Effect of antibodies against intercellular adhesion molecule-1, B7, and CD40 on interleukin-18-treated human mixed lymphocyte reaction

Hideo Kohka Takahashi, Hiromi Iwagaki, Ryuji Tamura, Takahito Yagi, Tadashi Yoshino, Shuji Mori, Noriaki Tanaka, Masahiro Nishibori

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The interleukin (IL)-18 level in plasma is elevated during the acute rejection after organ transplantation. IL-18 elicits adhesion molecule expression as well as interferon-γ/IL-12 production and T-cell proliferation in the human mixed lymphocyte reaction, an in vitro model of acute rejection. We examined whether antibodies (Abs) against intercellular adhesion molecule (ICAM)-1, B7, CD40, and CD40, ligand (CD40L) affect the cytokine production and T-cell proliferation. Anti-ICAM-1 and BV Abs suppressed the cytokine production, while all Abs inhibited T-cell proliferation. ICAM-1 and B7 as well as CD40 may play different roles in the acute rejection.

Original languageEnglish
Pages (from-to)447-450
Number of pages4
JournalJournal of Pharmacological Sciences
Volume97
Issue number3
DOIs
Publication statusPublished - Mar 2005

Keywords

  • Adhesion molecule
  • Interleukin-18
  • Mixed lymphocyte reaction

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Fingerprint Dive into the research topics of 'Effect of antibodies against intercellular adhesion molecule-1, B7, and CD40 on interleukin-18-treated human mixed lymphocyte reaction'. Together they form a unique fingerprint.

  • Cite this