Abstract
The interleukin (IL)-18 level in plasma is elevated during the acute rejection after organ transplantation. IL-18 elicits adhesion molecule expression as well as interferon-γ/IL-12 production and T-cell proliferation in the human mixed lymphocyte reaction, an in vitro model of acute rejection. We examined whether antibodies (Abs) against intercellular adhesion molecule (ICAM)-1, B7, CD40, and CD40, ligand (CD40L) affect the cytokine production and T-cell proliferation. Anti-ICAM-1 and BV Abs suppressed the cytokine production, while all Abs inhibited T-cell proliferation. ICAM-1 and B7 as well as CD40 may play different roles in the acute rejection.
| Original language | English |
|---|---|
| Pages (from-to) | 447-450 |
| Number of pages | 4 |
| Journal | Journal of Pharmacological Sciences |
| Volume | 97 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 2005 |
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Keywords
- Adhesion molecule
- Interleukin-18
- Mixed lymphocyte reaction
ASJC Scopus subject areas
- Pharmacology
Cite this
Effect of antibodies against intercellular adhesion molecule-1, B7, and CD40 on interleukin-18-treated human mixed lymphocyte reaction. / Takahashi, Hideo Kohka; Iwagaki, Hiromi; Tamura, Ryuji; Yagi, Takahito; Yoshino, Tadashi; Mori, Shuji; Tanaka, Noriaki; Nishibori, Masahiro.
In: Journal of Pharmacological Sciences, Vol. 97, No. 3, 03.2005, p. 447-450.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of antibodies against intercellular adhesion molecule-1, B7, and CD40 on interleukin-18-treated human mixed lymphocyte reaction
AU - Takahashi, Hideo Kohka
AU - Iwagaki, Hiromi
AU - Tamura, Ryuji
AU - Yagi, Takahito
AU - Yoshino, Tadashi
AU - Mori, Shuji
AU - Tanaka, Noriaki
AU - Nishibori, Masahiro
PY - 2005/3
Y1 - 2005/3
N2 - The interleukin (IL)-18 level in plasma is elevated during the acute rejection after organ transplantation. IL-18 elicits adhesion molecule expression as well as interferon-γ/IL-12 production and T-cell proliferation in the human mixed lymphocyte reaction, an in vitro model of acute rejection. We examined whether antibodies (Abs) against intercellular adhesion molecule (ICAM)-1, B7, CD40, and CD40, ligand (CD40L) affect the cytokine production and T-cell proliferation. Anti-ICAM-1 and BV Abs suppressed the cytokine production, while all Abs inhibited T-cell proliferation. ICAM-1 and B7 as well as CD40 may play different roles in the acute rejection.
AB - The interleukin (IL)-18 level in plasma is elevated during the acute rejection after organ transplantation. IL-18 elicits adhesion molecule expression as well as interferon-γ/IL-12 production and T-cell proliferation in the human mixed lymphocyte reaction, an in vitro model of acute rejection. We examined whether antibodies (Abs) against intercellular adhesion molecule (ICAM)-1, B7, CD40, and CD40, ligand (CD40L) affect the cytokine production and T-cell proliferation. Anti-ICAM-1 and BV Abs suppressed the cytokine production, while all Abs inhibited T-cell proliferation. ICAM-1 and B7 as well as CD40 may play different roles in the acute rejection.
KW - Adhesion molecule
KW - Interleukin-18
KW - Mixed lymphocyte reaction
UR - http://www.scopus.com/inward/record.url?scp=17144395203&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=17144395203&partnerID=8YFLogxK
U2 - 10.1254/jphs.SC0040167
DO - 10.1254/jphs.SC0040167
M3 - Article
C2 - 15764836
AN - SCOPUS:17144395203
VL - 97
SP - 447
EP - 450
JO - Journal of Pharmacological Sciences
JF - Journal of Pharmacological Sciences
SN - 1347-8648
IS - 3
ER -