Effect of Badoushuang on progressive glomerular sclerosis in rats with 7/8 nephrectomy

Effect of Badoushuang (Semen crotonis pulveratum) was studied in the 7/8 neph-rectomied rats, which we could establish as progressive glomerulosclerosis model in rats (Jap J Nephrol 32 : 127, 1990). Badoushuang was administered into rats orally 60 mg/kg/day every day after 7/8 nephrectomy. As controls 7/8 nephrectomied rats were used. No adverse effect of Badoushuang were noted during 8 weeks of observation periods. Administration of Badoushuang, in rats with a remnant kidney, decreases urinary protein and lowers blood pressure, keeps creatinine clearance and lowers serum creatinine level and BUN. Morphologically glomerular hypertrophy, crescent formation and sclerosis were less in experimental treated rats. These results suggest Badoushuang ameliorates the progressive kidney disease of rats with subtotal renal ablation. Further study is necessary to clarify the effect of Basoushuang on progressive glomerular sclerosis.