Early decrease of the immunophilin FKBP 52 in the spinal cord of a transgenic model for amyotrophic lateral sclerosis

Y. Manabe; H. Warita; T. Murakami; M. Shiote; T. Hayashi; N. Omori; I. Nagano; M. Shoji; K. Abe

doi:10.1016/S0006-8993(02)02466-6

Early decrease of the immunophilin FKBP 52 in the spinal cord of a transgenic model for amyotrophic lateral sclerosis

Y. Manabe, H. Warita, T. Murakami, M. Shiote, T. Hayashi, N. Omori, I. Nagano, M. Shoji, K. Abe

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Expressions of immunophilin FKBP-12 and FKBP-52 were examined in the spinal cord of transgenic mice with an ALS-linked mutant Cu/Zn superoxide dismutase (SOD1) gene. The immunoreactivity of FKBP-12 was present predominantly in the cytoplasm, but did not show a difference between age-matched wild type and transgenic (Tg) mice at 25 and 35 weeks. In contrast, the immunoreactivity of FKBP-52 was predominantly present in the nucleus, which progressively declined only in the Tg mice as early as an early presymptomatic stage at 25 weeks of age in the anterior horn neurons. The present result suggests that the downregulation of FKBP-52 may be involved in the pathogenesis in the early stages of amyotrophic lateral sclerosis (ALS).

Original language	English
Pages (from-to)	124-128
Number of pages	5
Journal	Brain Research
Volume	935
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(02)02466-6
Publication status	Published - May 10 2002

Keywords

ALS
FKBP-52
Immunophilin
SOD1
Transgenic mouse

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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@article{56a97b6d8fcb41bface92655e30e8370,

title = "Early decrease of the immunophilin FKBP 52 in the spinal cord of a transgenic model for amyotrophic lateral sclerosis",

abstract = "Expressions of immunophilin FKBP-12 and FKBP-52 were examined in the spinal cord of transgenic mice with an ALS-linked mutant Cu/Zn superoxide dismutase (SOD1) gene. The immunoreactivity of FKBP-12 was present predominantly in the cytoplasm, but did not show a difference between age-matched wild type and transgenic (Tg) mice at 25 and 35 weeks. In contrast, the immunoreactivity of FKBP-52 was predominantly present in the nucleus, which progressively declined only in the Tg mice as early as an early presymptomatic stage at 25 weeks of age in the anterior horn neurons. The present result suggests that the downregulation of FKBP-52 may be involved in the pathogenesis in the early stages of amyotrophic lateral sclerosis (ALS).",

keywords = "ALS, FKBP-52, Immunophilin, SOD1, Transgenic mouse",

author = "Y. Manabe and H. Warita and T. Murakami and M. Shiote and T. Hayashi and N. Omori and I. Nagano and M. Shoji and K. Abe",

note = "Funding Information: This work was partly supported by Grant-in-Aid for Scientific Research (B) 12470141, (C) 13670649 and (Hoga) 12877211 from the Ministry of Education, Science, Culture and Sports of Japan, Kobayashi Magobe Memorial Medical Foundation, and by grants (K. Tashiro, Y. Itoyama and S. Tsuji), and Comprehensive Research on Aging and Health (H11-Choju-010, No.207; A. Koizumi) from the Ministry of Health and Welfare of Japan.",

year = "2002",

month = may,

day = "10",

doi = "10.1016/S0006-8993(02)02466-6",

language = "English",

volume = "935",

pages = "124--128",

journal = "Molecular Brain Research",

issn = "0006-8993",

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TY - JOUR

T1 - Early decrease of the immunophilin FKBP 52 in the spinal cord of a transgenic model for amyotrophic lateral sclerosis

AU - Manabe, Y.

AU - Warita, H.

AU - Murakami, T.

AU - Shiote, M.

AU - Hayashi, T.

AU - Omori, N.

AU - Nagano, I.

AU - Shoji, M.

AU - Abe, K.

N1 - Funding Information: This work was partly supported by Grant-in-Aid for Scientific Research (B) 12470141, (C) 13670649 and (Hoga) 12877211 from the Ministry of Education, Science, Culture and Sports of Japan, Kobayashi Magobe Memorial Medical Foundation, and by grants (K. Tashiro, Y. Itoyama and S. Tsuji), and Comprehensive Research on Aging and Health (H11-Choju-010, No.207; A. Koizumi) from the Ministry of Health and Welfare of Japan.

PY - 2002/5/10

Y1 - 2002/5/10

N2 - Expressions of immunophilin FKBP-12 and FKBP-52 were examined in the spinal cord of transgenic mice with an ALS-linked mutant Cu/Zn superoxide dismutase (SOD1) gene. The immunoreactivity of FKBP-12 was present predominantly in the cytoplasm, but did not show a difference between age-matched wild type and transgenic (Tg) mice at 25 and 35 weeks. In contrast, the immunoreactivity of FKBP-52 was predominantly present in the nucleus, which progressively declined only in the Tg mice as early as an early presymptomatic stage at 25 weeks of age in the anterior horn neurons. The present result suggests that the downregulation of FKBP-52 may be involved in the pathogenesis in the early stages of amyotrophic lateral sclerosis (ALS).

AB - Expressions of immunophilin FKBP-12 and FKBP-52 were examined in the spinal cord of transgenic mice with an ALS-linked mutant Cu/Zn superoxide dismutase (SOD1) gene. The immunoreactivity of FKBP-12 was present predominantly in the cytoplasm, but did not show a difference between age-matched wild type and transgenic (Tg) mice at 25 and 35 weeks. In contrast, the immunoreactivity of FKBP-52 was predominantly present in the nucleus, which progressively declined only in the Tg mice as early as an early presymptomatic stage at 25 weeks of age in the anterior horn neurons. The present result suggests that the downregulation of FKBP-52 may be involved in the pathogenesis in the early stages of amyotrophic lateral sclerosis (ALS).

KW - ALS

KW - FKBP-52

KW - Immunophilin

KW - SOD1

KW - Transgenic mouse

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