Effect of a low dose of midazolam on high blood pressure in dental patients: A randomised, double-blind, placebo-controlled, two-centre study

Yoshihisa Watanabe, Hitoshi Higuchi, Minako Ishii-Maruhama, Yuka Honda, Akiko Yabuki-Kawase, Ayaka Yamane-Hirano, Yumiko Tomoyasu, Shigeru Maeda, Takuya Miyawaki

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Some patients have transient hypertension before dental treatment as a result of anxiety and stress. Midazolam is an anxiolytic, and thought to be effective for the management of this sort of transient hypertension. We have evaluated in a randomised, controlled trial whether a low dose of midazolam can lower blood pressure in dental patients to an acceptable level without excessive sedation. Suitable patients were randomised to be given midazolam (trial group) or physiological saline (control group) intravenously. Blood pressure, heart rate, degree of anxiety, and amount of sedation were measured before and after injection. After injection, blood pressure in the trial group significantly decreased to clinically acceptable levels compared with controls. The degree of anxiety in the trial group was also significantly less than that in the control group, but there were no significant differences in sedation. These results suggest that injection of a low dose of midazolam stabilises the blood pressure of dental patients with transient hypertension.

Original languageEnglish
Pages (from-to)443-448
Number of pages6
JournalBritish Journal of Oral and Maxillofacial Surgery
Volume54
Issue number4
DOIs
Publication statusPublished - May 1 2016

Keywords

  • Anxiety
  • Hypertension
  • Midazolam
  • Sedation

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology

Fingerprint

Dive into the research topics of 'Effect of a low dose of midazolam on high blood pressure in dental patients: A randomised, double-blind, placebo-controlled, two-centre study'. Together they form a unique fingerprint.

Cite this