Abstract
Expressions of immunophilin FKBP-12 and FKBP-52 were examined in the spinal cord of transgenic mice with an ALS-linked mutant Cu/Zn superoxide dismutase (SOD1) gene. The immunoreactivity of FKBP-12 was present predominantly in the cytoplasm, but did not show a difference between age-matched wild type and transgenic (Tg) mice at 25 and 35 weeks. In contrast, the immunoreactivity of FKBP-52 was predominantly present in the nucleus, which progressively declined only in the Tg mice as early as an early presymptomatic stage at 25 weeks of age in the anterior horn neurons. The present result suggests that the downregulation of FKBP-52 may be involved in the pathogenesis in the early stages of amyotrophic lateral sclerosis (ALS).
| Original language | English |
|---|---|
| Pages (from-to) | 124-128 |
| Number of pages | 5 |
| Journal | Brain Research |
| Volume | 935 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - May 10 2002 |
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Keywords
- ALS
- FKBP-52
- Immunophilin
- SOD1
- Transgenic mouse
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Early decrease of the immunophilin FKBP 52 in the spinal cord of a transgenic model for amyotrophic lateral sclerosis. / Manabe, Y.; Warita, H.; Murakami, T.; Shiote, M.; Hayashi, T.; Omori, N.; Nagano, I.; Shoji, M.; Abe, Koji.
In: Brain Research, Vol. 935, No. 1-2, 10.05.2002, p. 124-128.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Early decrease of the immunophilin FKBP 52 in the spinal cord of a transgenic model for amyotrophic lateral sclerosis
AU - Manabe, Y.
AU - Warita, H.
AU - Murakami, T.
AU - Shiote, M.
AU - Hayashi, T.
AU - Omori, N.
AU - Nagano, I.
AU - Shoji, M.
AU - Abe, Koji
PY - 2002/5/10
Y1 - 2002/5/10
N2 - Expressions of immunophilin FKBP-12 and FKBP-52 were examined in the spinal cord of transgenic mice with an ALS-linked mutant Cu/Zn superoxide dismutase (SOD1) gene. The immunoreactivity of FKBP-12 was present predominantly in the cytoplasm, but did not show a difference between age-matched wild type and transgenic (Tg) mice at 25 and 35 weeks. In contrast, the immunoreactivity of FKBP-52 was predominantly present in the nucleus, which progressively declined only in the Tg mice as early as an early presymptomatic stage at 25 weeks of age in the anterior horn neurons. The present result suggests that the downregulation of FKBP-52 may be involved in the pathogenesis in the early stages of amyotrophic lateral sclerosis (ALS).
AB - Expressions of immunophilin FKBP-12 and FKBP-52 were examined in the spinal cord of transgenic mice with an ALS-linked mutant Cu/Zn superoxide dismutase (SOD1) gene. The immunoreactivity of FKBP-12 was present predominantly in the cytoplasm, but did not show a difference between age-matched wild type and transgenic (Tg) mice at 25 and 35 weeks. In contrast, the immunoreactivity of FKBP-52 was predominantly present in the nucleus, which progressively declined only in the Tg mice as early as an early presymptomatic stage at 25 weeks of age in the anterior horn neurons. The present result suggests that the downregulation of FKBP-52 may be involved in the pathogenesis in the early stages of amyotrophic lateral sclerosis (ALS).
KW - ALS
KW - FKBP-52
KW - Immunophilin
KW - SOD1
KW - Transgenic mouse
UR - http://www.scopus.com/inward/record.url?scp=0037052635&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037052635&partnerID=8YFLogxK
U2 - 10.1016/S0006-8993(02)02466-6
DO - 10.1016/S0006-8993(02)02466-6
M3 - Article
C2 - 12062482
AN - SCOPUS:0037052635
VL - 935
SP - 124
EP - 128
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1-2
ER -