Effect of capsaicin-evoked jaw-muscle pain on intramuscular blood-flow

Taro Arima, Lars Arendt-Nielsen, Shougo Minagi, Peter Svensson

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Aim: To investigate effect of capsaicin-evoked masseter-muscle pain on intramuscular blood-flow (BF) at rest and during contractions. Methods: Eight healthy men (22-31 years) participated. BF was measured with Laser Doppler (Moor Instruments, UK) using a single-fibre probe inserted into the right masseter. Three BF probes were attached to the skin above right and left masseter and the right-middle finger. Subjects performed 30 s isometric contractions at 5%, 15%, and 25% of maximal voluntary contraction. After the contractions, capsaicin (0.1 mL, 100 μg/mL) was injected into the right masseter close to the fibre probe. When the pain sensation had disappeared, the series of submaximal contractions were repeated. BF data were sampled continuously, processed in 10 s bins, and analyzed with repeated-measures ANOVAs. Results: Intramuscular BF significantly increased immediately after capsaicin injection (P <0.050) and rapidly (30 s) decreased to pre-injection values. A significant increase in cutaneous BF above the right masseter was observed (P <0.050) and lasted for 10 min, while a significant BF decrease in the finger (P <0.050) was observed. The contractions were associated with increases in intramuscular BF before and after the injection (P <0.022) and the contraction levels were also associated with increase in intramuscular BF before injection (P = 0.008) but not after injection (P = 0.314). Conclusions: This study demonstrated BF increased by muscle contraction but failed to show effects of contraction levels on BF in a muscle exposed to nociceptive stimuli. Neurogenic inflammation in muscles could possibly be mediated via antidromical effects and local release of vasoactive substances. The decreased BF in the finger could be due to involvement of central regulatory mechanisms.

Original languageEnglish
Pages (from-to)241-249
Number of pages9
JournalArchives of Oral Biology
Volume54
Issue number3
DOIs
Publication statusPublished - Mar 2009

Fingerprint

Capsaicin
Myalgia
Jaw
Injections
Fingers
Neurogenic Inflammation
Masseter Muscle
Muscles
Skin
Isometric Contraction
Muscle Contraction
Analysis of Variance
Lasers

Keywords

  • Bite force
  • Capsaicin
  • Intramuscular blood flow
  • Masticatory muscles

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Cell Biology
  • Dentistry(all)
  • Medicine(all)

Cite this

Effect of capsaicin-evoked jaw-muscle pain on intramuscular blood-flow. / Arima, Taro; Arendt-Nielsen, Lars; Minagi, Shougo; Svensson, Peter.

In: Archives of Oral Biology, Vol. 54, No. 3, 03.2009, p. 241-249.

Research output: Contribution to journalArticle

Arima, Taro ; Arendt-Nielsen, Lars ; Minagi, Shougo ; Svensson, Peter. / Effect of capsaicin-evoked jaw-muscle pain on intramuscular blood-flow. In: Archives of Oral Biology. 2009 ; Vol. 54, No. 3. pp. 241-249.
@article{e46454b0bf9c4e32bf5842b886cc7707,
title = "Effect of capsaicin-evoked jaw-muscle pain on intramuscular blood-flow",
abstract = "Aim: To investigate effect of capsaicin-evoked masseter-muscle pain on intramuscular blood-flow (BF) at rest and during contractions. Methods: Eight healthy men (22-31 years) participated. BF was measured with Laser Doppler (Moor Instruments, UK) using a single-fibre probe inserted into the right masseter. Three BF probes were attached to the skin above right and left masseter and the right-middle finger. Subjects performed 30 s isometric contractions at 5{\%}, 15{\%}, and 25{\%} of maximal voluntary contraction. After the contractions, capsaicin (0.1 mL, 100 μg/mL) was injected into the right masseter close to the fibre probe. When the pain sensation had disappeared, the series of submaximal contractions were repeated. BF data were sampled continuously, processed in 10 s bins, and analyzed with repeated-measures ANOVAs. Results: Intramuscular BF significantly increased immediately after capsaicin injection (P <0.050) and rapidly (30 s) decreased to pre-injection values. A significant increase in cutaneous BF above the right masseter was observed (P <0.050) and lasted for 10 min, while a significant BF decrease in the finger (P <0.050) was observed. The contractions were associated with increases in intramuscular BF before and after the injection (P <0.022) and the contraction levels were also associated with increase in intramuscular BF before injection (P = 0.008) but not after injection (P = 0.314). Conclusions: This study demonstrated BF increased by muscle contraction but failed to show effects of contraction levels on BF in a muscle exposed to nociceptive stimuli. Neurogenic inflammation in muscles could possibly be mediated via antidromical effects and local release of vasoactive substances. The decreased BF in the finger could be due to involvement of central regulatory mechanisms.",
keywords = "Bite force, Capsaicin, Intramuscular blood flow, Masticatory muscles",
author = "Taro Arima and Lars Arendt-Nielsen and Shougo Minagi and Peter Svensson",
year = "2009",
month = "3",
doi = "10.1016/j.archoralbio.2008.11.005",
language = "English",
volume = "54",
pages = "241--249",
journal = "Archives of Oral Biology",
issn = "0003-9969",
publisher = "Elsevier Limited",
number = "3",

