Abstract
Immunohistochemistry for calcitonin gene-related peptide (CGRP) was performed on the dorsal root ganglion (DRG) and spinal cord in wildtype and knockout mice for Brn-3a. CGRP-immunoreactive (-IR) neurons were abundant in the DRG of wildtype, heterozygous and knockout mice. Cell size analysis revealed that CGRP-IR neurons were of various sizes in wildtype and heterozygous mice. In the knockout mice, however, most of CGRP-IR neurons were small. In the spinal cord of knockout mice, the number of CGRP-IR fibers increased in the dorsal column but decreased in the deep part of the dorsal horn. The loss of Brn-3a may have different effects on CGRP-IR expression in small and large DRG neurons.
| Original language | English |
|---|---|
| Pages (from-to) | 409-412 |
| Number of pages | 4 |
| Journal | NeuroReport |
| Volume | 13 |
| Issue number | 4 |
| Publication status | Published - Mar 25 2002 |
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Keywords
- Brn-3a
- Calcitonin gene-related peptide
- Dorsal root ganglion
- Immunohistochemistry
- Knockout mouse
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Effect of Brn-3a deficiency on CGRP-immunoreactivity in the dorsal root ganglion. / Ichikawa, Hiroyuki; Yamaai, Tomoichiro; Mo, Zeqian; Xiang, Mengqing; Sugimoto, Tomosada.
In: NeuroReport, Vol. 13, No. 4, 25.03.2002, p. 409-412.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of Brn-3a deficiency on CGRP-immunoreactivity in the dorsal root ganglion
AU - Ichikawa, Hiroyuki
AU - Yamaai, Tomoichiro
AU - Mo, Zeqian
AU - Xiang, Mengqing
AU - Sugimoto, Tomosada
PY - 2002/3/25
Y1 - 2002/3/25
N2 - Immunohistochemistry for calcitonin gene-related peptide (CGRP) was performed on the dorsal root ganglion (DRG) and spinal cord in wildtype and knockout mice for Brn-3a. CGRP-immunoreactive (-IR) neurons were abundant in the DRG of wildtype, heterozygous and knockout mice. Cell size analysis revealed that CGRP-IR neurons were of various sizes in wildtype and heterozygous mice. In the knockout mice, however, most of CGRP-IR neurons were small. In the spinal cord of knockout mice, the number of CGRP-IR fibers increased in the dorsal column but decreased in the deep part of the dorsal horn. The loss of Brn-3a may have different effects on CGRP-IR expression in small and large DRG neurons.
AB - Immunohistochemistry for calcitonin gene-related peptide (CGRP) was performed on the dorsal root ganglion (DRG) and spinal cord in wildtype and knockout mice for Brn-3a. CGRP-immunoreactive (-IR) neurons were abundant in the DRG of wildtype, heterozygous and knockout mice. Cell size analysis revealed that CGRP-IR neurons were of various sizes in wildtype and heterozygous mice. In the knockout mice, however, most of CGRP-IR neurons were small. In the spinal cord of knockout mice, the number of CGRP-IR fibers increased in the dorsal column but decreased in the deep part of the dorsal horn. The loss of Brn-3a may have different effects on CGRP-IR expression in small and large DRG neurons.
KW - Brn-3a
KW - Calcitonin gene-related peptide
KW - Dorsal root ganglion
KW - Immunohistochemistry
KW - Knockout mouse
UR - http://www.scopus.com/inward/record.url?scp=0037171010&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037171010&partnerID=8YFLogxK
M3 - Article
VL - 13
SP - 409
EP - 412
JO - NeuroReport
JF - NeuroReport
SN - 0959-4965
IS - 4
ER -