Early temporal changes in coronary flow velocity patterns in patients with acute myocardial infarction demonstrating the 'no-reflow' phenomenon

Katsuomi Iwakura, Hiroshi Itoh, Nagahiro Nishikawa, Kazuya Hiraoka, Ken Sugimoto, Yorihiko Higashino, Tohru Masuyama, Masatsugu Hori, Kenshi Fujii, Takazo Minamino

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Abstract

Coronary flow velocity pattern in patients with acute myocardial infarction demonstrating no-reflow phenomenon is characterized with early systolic retrograde flow and rapid deceleration of diastolic flow velocity. In this study, we investigated the early temporal changes in microvascular function in patients with the no-reflow phenomenon. Among 144 patients with a first acute myocardial infarction, 33 exhibited sizable no-reflow phenomenon after coronary reperfusion with myocardial contrast echocardiography. We assessed temporal changes in coronary flow velocity patterns with the Doppler guidewire. The early systolic retrograde flow was observed ≤10 seconds after reperfusion in 16 patients (group A) or later in 17 patients (331 ± 327 seconds, group B). Diastolic deceleration rate was higher in group A than in group B at 1 minute after reperfusion. It gradually increased in group B and showed comparable value to group A 10 minutes later. Group A had longer elapsed time from symptom onset to reperfusion and a greater number of infarct Q waves before reperfusion than group B (14 ± 13 vs 5 ± 2 hours, p

Original languageEnglish
Pages (from-to)415-419
Number of pages5
JournalAmerican Journal of Cardiology
Volume84
Issue number4
DOIs
Publication statusPublished - Aug 15 1999
Externally publishedYes

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No-Reflow Phenomenon
Myocardial Infarction
Reperfusion
Deceleration
Myocardial Reperfusion
antineoplaston A10
Echocardiography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Early temporal changes in coronary flow velocity patterns in patients with acute myocardial infarction demonstrating the 'no-reflow' phenomenon. / Iwakura, Katsuomi; Itoh, Hiroshi; Nishikawa, Nagahiro; Hiraoka, Kazuya; Sugimoto, Ken; Higashino, Yorihiko; Masuyama, Tohru; Hori, Masatsugu; Fujii, Kenshi; Minamino, Takazo.

In: American Journal of Cardiology, Vol. 84, No. 4, 15.08.1999, p. 415-419.

Research output: Contribution to journalArticle

Iwakura, Katsuomi ; Itoh, Hiroshi ; Nishikawa, Nagahiro ; Hiraoka, Kazuya ; Sugimoto, Ken ; Higashino, Yorihiko ; Masuyama, Tohru ; Hori, Masatsugu ; Fujii, Kenshi ; Minamino, Takazo. / Early temporal changes in coronary flow velocity patterns in patients with acute myocardial infarction demonstrating the 'no-reflow' phenomenon. In: American Journal of Cardiology. 1999 ; Vol. 84, No. 4. pp. 415-419.
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AU - Sugimoto, Ken

AU - Higashino, Yorihiko

AU - Masuyama, Tohru

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