Early disturbance of a mitochondrial DNA expression in gerbil hippocampus after transient forebrain ischemia

Koji Abe, J. Kawagoe, K. Kogure

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The level of mRNA for cytochrome c oxidase subunit I (COX-I), which is encoded by mitochondrial DNA (mtDNA), progressively decreased in the hippocampal CA1 neurons of gerbils from 1-3 h of the reperfusion after 3.5 min of transient forebrain ischemia, and completely disappeared at 7 days. The activity of cytochrome c oxidase (COX) protein also showed the early decrease in the CA1 cells, and was followed by the reduction of the level of COX-I DNA after 2 days. However, the activity of succinic dehydrogenase (SDH), a mitochondrial enzyme that is encoded by nuclear DNA, maintained normal activity until 1 day in the CA1 cells, and significantly decreased at 7 days. These results suggest that the early onset and the progressive disturbance of a mitochondrial DNA expression found selectively in the CA1 neurons could cause progressive failure of energy production of the cells that eventually results in the neuronal cell death.

Original languageEnglish
Pages (from-to)173-176
Number of pages4
JournalNeuroscience Letters
Volume153
Issue number2
DOIs
Publication statusPublished - Apr 30 1993
Externally publishedYes

Fingerprint

Gerbillinae
Prosencephalon
Mitochondrial DNA
Hippocampus
Ischemia
Electron Transport Complex IV
Neurons
Succinate Dehydrogenase
DNA
Reperfusion
Oxidoreductases
Cell Death
Messenger RNA
Enzymes
Proteins

Keywords

  • Cytochrome c oxidase
  • Ischemia
  • Mitochondrial DNA

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Early disturbance of a mitochondrial DNA expression in gerbil hippocampus after transient forebrain ischemia. / Abe, Koji; Kawagoe, J.; Kogure, K.

In: Neuroscience Letters, Vol. 153, No. 2, 30.04.1993, p. 173-176.

Research output: Contribution to journalArticle

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