Effect of antibodies against intercellular adhesion molecule-1, B7, and CD40 on interleukin-18-treated human mixed lymphocyte reaction

Hideo Kohka Takahashi; Hiromi Iwagaki; Ryuji Tamura; Takahito Yagi; Tadashi Yoshino; Shuji Mori; Noriaki Tanaka; Masahiro Nishibori

doi:10.1254/jphs.SC0040167

Effect of antibodies against intercellular adhesion molecule-1, B7, and CD40 on interleukin-18-treated human mixed lymphocyte reaction

Hideo Kohka Takahashi, Hiromi Iwagaki, Ryuji Tamura, Takahito Yagi, Tadashi Yoshino, Shuji Mori, Noriaki Tanaka, Masahiro Nishibori

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

The interleukin (IL)-18 level in plasma is elevated during the acute rejection after organ transplantation. IL-18 elicits adhesion molecule expression as well as interferon-γ/IL-12 production and T-cell proliferation in the human mixed lymphocyte reaction, an in vitro model of acute rejection. We examined whether antibodies (Abs) against intercellular adhesion molecule (ICAM)-1, B7, CD40, and CD40, ligand (CD40L) affect the cytokine production and T-cell proliferation. Anti-ICAM-1 and BV Abs suppressed the cytokine production, while all Abs inhibited T-cell proliferation. ICAM-1 and B7 as well as CD40 may play different roles in the acute rejection.

Original language	English
Pages (from-to)	447-450
Number of pages	4
Journal	Journal of Pharmacological Sciences
Volume	97
Issue number	3
DOIs	https://doi.org/10.1254/jphs.SC0040167
Publication status	Published - Mar 2005

Keywords

Adhesion molecule
Interleukin-18
Mixed lymphocyte reaction

ASJC Scopus subject areas

Molecular Medicine
Pharmacology

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Effect of antibodies against intercellular adhesion molecule-1, B7, and CD40 on interleukin-18-treated human mixed lymphocyte reaction. / Takahashi, Hideo Kohka; Iwagaki, Hiromi; Tamura, Ryuji; Yagi, Takahito ; Yoshino, Tadashi; Mori, Shuji; Tanaka, Noriaki; Nishibori, Masahiro.

In: Journal of Pharmacological Sciences, Vol. 97, No. 3, 03.2005, p. 447-450.

Research output: Contribution to journal › Article › peer-review

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abstract = "The interleukin (IL)-18 level in plasma is elevated during the acute rejection after organ transplantation. IL-18 elicits adhesion molecule expression as well as interferon-γ/IL-12 production and T-cell proliferation in the human mixed lymphocyte reaction, an in vitro model of acute rejection. We examined whether antibodies (Abs) against intercellular adhesion molecule (ICAM)-1, B7, CD40, and CD40, ligand (CD40L) affect the cytokine production and T-cell proliferation. Anti-ICAM-1 and BV Abs suppressed the cytokine production, while all Abs inhibited T-cell proliferation. ICAM-1 and B7 as well as CD40 may play different roles in the acute rejection.",

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AU - Takahashi, Hideo Kohka

AU - Iwagaki, Hiromi

AU - Tamura, Ryuji

AU - Yagi, Takahito

AU - Yoshino, Tadashi

AU - Mori, Shuji

AU - Tanaka, Noriaki

AU - Nishibori, Masahiro

PY - 2005/3

Y1 - 2005/3

N2 - The interleukin (IL)-18 level in plasma is elevated during the acute rejection after organ transplantation. IL-18 elicits adhesion molecule expression as well as interferon-γ/IL-12 production and T-cell proliferation in the human mixed lymphocyte reaction, an in vitro model of acute rejection. We examined whether antibodies (Abs) against intercellular adhesion molecule (ICAM)-1, B7, CD40, and CD40, ligand (CD40L) affect the cytokine production and T-cell proliferation. Anti-ICAM-1 and BV Abs suppressed the cytokine production, while all Abs inhibited T-cell proliferation. ICAM-1 and B7 as well as CD40 may play different roles in the acute rejection.

AB - The interleukin (IL)-18 level in plasma is elevated during the acute rejection after organ transplantation. IL-18 elicits adhesion molecule expression as well as interferon-γ/IL-12 production and T-cell proliferation in the human mixed lymphocyte reaction, an in vitro model of acute rejection. We examined whether antibodies (Abs) against intercellular adhesion molecule (ICAM)-1, B7, CD40, and CD40, ligand (CD40L) affect the cytokine production and T-cell proliferation. Anti-ICAM-1 and BV Abs suppressed the cytokine production, while all Abs inhibited T-cell proliferation. ICAM-1 and B7 as well as CD40 may play different roles in the acute rejection.

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KW - Interleukin-18

KW - Mixed lymphocyte reaction

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Effect of antibodies against intercellular adhesion molecule-1, B7, and CD40 on interleukin-18-treated human mixed lymphocyte reaction

Abstract

Keywords

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