Effect of 2-guanidinoethanol on levels of monoamines and their metabolites in the rat brain

Isao Yokoi, Takehiko Ito, Katsumi Yufu, Kenji Akiyama, Michiyoshi Satoh, Shinji Murakami, Hideaki Kabuto, Akitane Mori

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The contents of monoamines and their metabolites in rat brains 3 hours after the intracerebroventricular injection of 6 μmol of 2-guanidino-ethanol (GEt) were measured by HPLC. GEt which is a configurational analogue of 4-aminobutanoic acid (GABA) induced severe running fits and tonic-clonic convulsions as well as epileptic discharges. In GEt-administered rats, dopamine (DA) decreased in the cortex, hippocampus and hypothalamus. 3,4-Dihydroxyphenylacetic acid (DOPAC) increased to about the same level in all brain regions, therefore the distribution of DOPAC appeared to be homogeneous in the brain. The homovanillic acid levels also increased in the striatum and hippocampus. No significant change in the norepinephrine contents was observed in any region. The turnover ratio of DA increased significantly except in the striatum. Serotonin levels increased in the hypothalamus and midbrain by GEt administration, though 5-hydroxyindoleacetic acid levels showed no change in any of the brain regions. These data suggest that the activity of dopaminergic and serotonergic neurons are increased by GEt.

Original languageEnglish
Pages (from-to)1155-1159
Number of pages5
JournalNeurochemical Research
Volume16
Issue number10
DOIs
Publication statusPublished - Oct 1991

Fingerprint

Metabolites
Rats
Brain
Ethanol
3,4-Dihydroxyphenylacetic Acid
gamma-Aminobutyric Acid
Hypothalamus
Hippocampus
Dopamine
Tonic-Clonic Epilepsy
Serotonergic Neurons
Homovanillic Acid
Hydroxyindoleacetic Acid
Dopaminergic Neurons
Mesencephalon
Running
Neurons
Serotonin
Norepinephrine
High Pressure Liquid Chromatography

Keywords

  • 2′-guanidinoethanol
  • catecholamine
  • GABA antagonist
  • monoamine metabolisms

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry

Cite this

Effect of 2-guanidinoethanol on levels of monoamines and their metabolites in the rat brain. / Yokoi, Isao; Ito, Takehiko; Yufu, Katsumi; Akiyama, Kenji; Satoh, Michiyoshi; Murakami, Shinji; Kabuto, Hideaki; Mori, Akitane.

In: Neurochemical Research, Vol. 16, No. 10, 10.1991, p. 1155-1159.

Research output: Contribution to journalArticle

Yokoi, I, Ito, T, Yufu, K, Akiyama, K, Satoh, M, Murakami, S, Kabuto, H & Mori, A 1991, 'Effect of 2-guanidinoethanol on levels of monoamines and their metabolites in the rat brain', Neurochemical Research, vol. 16, no. 10, pp. 1155-1159. https://doi.org/10.1007/BF00966595
Yokoi, Isao ; Ito, Takehiko ; Yufu, Katsumi ; Akiyama, Kenji ; Satoh, Michiyoshi ; Murakami, Shinji ; Kabuto, Hideaki ; Mori, Akitane. / Effect of 2-guanidinoethanol on levels of monoamines and their metabolites in the rat brain. In: Neurochemical Research. 1991 ; Vol. 16, No. 10. pp. 1155-1159.
@article{92bd40e9671445308bb33adcc53cd0b9,
title = "Effect of 2-guanidinoethanol on levels of monoamines and their metabolites in the rat brain",
abstract = "The contents of monoamines and their metabolites in rat brains 3 hours after the intracerebroventricular injection of 6 μmol of 2-guanidino-ethanol (GEt) were measured by HPLC. GEt which is a configurational analogue of 4-aminobutanoic acid (GABA) induced severe running fits and tonic-clonic convulsions as well as epileptic discharges. In GEt-administered rats, dopamine (DA) decreased in the cortex, hippocampus and hypothalamus. 3,4-Dihydroxyphenylacetic acid (DOPAC) increased to about the same level in all brain regions, therefore the distribution of DOPAC appeared to be homogeneous in the brain. The homovanillic acid levels also increased in the striatum and hippocampus. No significant change in the norepinephrine contents was observed in any region. The turnover ratio of DA increased significantly except in the striatum. Serotonin levels increased in the hypothalamus and midbrain by GEt administration, though 5-hydroxyindoleacetic acid levels showed no change in any of the brain regions. These data suggest that the activity of dopaminergic and serotonergic neurons are increased by GEt.",
keywords = "2′-guanidinoethanol, catecholamine, GABA antagonist, monoamine metabolisms",
author = "Isao Yokoi and Takehiko Ito and Katsumi Yufu and Kenji Akiyama and Michiyoshi Satoh and Shinji Murakami and Hideaki Kabuto and Akitane Mori",
year = "1991",
month = "10",
doi = "10.1007/BF00966595",
language = "English",
volume = "16",
pages = "1155--1159",
journal = "Neurochemical Research",
issn = "0364-3190",
publisher = "Springer New York",
number = "10",

