Abstract
Effect of Badoushuang (Semen crotonis pulveratum) was studied in the 7/8 neph-rectomied rats, which we could establish as progressive glomerulosclerosis model in rats (Jap J Nephrol 32 : 127, 1990). Badoushuang was administered into rats orally 60 mg/kg/day every day after 7/8 nephrectomy. As controls 7/8 nephrectomied rats were used. No adverse effect of Badoushuang were noted during 8 weeks of observation periods. Administration of Badoushuang, in rats with a remnant kidney, decreases urinary protein and lowers blood pressure, keeps creatinine clearance and lowers serum creatinine level and BUN. Morphologically glomerular hypertrophy, crescent formation and sclerosis were less in experimental treated rats. These results suggest Badoushuang ameliorates the progressive kidney disease of rats with subtotal renal ablation. Further study is necessary to clarify the effect of Basoushuang on progressive glomerular sclerosis.
| Original language | English |
|---|---|
| Pages (from-to) | 743-751 |
| Number of pages | 9 |
| Journal | The Japanese Journal of Nephrology |
| Volume | 33 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Jan 1 1991 |
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Keywords
- Badoushuang
- glomerulosclerosis
- renal ablation
- renal failure
- therapy
ASJC Scopus subject areas
- Nephrology
Cite this
Effect of Badoushuang on progressive glomerular sclerosis in rats with 7/8 nephrectomy. / Zheng, Long Zhu; Makino, Hirofumi; Ota, Zensuke; Yoshifusa, Hiroto.
In: The Japanese Journal of Nephrology, Vol. 33, No. 8, 01.01.1991, p. 743-751.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of Badoushuang on progressive glomerular sclerosis in rats with 7/8 nephrectomy
AU - Zheng, Long Zhu
AU - Makino, Hirofumi
AU - Ota, Zensuke
AU - Yoshifusa, Hiroto
PY - 1991/1/1
Y1 - 1991/1/1
N2 - Effect of Badoushuang (Semen crotonis pulveratum) was studied in the 7/8 neph-rectomied rats, which we could establish as progressive glomerulosclerosis model in rats (Jap J Nephrol 32 : 127, 1990). Badoushuang was administered into rats orally 60 mg/kg/day every day after 7/8 nephrectomy. As controls 7/8 nephrectomied rats were used. No adverse effect of Badoushuang were noted during 8 weeks of observation periods. Administration of Badoushuang, in rats with a remnant kidney, decreases urinary protein and lowers blood pressure, keeps creatinine clearance and lowers serum creatinine level and BUN. Morphologically glomerular hypertrophy, crescent formation and sclerosis were less in experimental treated rats. These results suggest Badoushuang ameliorates the progressive kidney disease of rats with subtotal renal ablation. Further study is necessary to clarify the effect of Basoushuang on progressive glomerular sclerosis.
AB - Effect of Badoushuang (Semen crotonis pulveratum) was studied in the 7/8 neph-rectomied rats, which we could establish as progressive glomerulosclerosis model in rats (Jap J Nephrol 32 : 127, 1990). Badoushuang was administered into rats orally 60 mg/kg/day every day after 7/8 nephrectomy. As controls 7/8 nephrectomied rats were used. No adverse effect of Badoushuang were noted during 8 weeks of observation periods. Administration of Badoushuang, in rats with a remnant kidney, decreases urinary protein and lowers blood pressure, keeps creatinine clearance and lowers serum creatinine level and BUN. Morphologically glomerular hypertrophy, crescent formation and sclerosis were less in experimental treated rats. These results suggest Badoushuang ameliorates the progressive kidney disease of rats with subtotal renal ablation. Further study is necessary to clarify the effect of Basoushuang on progressive glomerular sclerosis.
KW - Badoushuang
KW - glomerulosclerosis
KW - renal ablation
KW - renal failure
KW - therapy
UR - http://www.scopus.com/inward/record.url?scp=0026096212&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026096212&partnerID=8YFLogxK
U2 - 10.14842/jpnjnephrol1959.33.743
DO - 10.14842/jpnjnephrol1959.33.743
M3 - Article
C2 - 1770634
AN - SCOPUS:0026096212
VL - 33
SP - 743
EP - 751
JO - Japanese Journal of Nephrology
JF - Japanese Journal of Nephrology
SN - 0385-2385
IS - 8
ER -