Abstract
The interleukin (IL)-18 level in plasma is elevated during the acute rejection after organ transplantation. IL-18 elicits adhesion molecule expression as well as interferon-γ/IL-12 production and T-cell proliferation in the human mixed lymphocyte reaction, an in vitro model of acute rejection. We examined whether antibodies (Abs) against intercellular adhesion molecule (ICAM)-1, B7, CD40, and CD40, ligand (CD40L) affect the cytokine production and T-cell proliferation. Anti-ICAM-1 and BV Abs suppressed the cytokine production, while all Abs inhibited T-cell proliferation. ICAM-1 and B7 as well as CD40 may play different roles in the acute rejection.
| Original language | English |
|---|---|
| Pages (from-to) | 447-450 |
| Number of pages | 4 |
| Journal | Journal of Pharmacological Sciences |
| Volume | 97 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 2005 |
Keywords
- Adhesion molecule
- Interleukin-18
- Mixed lymphocyte reaction
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology
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Takahashi, H. K., Iwagaki, H., Tamura, R., Yagi, T., Yoshino, T., Mori, S., Tanaka, N., & Nishibori, M. (2005). Effect of antibodies against intercellular adhesion molecule-1, B7, and CD40 on interleukin-18-treated human mixed lymphocyte reaction. Journal of Pharmacological Sciences, 97(3), 447-450. https://doi.org/10.1254/jphs.SC0040167