Early clearance of circulating hepatitis C virus enhanced by induction therapy with twice-a-day intravenous injection of IFN-β

F. Ikeda, H. Shimomura, M. Miyake, S. I. Fujioka, M. Itoh, A. Takahashi, Y. Iwasaki, K. Sakaguchi, K. Yamamoto, T. Higashi, T. Tsuji

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18 Citations (Scopus)

Abstract

To improve the long-term efficacy of interferon (IFN) for treatment of chronic hepatitis C virus (HCV) infection, we proposed induction therapy with twice-a-day IFN-β injection. This study was intended to clarify the antiviral mechanism. Thirty patients were randomly assigned to two groups: group A (twice-a-day therapy) received 3 MU IFN-β intravenously (i.v.) twice a day for 2 weeks; group B (once-a-day therapy) received 6 MU of IFN-β daily. HCV RNA, IFN-β, alanine aminotransferase (ALT), 2'5'-oligoadenylate synthetase (2'5'-AS) activity, and β2-microglobulin in serum were compared between the two groups during the first 2 weeks of IFN therapy. The clearance rate of serum HCV RNA in group A (86.7%) was significantly higher than that in group B (13.3 %) at day 3 (p = 0.0006). No accumulation of IFN-β was shown in serum throughout the therapy. The ratio (day 3/day 1) of 2'5'-AS activity was significantly higher in group A. Multivariate analysis indicated twice-a-day IFN-β injection therapy led to significantly early clearance of circulating HCV. Twice-a-day IFN-β injection therapy could induce biologically enhanced antiviral activities and be an efficient induction therapy for eradication of HCV.

Original languageEnglish
Pages (from-to)831-836
Number of pages6
JournalJournal of Interferon and Cytokine Research
Volume20
Issue number9
DOIs
Publication statusPublished - Oct 13 2000

ASJC Scopus subject areas

  • Immunology
  • Cell Biology
  • Virology

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    Ikeda, F., Shimomura, H., Miyake, M., Fujioka, S. I., Itoh, M., Takahashi, A., Iwasaki, Y., Sakaguchi, K., Yamamoto, K., Higashi, T., & Tsuji, T. (2000). Early clearance of circulating hepatitis C virus enhanced by induction therapy with twice-a-day intravenous injection of IFN-β. Journal of Interferon and Cytokine Research, 20(9), 831-836. https://doi.org/10.1089/10799900050151102