageenan
Electrolytes
Cerebrospinal Fluid
Lithium
Inflammation
Central Nervous System
Lateral Ventricles
Pharmacokinetics
Biomarkers
Sodium

Keywords

  • Carrageenan
  • Cerebrospinal fluid
  • Lithium
  • Microdialysis
  • Peripheral inflammation

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

Cite this

Effect of carrageenan-induced acute peripheral inflammation on the electrolyte disposition to cerebrospinal fluid in rats. / Kono, Kentaro; Okada, Atsuyoshi; Ishikawa, Atsuko; Aiba, Tetsuya.

In: Biological and Pharmaceutical Bulletin, Vol. 36, No. 11, 11.2013, p. 1829-1834.

Research output: Contribution to journalArticle

@article{491a12aa7c84428baa1bcadadb021968,
title = "Effect of carrageenan-induced acute peripheral inflammation on the electrolyte disposition to cerebrospinal fluid in rats",
abstract = "To clarify whether peripheral inflammation has a remote effect on the central nervous system, the electrolyte disposition between the circulating blood and central nervous system was evaluated in rats with carrageenan-induced acute peripheral inflammation (API). λ-Carrageenan was subcutaneously injected in the hind paw of the rat, and lithium was utilized as a surrogate marker of sodium. When the plasma and cerebrospinal fluid (CSF) concentrations of lithium were examined following lithium being intravenously administered, it was revealed that the CSF concentration of lithium in API rats is reduced compared to that in normal rats, while the plasma concentration profile of lithium in API rats is indistinguishable from that in normal rats. The pharmacokinetic analysis showed that the lithium disposition from the plasma to CSF markedly decreased by 35.8{\%} in API rats compared to that in normal rats. On the other hand, when lithium was immediately administered into the lateral ventricle, its elimination profiles in CSF were not different between normal and API rats. It is therefore probable that the lithium disposition from the plasma to CSF alters in API rats, reflecting the entry process of electrolytes from the circulating blood to brain tissue being suppressed in response to peripheral inflammation.",
keywords = "Carrageenan, Cerebrospinal fluid, Lithium, Microdialysis, Peripheral inflammation",
author = "Kentaro Kono and Atsuyoshi Okada and Atsuko Ishikawa and Tetsuya Aiba",
year = "2013",
month = "11",
doi = "10.1248/bpb.b13-00531",
language = "English",
volume = "36",
pages = "1829--1834",
journal = "Biological and Pharmaceutical Bulletin",
issn = "0918-6158",
publisher = "Pharmaceutical Society of Japan",
number = "11",

}

TY - JOUR

T1 - Effect of carrageenan-induced acute peripheral inflammation on the electrolyte disposition to cerebrospinal fluid in rats

AU - Kono, Kentaro

AU - Okada, Atsuyoshi

AU - Ishikawa, Atsuko

AU - Aiba, Tetsuya

PY - 2013/11

Y1 - 2013/11

N2 - To clarify whether peripheral inflammation has a remote effect on the central nervous system, the electrolyte disposition between the circulating blood and central nervous system was evaluated in rats with carrageenan-induced acute peripheral inflammation (API). λ-Carrageenan was subcutaneously injected in the hind paw of the rat, and lithium was utilized as a surrogate marker of sodium. When the plasma and cerebrospinal fluid (CSF) concentrations of lithium were examined following lithium being intravenously administered, it was revealed that the CSF concentration of lithium in API rats is reduced compared to that in normal rats, while the plasma concentration profile of lithium in API rats is indistinguishable from that in normal rats. The pharmacokinetic analysis showed that the lithium disposition from the plasma to CSF markedly decreased by 35.8% in API rats compared to that in normal rats. On the other hand, when lithium was immediately administered into the lateral ventricle, its elimination profiles in CSF were not different between normal and API rats. It is therefore probable that the lithium disposition from the plasma to CSF alters in API rats, reflecting the entry process of electrolytes from the circulating blood to brain tissue being suppressed in response to peripheral inflammation.

AB - To clarify whether peripheral inflammation has a remote effect on the central nervous system, the electrolyte disposition between the circulating blood and central nervous system was evaluated in rats with carrageenan-induced acute peripheral inflammation (API). λ-Carrageenan was subcutaneously injected in the hind paw of the rat, and lithium was utilized as a surrogate marker of sodium. When the plasma and cerebrospinal fluid (CSF) concentrations of lithium were examined following lithium being intravenously administered, it was revealed that the CSF concentration of lithium in API rats is reduced compared to that in normal rats, while the plasma concentration profile of lithium in API rats is indistinguishable from that in normal rats. The pharmacokinetic analysis showed that the lithium disposition from the plasma to CSF markedly decreased by 35.8% in API rats compared to that in normal rats. On the other hand, when lithium was immediately administered into the lateral ventricle, its elimination profiles in CSF were not different between normal and API rats. It is therefore probable that the lithium disposition from the plasma to CSF alters in API rats, reflecting the entry process of electrolytes from the circulating blood to brain tissue being suppressed in response to peripheral inflammation.

KW - Carrageenan

KW - Cerebrospinal fluid

KW - Lithium

KW - Microdialysis

KW - Peripheral inflammation

UR - http://www.scopus.com/inward/record.url?scp=84888585540&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84888585540&partnerID=8YFLogxK

U2 - 10.1248/bpb.b13-00531

DO - 10.1248/bpb.b13-00531

M3 - Article

C2 - 24189427

AN - SCOPUS:84888585540

VL - 36

SP - 1829

EP - 1834

JO - Biological and Pharmaceutical Bulletin

JF - Biological and Pharmaceutical Bulletin

SN - 0918-6158

IS - 11

ER -