Early Emergence of Neuropsychiatric Symptoms in Cognitively Normal Subjects and Mild Cognitive Impairment

Keiichiro Tsunoda, Toru Yamashita, Yosuke Osakada, Ryo Sasaki, Koh Tadokoro, Namiko Matsumoto, Emi Nomura, Ryuta Morihara, Yumiko Nakano, Yoshiaki Takahashi, Noriko Hatanaka, Jingwei Shang, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe

Research output: Contribution to journalArticle

Abstract

The world is rapidly aging and facing an increase in the number of dementia patients, so it is important to detect the preclinical stage of dementia in such countries. We examined both cognitive and affective functions among cognitively normal control (n=218), mild cognitive impairment (MCI, n=146), and Alzheimer's disease (AD, n=305) subjects using two evaluation tools for behavioral and psychological symptoms of dementia (BPSD) [Abe's BPSD score (ABS) and mild behavioral impairment (MBI)]. BPSD were present in 12.4% (ABS) and 9.6% (MBI) of cognitively normal people, 34.9% and 32.2% in MCI subjects, and 66.2% and 51.1% in AD patients. Both ABS (§p<0.05) and MBI (§§p<0.01) score showed worse score with cognitive decline of the Mini-Mental State Examination in the AD group in BPSD-positive participants. Similar correlations were found in all participants in AD group (||||p<0.01 versus ABS and MBI). Among the subscales in BPSD-positive participants, an apathy/indifference score of ABS and a decreased motivation of MBI showed significant differences in AD patients compared to the control and MCI subjects (∗∗p<0.01). In addition, subscale analyses further showed a downward trend from the control to MCI and AD subjects in four ABS subscales and three MBI subscales. The present study showed the preclinical presence of BPSD in cognitively normal people, more so in MCI subjects, and ABS detected BPSD more sensitively than MBI in all three groups.

Original languageEnglish
Pages (from-to)209-215
Number of pages7
JournalJournal of Alzheimer's Disease
Volume73
Issue number1
DOIs
Publication statusPublished - Jan 1 2020

Fingerprint

Behavioral Symptoms
Dementia
Psychology
Cognitive Dysfunction
Apathy
Cognition
Motivation
Alzheimer Disease

Keywords

  • Affective symptoms
  • behavioral symptoms
  • cognitive dysfunction
  • dementia

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Early Emergence of Neuropsychiatric Symptoms in Cognitively Normal Subjects and Mild Cognitive Impairment. / Tsunoda, Keiichiro; Yamashita, Toru; Osakada, Yosuke; Sasaki, Ryo; Tadokoro, Koh; Matsumoto, Namiko; Nomura, Emi; Morihara, Ryuta; Nakano, Yumiko; Takahashi, Yoshiaki; Hatanaka, Noriko; Shang, Jingwei; Sato, Kota; Takemoto, Mami; Hishikawa, Nozomi; Ohta, Yasuyuki; Abe, Koji.

In: Journal of Alzheimer's Disease, Vol. 73, No. 1, 01.01.2020, p. 209-215.

Research output: Contribution to journalArticle

Tsunoda, K, Yamashita, T, Osakada, Y, Sasaki, R, Tadokoro, K, Matsumoto, N, Nomura, E, Morihara, R, Nakano, Y, Takahashi, Y, Hatanaka, N, Shang, J, Sato, K, Takemoto, M, Hishikawa, N, Ohta, Y & Abe, K 2020, 'Early Emergence of Neuropsychiatric Symptoms in Cognitively Normal Subjects and Mild Cognitive Impairment', Journal of Alzheimer's Disease, vol. 73, no. 1, pp. 209-215. https://doi.org/10.3233/JAD-190669
Tsunoda, Keiichiro ; Yamashita, Toru ; Osakada, Yosuke ; Sasaki, Ryo ; Tadokoro, Koh ; Matsumoto, Namiko ; Nomura, Emi ; Morihara, Ryuta ; Nakano, Yumiko ; Takahashi, Yoshiaki ; Hatanaka, Noriko ; Shang, Jingwei ; Sato, Kota ; Takemoto, Mami ; Hishikawa, Nozomi ; Ohta, Yasuyuki ; Abe, Koji. / Early Emergence of Neuropsychiatric Symptoms in Cognitively Normal Subjects and Mild Cognitive Impairment. In: Journal of Alzheimer's Disease. 2020 ; Vol. 73, No. 1. pp. 209-215.
@article{9b93c9e6f7aa4664a6b4205821439399,
title = "Early Emergence of Neuropsychiatric Symptoms in Cognitively Normal Subjects and Mild Cognitive Impairment",
abstract = "The world is rapidly aging and facing an increase in the number of dementia patients, so it is important to detect the preclinical stage of dementia in such countries. We examined both cognitive and affective functions among cognitively normal control (n=218), mild cognitive impairment (MCI, n=146), and Alzheimer's disease (AD, n=305) subjects using two evaluation tools for behavioral and psychological symptoms of dementia (BPSD) [Abe's BPSD score (ABS) and mild behavioral impairment (MBI)]. BPSD were present in 12.4{\%} (ABS) and 9.6{\%} (MBI) of cognitively normal people, 34.9{\%} and 32.2{\%} in MCI subjects, and 66.2{\%} and 51.1{\%} in AD patients. Both ABS (§p<0.05) and MBI (§§p<0.01) score showed worse score with cognitive decline of the Mini-Mental State Examination in the AD group in BPSD-positive participants. Similar correlations were found in all participants in AD group (||||p<0.01 versus ABS and MBI). Among the subscales in BPSD-positive participants, an apathy/indifference score of ABS and a decreased motivation of MBI showed significant differences in AD patients compared to the control and MCI subjects (∗∗p<0.01). In addition, subscale analyses further showed a downward trend from the control to MCI and AD subjects in four ABS subscales and three MBI subscales. The present study showed the preclinical presence of BPSD in cognitively normal people, more so in MCI subjects, and ABS detected BPSD more sensitively than MBI in all three groups.",
keywords = "Affective symptoms, behavioral symptoms, cognitive dysfunction, dementia",
author = "Keiichiro Tsunoda and Toru Yamashita and Yosuke Osakada and Ryo Sasaki and Koh Tadokoro and Namiko Matsumoto and Emi Nomura and Ryuta Morihara and Yumiko Nakano and Yoshiaki Takahashi and Noriko Hatanaka and Jingwei Shang and Kota Sato and Mami Takemoto and Nozomi Hishikawa and Yasuyuki Ohta and Koji Abe",
year = "2020",
month = "1",
day = "1",
doi = "10.3233/JAD-190669",
language = "English",
volume = "73",
pages = "209--215",
journal = "Journal of Alzheimer's Disease",
issn = "1387-2877",
publisher = "IOS Press",
number = "1",

