TY - JOUR
T1 - Effect of Brn-3a deficiency on CGRP-immunoreactivity in the dorsal root ganglion
AU - Ichikawa, Hiroyuki
AU - Yamaai, Tomoichiro
AU - Mo, Zeqian
AU - Xiang, Mengqing
AU - Sugimoto, Tomosada
PY - 2002/3/25
Y1 - 2002/3/25
N2 - Immunohistochemistry for calcitonin gene-related peptide (CGRP) was performed on the dorsal root ganglion (DRG) and spinal cord in wildtype and knockout mice for Brn-3a. CGRP-immunoreactive (-IR) neurons were abundant in the DRG of wildtype, heterozygous and knockout mice. Cell size analysis revealed that CGRP-IR neurons were of various sizes in wildtype and heterozygous mice. In the knockout mice, however, most of CGRP-IR neurons were small. In the spinal cord of knockout mice, the number of CGRP-IR fibers increased in the dorsal column but decreased in the deep part of the dorsal horn. The loss of Brn-3a may have different effects on CGRP-IR expression in small and large DRG neurons.
AB - Immunohistochemistry for calcitonin gene-related peptide (CGRP) was performed on the dorsal root ganglion (DRG) and spinal cord in wildtype and knockout mice for Brn-3a. CGRP-immunoreactive (-IR) neurons were abundant in the DRG of wildtype, heterozygous and knockout mice. Cell size analysis revealed that CGRP-IR neurons were of various sizes in wildtype and heterozygous mice. In the knockout mice, however, most of CGRP-IR neurons were small. In the spinal cord of knockout mice, the number of CGRP-IR fibers increased in the dorsal column but decreased in the deep part of the dorsal horn. The loss of Brn-3a may have different effects on CGRP-IR expression in small and large DRG neurons.
KW - Brn-3a
KW - Calcitonin gene-related peptide
KW - Dorsal root ganglion
KW - Immunohistochemistry
KW - Knockout mouse
UR - http://www.scopus.com/inward/record.url?scp=0037171010&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037171010&partnerID=8YFLogxK
U2 - 10.1097/00001756-200203250-00009
DO - 10.1097/00001756-200203250-00009
M3 - Article
C2 - 11930150
AN - SCOPUS:0037171010
VL - 13
SP - 409
EP - 412
JO - NeuroReport
JF - NeuroReport
SN - 0959-4965
IS - 4
ER -