Effect of amodiaquine, a histamine N-methyltransferase inhibitor, on, Propionibacterium acnes and lipopolysaccharide-induced hepatitis in mice

Akira Yokoyama, Shuji Mori, Hideo K. Takahashi, Toru Kanke, Hidenori Wake, Masahiro Nishibori

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We examined whether treatment with amodiaquine, a potent inhibitor of histamine N-methyltransferase protects mice from Propionibacterium acnes (P. acnes)-primed and lipopolysaccharide (LPS)-induced hepatitis. The subcutaneous injection of amodiaquine (2 and 5 mg/kg) significantly increased the histamine levels in the liver in comparison to saline treated mice. Pretreatment with amodiaquine also improved the survival rate of the hepatitis mice, and this improvement was partially associated with the decrease in serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Amodiaquine partially suppressed increases of tumor necrosis factor (TNF)-α in the serum and TNF-α mRNA expression in the liver, whereas the expression of interleukin (IL)-18, interferon (IFN)-γ and IL-12 in the liver was not changed by amodiaquine treatment. In conclusion, the present findings suggested that the elevation of endogenous histamine by amodiaquine may thus play a protective role through the regulation of TNF-α production in endotoxin-induced hepatic injury mice.

Original languageEnglish
Pages (from-to)179-184
Number of pages6
JournalEuropean Journal of Pharmacology
Volume558
Issue number1-3
DOIs
Publication statusPublished - Mar 8 2007

Keywords

  • Amodiaquine
  • Hepatitis
  • Lipopolysaccharide
  • Propionibacterium acnes

ASJC Scopus subject areas

  • Pharmacology

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