Abstract
Intestinal colonization by bacteria of oral origin has been correlated with several negative health outcomes, including inflammatory bowel disease. However, a causal role of oral bacteria ectopically colonizing the intestine remains unclear. Using gnotobiotic techniques, we show that strains of Klebsiella spp. isolated from the salivary microbiota are strong inducers of T helper 1 (TH1) cells when they colonize in the gut. These Klebsiella strains are resistant to multiple antibiotics, tend to colonize when the intestinal microbiota is dysbiotic, and elicit a severe gut inflammation in the context of a genetically susceptible host. Our findings suggest that the oral cavity may serve as a reservoir for potential intestinal pathobionts that can exacerbate intestinal disease.
Original language | English |
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Pages (from-to) | 359-365 |
Number of pages | 7 |
Journal | Science |
Volume | 358 |
Issue number | 6361 |
DOIs | |
Publication status | Published - Oct 20 2017 |
Externally published | Yes |
Keywords
- Animals
- Anti-Bacterial Agents/pharmacology
- Drug Resistance, Bacterial
- Dysbiosis/immunology
- Germ-Free Life
- Inflammatory Bowel Diseases/immunology
- Intestines/immunology
- Klebsiella/drug effects
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Microbiota/immunology
- Mouth/microbiology
- Saliva/microbiology
- Th1 Cells/immunology