Early treatment with cyclosporin a ameliorates the reduction of muscarinic acetylcholine receptors in gerbil hippocampus after transient forebrain ischemia

Yoichi Kondo, Masato Asanuma, Emi Iwata, Fumio Kondo, Ikuko Miyazaki, Norio Ogawa

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Recent evidence has suggested that cyclosporin A (CsA), an immunosuppressive agent, has neuroprotective properties. However, its mechanisms associated with this activity remain unclear. We have previously shown that post-ischemic administration of CsA daily for 14 days prevented the decrease of muscarinic acetylcholine receptor binding in the hippocampus in the gerbil model of 5-min transient forebrain ischemia. In the present study, CsA (5 mg/kg, subcutaneously) was administered to each animal just after, 2 and 6 h after ischemia so as not to exert its immunosuppressive effect. Initial CsA treatment significantly restored the declined muscarinic acetylcholine receptor binding of the hippocampus 14 days after ischemia similar to the previous report. However, CsA did not alter reactive changes of astrocytes and microgila in the CA1 area of the hippocampus, which had been suppressed by daily administration. These results indicate that CsA could positively modulate the hippocampal acetylcholine neurotransmission system broken down through the ischemia-induced pyramidal cell death and its action mechanism may have no relation to the immunosuppressive properties.

Original languageEnglish
Pages (from-to)9-13
Number of pages5
JournalNeurochemical Research
Volume24
Issue number1
DOIs
Publication statusPublished - Feb 13 1999

Keywords

  • Acetylcholine receptor
  • Cyclosporin A
  • Gerbil
  • Hippocampus
  • Ischemia

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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