}

TY - JOUR

T1 - Effect of 2-guanidinoethanol on levels of monoamines and their metabolites in the rat brain

AU - Yokoi, Isao

AU - Ito, Takehiko

AU - Yufu, Katsumi

AU - Akiyama, Kenji

AU - Satoh, Michiyoshi

AU - Murakami, Shinji

AU - Kabuto, Hideaki

AU - Mori, Akitane

PY - 1991/10

Y1 - 1991/10

N2 - The contents of monoamines and their metabolites in rat brains 3 hours after the intracerebroventricular injection of 6 μmol of 2-guanidino-ethanol (GEt) were measured by HPLC. GEt which is a configurational analogue of 4-aminobutanoic acid (GABA) induced severe running fits and tonic-clonic convulsions as well as epileptic discharges. In GEt-administered rats, dopamine (DA) decreased in the cortex, hippocampus and hypothalamus. 3,4-Dihydroxyphenylacetic acid (DOPAC) increased to about the same level in all brain regions, therefore the distribution of DOPAC appeared to be homogeneous in the brain. The homovanillic acid levels also increased in the striatum and hippocampus. No significant change in the norepinephrine contents was observed in any region. The turnover ratio of DA increased significantly except in the striatum. Serotonin levels increased in the hypothalamus and midbrain by GEt administration, though 5-hydroxyindoleacetic acid levels showed no change in any of the brain regions. These data suggest that the activity of dopaminergic and serotonergic neurons are increased by GEt.

AB - The contents of monoamines and their metabolites in rat brains 3 hours after the intracerebroventricular injection of 6 μmol of 2-guanidino-ethanol (GEt) were measured by HPLC. GEt which is a configurational analogue of 4-aminobutanoic acid (GABA) induced severe running fits and tonic-clonic convulsions as well as epileptic discharges. In GEt-administered rats, dopamine (DA) decreased in the cortex, hippocampus and hypothalamus. 3,4-Dihydroxyphenylacetic acid (DOPAC) increased to about the same level in all brain regions, therefore the distribution of DOPAC appeared to be homogeneous in the brain. The homovanillic acid levels also increased in the striatum and hippocampus. No significant change in the norepinephrine contents was observed in any region. The turnover ratio of DA increased significantly except in the striatum. Serotonin levels increased in the hypothalamus and midbrain by GEt administration, though 5-hydroxyindoleacetic acid levels showed no change in any of the brain regions. These data suggest that the activity of dopaminergic and serotonergic neurons are increased by GEt.

KW - 2′-guanidinoethanol

KW - catecholamine

KW - GABA antagonist

KW - monoamine metabolisms

UR - http://www.scopus.com/inward/record.url?scp=0026052377&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026052377&partnerID=8YFLogxK

U2 - 10.1007/BF00966595

DO - 10.1007/BF00966595

M3 - Article

VL - 16

SP - 1155

EP - 1159

JO - Neurochemical Research

JF - Neurochemical Research

SN - 0364-3190

IS - 10

ER -