Abstract
Impairment of insulin-dependent glucose uptake in skeletal muscles plays a major role in the pathogenesis of diabetes mellitus. Angiotensin converting-enzyme inhibitor (ACEI) has been demonstrated to improve insulin-sensitivity in diabetic patients, partly through the increase in peripheral blood flow mediated by either suppressed angiotensin II or elevated bradykinin. Recently, angiotensin II type-1 receptor blocker (ARB) has been shown to produce similar effects, postulating the importance of intracellular signaling cross-talk between angiotensin II and insulin. In this brief review, we focused on insulin receptor substrate-1(IRS-1) in skeletal muscle cells, and the significance of its serine(612)-phosphorylation was discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 1945-1948 |
| Number of pages | 4 |
| Journal | Nippon rinsho. Japanese journal of clinical medicine |
| Volume | 60 |
| Issue number | 10 |
| Publication status | Published - Jan 1 2002 |
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Effect of angiotensin II receptor blocker on insulin signaling in skeletal muscle cells. / Kaihara, Masanobu; Nakamura, Yoshio; Makino, Hirofumi.
In: Nippon rinsho. Japanese journal of clinical medicine, Vol. 60, No. 10, 01.01.2002, p. 1945-1948.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Effect of angiotensin II receptor blocker on insulin signaling in skeletal muscle cells
AU - Kaihara, Masanobu
AU - Nakamura, Yoshio
AU - Makino, Hirofumi
PY - 2002/1/1
Y1 - 2002/1/1
N2 - Impairment of insulin-dependent glucose uptake in skeletal muscles plays a major role in the pathogenesis of diabetes mellitus. Angiotensin converting-enzyme inhibitor (ACEI) has been demonstrated to improve insulin-sensitivity in diabetic patients, partly through the increase in peripheral blood flow mediated by either suppressed angiotensin II or elevated bradykinin. Recently, angiotensin II type-1 receptor blocker (ARB) has been shown to produce similar effects, postulating the importance of intracellular signaling cross-talk between angiotensin II and insulin. In this brief review, we focused on insulin receptor substrate-1(IRS-1) in skeletal muscle cells, and the significance of its serine(612)-phosphorylation was discussed.
AB - Impairment of insulin-dependent glucose uptake in skeletal muscles plays a major role in the pathogenesis of diabetes mellitus. Angiotensin converting-enzyme inhibitor (ACEI) has been demonstrated to improve insulin-sensitivity in diabetic patients, partly through the increase in peripheral blood flow mediated by either suppressed angiotensin II or elevated bradykinin. Recently, angiotensin II type-1 receptor blocker (ARB) has been shown to produce similar effects, postulating the importance of intracellular signaling cross-talk between angiotensin II and insulin. In this brief review, we focused on insulin receptor substrate-1(IRS-1) in skeletal muscle cells, and the significance of its serine(612)-phosphorylation was discussed.
UR - http://www.scopus.com/inward/record.url?scp=0036776986&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036776986&partnerID=8YFLogxK
M3 - Review article
C2 - 12397689
AN - SCOPUS:0036776986
VL - 60
SP - 1945
EP - 1948
JO - Nippon rinsho. Japanese journal of clinical medicine
JF - Nippon rinsho. Japanese journal of clinical medicine
SN - 0047-1852
IS - 10
ER -