}

TY - JOUR

T1 - Early Emergence of Neuropsychiatric Symptoms in Cognitively Normal Subjects and Mild Cognitive Impairment

AU - Tsunoda, Keiichiro

AU - Yamashita, Toru

AU - Osakada, Yosuke

AU - Sasaki, Ryo

AU - Tadokoro, Koh

AU - Matsumoto, Namiko

AU - Nomura, Emi

AU - Morihara, Ryuta

AU - Nakano, Yumiko

AU - Takahashi, Yoshiaki

AU - Hatanaka, Noriko

AU - Shang, Jingwei

AU - Sato, Kota

AU - Takemoto, Mami

AU - Hishikawa, Nozomi

AU - Ohta, Yasuyuki

AU - Abe, Koji

PY - 2020/1/1

Y1 - 2020/1/1

N2 - The world is rapidly aging and facing an increase in the number of dementia patients, so it is important to detect the preclinical stage of dementia in such countries. We examined both cognitive and affective functions among cognitively normal control (n=218), mild cognitive impairment (MCI, n=146), and Alzheimer's disease (AD, n=305) subjects using two evaluation tools for behavioral and psychological symptoms of dementia (BPSD) [Abe's BPSD score (ABS) and mild behavioral impairment (MBI)]. BPSD were present in 12.4% (ABS) and 9.6% (MBI) of cognitively normal people, 34.9% and 32.2% in MCI subjects, and 66.2% and 51.1% in AD patients. Both ABS (§p<0.05) and MBI (§§p<0.01) score showed worse score with cognitive decline of the Mini-Mental State Examination in the AD group in BPSD-positive participants. Similar correlations were found in all participants in AD group (||||p<0.01 versus ABS and MBI). Among the subscales in BPSD-positive participants, an apathy/indifference score of ABS and a decreased motivation of MBI showed significant differences in AD patients compared to the control and MCI subjects (∗∗p<0.01). In addition, subscale analyses further showed a downward trend from the control to MCI and AD subjects in four ABS subscales and three MBI subscales. The present study showed the preclinical presence of BPSD in cognitively normal people, more so in MCI subjects, and ABS detected BPSD more sensitively than MBI in all three groups.

AB - The world is rapidly aging and facing an increase in the number of dementia patients, so it is important to detect the preclinical stage of dementia in such countries. We examined both cognitive and affective functions among cognitively normal control (n=218), mild cognitive impairment (MCI, n=146), and Alzheimer's disease (AD, n=305) subjects using two evaluation tools for behavioral and psychological symptoms of dementia (BPSD) [Abe's BPSD score (ABS) and mild behavioral impairment (MBI)]. BPSD were present in 12.4% (ABS) and 9.6% (MBI) of cognitively normal people, 34.9% and 32.2% in MCI subjects, and 66.2% and 51.1% in AD patients. Both ABS (§p<0.05) and MBI (§§p<0.01) score showed worse score with cognitive decline of the Mini-Mental State Examination in the AD group in BPSD-positive participants. Similar correlations were found in all participants in AD group (||||p<0.01 versus ABS and MBI). Among the subscales in BPSD-positive participants, an apathy/indifference score of ABS and a decreased motivation of MBI showed significant differences in AD patients compared to the control and MCI subjects (∗∗p<0.01). In addition, subscale analyses further showed a downward trend from the control to MCI and AD subjects in four ABS subscales and three MBI subscales. The present study showed the preclinical presence of BPSD in cognitively normal people, more so in MCI subjects, and ABS detected BPSD more sensitively than MBI in all three groups.

KW - Affective symptoms

KW - behavioral symptoms

KW - cognitive dysfunction

KW - dementia

UR - http://www.scopus.com/inward/record.url?scp=85077789279&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85077789279&partnerID=8YFLogxK

U2 - 10.3233/JAD-190669

DO - 10.3233/JAD-190669

M3 - Article

C2 - 31771056

AN - SCOPUS:85077789279

VL - 73

SP - 209

EP - 215

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

SN - 1387-2877

IS - 1

ER -