Effect and tolerability of blonanserin in severe delusion with various types of dementia

Manabu Takaki; Hajime Honda; Seishi Terada; Yosuke Uchitomi

doi:10.1111/psyg.12090

Effect and tolerability of blonanserin in severe delusion with various types of dementia

Manabu Takaki, Hajime Honda, Seishi Terada, Yosuke Uchitomi

University Hospital

Research output: Contribution to journal › Article › peer-review

Abstract

Low-dose blonanserin was effective for treating severe delusions in six patients with various types of dementia, and it was also well tolerated. Delusion and hallucination scores, as measured by the Neuropsychiatric Inventory, improved, and extrapyramidal symptom scores, as measured by the Drug-Induced Extrapyramidal Symptoms Scale, were unchanged. Blonanserin has strong dopamine D₂ receptor-, 5-hydroxytryptamine 2A receptor-, and dopamine D₃ receptor-blocking activities and weak 5-hydroxytryptamine-2C, α₁-, histamine H₁-, and muscarinic M₁-blocking activities. Its unique characteristics may make it suitable for treating severe delusions and hallucination in patients with dementia. Psychogeriatrics

Original language	English
Pages (from-to)	144-146
Number of pages	3
Journal	Psychogeriatrics
Volume	15
Issue number	2
DOIs	https://doi.org/10.1111/psyg.12090
Publication status	Published - Jun 1 2015

Keywords

Blonanserin
D<inf>3</inf> receptor
Delusion
Dementia
Hallucination

ASJC Scopus subject areas

Gerontology
Geriatrics and Gerontology
Psychiatry and Mental health

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PY - 2015/6/1

Y1 - 2015/6/1

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Effect and tolerability of blonanserin in severe delusion with various types of dementia

Abstract

Keywords

ASJC Scopus subject areas

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