Early decrease of redox factor-1 in spinal motor neurons of presymptomatic transgenic mice with a mutant SOD1 gene

Y. Manabe, H. Warita, T. Murakami, M. Shiote, T. Hayashi, I. Nagano, M. Shoji, K. Abe

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Oxidative stress has been proposed to play a pivotal role in pathogenesis of both sporadic and familial amyotrophic lateral sclerosis (ALS). Expression of DNA repair enzyme redox factor-1 (Ref-1) protein was examined in the spinal cord of transgenic mice with an ALS-linked mutant Cu/Zn superoxide dismutase (SOD1) gene. Immunoblotting and immunocytochemical analyses showed that the most spinal motor neurons lost the immunoreactivity for Ref-1 in the early presymptomatic stage that preceded significant loss of the neurons. The present result suggests that an early impairment of DNA repair in the spinal motor neurons may account for the mutant SOD1-mediated motor neuronal death in this model.

Original languageEnglish
Pages (from-to)104-107
Number of pages4
JournalBrain Research
Volume915
Issue number1
DOIs
Publication statusPublished - Oct 5 2001

Keywords

  • Amyotriphic lateral sclerosis
  • Oxidative stress
  • Redox factor
  • SOD1
  • Transgenic mouse

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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