}

TY - JOUR

T1 - Effect of capsaicin-evoked jaw-muscle pain on intramuscular blood-flow

AU - Arima, Taro

AU - Arendt-Nielsen, Lars

AU - Minagi, Shougo

AU - Svensson, Peter

PY - 2009/3

Y1 - 2009/3

N2 - Aim: To investigate effect of capsaicin-evoked masseter-muscle pain on intramuscular blood-flow (BF) at rest and during contractions. Methods: Eight healthy men (22-31 years) participated. BF was measured with Laser Doppler (Moor Instruments, UK) using a single-fibre probe inserted into the right masseter. Three BF probes were attached to the skin above right and left masseter and the right-middle finger. Subjects performed 30 s isometric contractions at 5%, 15%, and 25% of maximal voluntary contraction. After the contractions, capsaicin (0.1 mL, 100 μg/mL) was injected into the right masseter close to the fibre probe. When the pain sensation had disappeared, the series of submaximal contractions were repeated. BF data were sampled continuously, processed in 10 s bins, and analyzed with repeated-measures ANOVAs. Results: Intramuscular BF significantly increased immediately after capsaicin injection (P <0.050) and rapidly (30 s) decreased to pre-injection values. A significant increase in cutaneous BF above the right masseter was observed (P <0.050) and lasted for 10 min, while a significant BF decrease in the finger (P <0.050) was observed. The contractions were associated with increases in intramuscular BF before and after the injection (P <0.022) and the contraction levels were also associated with increase in intramuscular BF before injection (P = 0.008) but not after injection (P = 0.314). Conclusions: This study demonstrated BF increased by muscle contraction but failed to show effects of contraction levels on BF in a muscle exposed to nociceptive stimuli. Neurogenic inflammation in muscles could possibly be mediated via antidromical effects and local release of vasoactive substances. The decreased BF in the finger could be due to involvement of central regulatory mechanisms.

AB - Aim: To investigate effect of capsaicin-evoked masseter-muscle pain on intramuscular blood-flow (BF) at rest and during contractions. Methods: Eight healthy men (22-31 years) participated. BF was measured with Laser Doppler (Moor Instruments, UK) using a single-fibre probe inserted into the right masseter. Three BF probes were attached to the skin above right and left masseter and the right-middle finger. Subjects performed 30 s isometric contractions at 5%, 15%, and 25% of maximal voluntary contraction. After the contractions, capsaicin (0.1 mL, 100 μg/mL) was injected into the right masseter close to the fibre probe. When the pain sensation had disappeared, the series of submaximal contractions were repeated. BF data were sampled continuously, processed in 10 s bins, and analyzed with repeated-measures ANOVAs. Results: Intramuscular BF significantly increased immediately after capsaicin injection (P <0.050) and rapidly (30 s) decreased to pre-injection values. A significant increase in cutaneous BF above the right masseter was observed (P <0.050) and lasted for 10 min, while a significant BF decrease in the finger (P <0.050) was observed. The contractions were associated with increases in intramuscular BF before and after the injection (P <0.022) and the contraction levels were also associated with increase in intramuscular BF before injection (P = 0.008) but not after injection (P = 0.314). Conclusions: This study demonstrated BF increased by muscle contraction but failed to show effects of contraction levels on BF in a muscle exposed to nociceptive stimuli. Neurogenic inflammation in muscles could possibly be mediated via antidromical effects and local release of vasoactive substances. The decreased BF in the finger could be due to involvement of central regulatory mechanisms.

KW - Bite force

KW - Capsaicin

KW - Intramuscular blood flow

KW - Masticatory muscles

UR - http://www.scopus.com/inward/record.url?scp=58849127305&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58849127305&partnerID=8YFLogxK

U2 - 10.1016/j.archoralbio.2008.11.005

DO - 10.1016/j.archoralbio.2008.11.005

M3 - Article

C2 - 19128796

AN - SCOPUS:58849127305

VL - 54

SP - 241

EP - 249

JO - Archives of Oral Biology

JF - Archives of Oral Biology

SN - 0003-9969

IS - 3

ER -