Abstract
Impairment of insulin-dependent glucose uptake in skeletal muscles plays a major role in the pathogenesis of diabetes mellitus. Angiotensin converting-enzyme inhibitor (ACEI) has been demonstrated to improve insulin-sensitivity in diabetic patients, partly through the increase in peripheral blood flow mediated by either suppressed angiotensin II or elevated bradykinin. Recently, angiotensin II type-1 receptor blocker (ARB) has been shown to produce similar effects, postulating the importance of intracellular signaling cross-talk between angiotensin II and insulin. In this brief review, we focused on insulin receptor substrate-1(IRS-1) in skeletal muscle cells, and the significance of its serine(612)-phosphorylation was discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 1945-1948 |
| Number of pages | 4 |
| Journal | Nippon rinsho. Japanese journal of clinical medicine |
| Volume | 60 |
| Issue number | 10 |
| Publication status | Published - Oct 2002 |
ASJC Scopus subject areas
- Medicine(all)
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Kaihara, M., Nakamura, Y., & Makino, H. (2002). Effect of angiotensin II receptor blocker on insulin signaling in skeletal muscle cells. Nippon rinsho. Japanese journal of clinical medicine, 60(10), 1945-1948.