Effect of Brn-3a deficiency on CGRP-immunoreactivity in the dorsal root ganglion

Hiroyuki Ichikawa, Tomoichiro Yamaai, Zeqian Mo, Mengqing Xiang, Tomosada Sugimoto

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Immunohistochemistry for calcitonin gene-related peptide (CGRP) was performed on the dorsal root ganglion (DRG) and spinal cord in wildtype and knockout mice for Brn-3a. CGRP-immunoreactive (-IR) neurons were abundant in the DRG of wildtype, heterozygous and knockout mice. Cell size analysis revealed that CGRP-IR neurons were of various sizes in wildtype and heterozygous mice. In the knockout mice, however, most of CGRP-IR neurons were small. In the spinal cord of knockout mice, the number of CGRP-IR fibers increased in the dorsal column but decreased in the deep part of the dorsal horn. The loss of Brn-3a may have different effects on CGRP-IR expression in small and large DRG neurons.

Original languageEnglish
Pages (from-to)409-412
Number of pages4
JournalNeuroReport
Volume13
Issue number4
Publication statusPublished - Mar 25 2002

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Calcitonin Gene-Related Peptide
Spinal Ganglia
Knockout Mice
Neurons
Spinal Cord
Cell Size
Immunohistochemistry

Keywords

  • Brn-3a
  • Calcitonin gene-related peptide
  • Dorsal root ganglion
  • Immunohistochemistry
  • Knockout mouse

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Ichikawa, H., Yamaai, T., Mo, Z., Xiang, M., & Sugimoto, T. (2002). Effect of Brn-3a deficiency on CGRP-immunoreactivity in the dorsal root ganglion. NeuroReport, 13(4), 409-412.

Effect of Brn-3a deficiency on CGRP-immunoreactivity in the dorsal root ganglion. / Ichikawa, Hiroyuki; Yamaai, Tomoichiro; Mo, Zeqian; Xiang, Mengqing; Sugimoto, Tomosada.

In: NeuroReport, Vol. 13, No. 4, 25.03.2002, p. 409-412.

Research output: Contribution to journalArticle

Ichikawa, H, Yamaai, T, Mo, Z, Xiang, M & Sugimoto, T 2002, 'Effect of Brn-3a deficiency on CGRP-immunoreactivity in the dorsal root ganglion', NeuroReport, vol. 13, no. 4, pp. 409-412.
Ichikawa H, Yamaai T, Mo Z, Xiang M, Sugimoto T. Effect of Brn-3a deficiency on CGRP-immunoreactivity in the dorsal root ganglion. NeuroReport. 2002 Mar 25;13(4):409-412.
Ichikawa, Hiroyuki ; Yamaai, Tomoichiro ; Mo, Zeqian ; Xiang, Mengqing ; Sugimoto, Tomosada. / Effect of Brn-3a deficiency on CGRP-immunoreactivity in the dorsal root ganglion. In: NeuroReport. 2002 ; Vol. 13, No. 4. pp. 409-412.
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