Early decrease of the immunophilin FKBP 52 in the spinal cord of a transgenic model for amyotrophic lateral sclerosis

Y. Manabe, H. Warita, T. Murakami, M. Shiote, T. Hayashi, N. Omori, I. Nagano, M. Shoji, Koji Abe

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Expressions of immunophilin FKBP-12 and FKBP-52 were examined in the spinal cord of transgenic mice with an ALS-linked mutant Cu/Zn superoxide dismutase (SOD1) gene. The immunoreactivity of FKBP-12 was present predominantly in the cytoplasm, but did not show a difference between age-matched wild type and transgenic (Tg) mice at 25 and 35 weeks. In contrast, the immunoreactivity of FKBP-52 was predominantly present in the nucleus, which progressively declined only in the Tg mice as early as an early presymptomatic stage at 25 weeks of age in the anterior horn neurons. The present result suggests that the downregulation of FKBP-52 may be involved in the pathogenesis in the early stages of amyotrophic lateral sclerosis (ALS).

Original languageEnglish
Pages (from-to)124-128
Number of pages5
JournalBrain Research
Volume935
Issue number1-2
DOIs
Publication statusPublished - May 10 2002

Fingerprint

Immunophilins
Tacrolimus Binding Proteins
Amyotrophic Lateral Sclerosis
Tacrolimus Binding Protein 1A
Transgenic Mice
Spinal Cord
Anterior Horn Cells
Cytoplasm
Down-Regulation
Genes

Keywords

  • ALS
  • FKBP-52
  • Immunophilin
  • SOD1
  • Transgenic mouse

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Early decrease of the immunophilin FKBP 52 in the spinal cord of a transgenic model for amyotrophic lateral sclerosis. / Manabe, Y.; Warita, H.; Murakami, T.; Shiote, M.; Hayashi, T.; Omori, N.; Nagano, I.; Shoji, M.; Abe, Koji.

In: Brain Research, Vol. 935, No. 1-2, 10.05.2002, p. 124-128.

Research output: Contribution to journalArticle

Manabe, Y, Warita, H, Murakami, T, Shiote, M, Hayashi, T, Omori, N, Nagano, I, Shoji, M & Abe, K 2002, 'Early decrease of the immunophilin FKBP 52 in the spinal cord of a transgenic model for amyotrophic lateral sclerosis', Brain Research, vol. 935, no. 1-2, pp. 124-128. https://doi.org/10.1016/S0006-8993(02)02466-6
Manabe, Y. ; Warita, H. ; Murakami, T. ; Shiote, M. ; Hayashi, T. ; Omori, N. ; Nagano, I. ; Shoji, M. ; Abe, Koji. / Early decrease of the immunophilin FKBP 52 in the spinal cord of a transgenic model for amyotrophic lateral sclerosis. In: Brain Research. 2002 ; Vol. 935, No. 1-2. pp. 124-128.
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AU - Hayashi, T.

AU - Omori, N.

AU - Nagano, I.

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