Early afterdepolarization abolished by potassium channel opener in a patient with idiopathic long QT syndrome

T. Sato, Y. Hata, M. Yamamoto, Hiroshi Morita, K. Mizuo, H. Yamanari, D. Saito, T. Ohe

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Abolished Early Afterdepolarization by Nicorandil. We describe a 17-year- old boy with idiopathic long QT syndrome and repeated syncopal episodes. Early afterdepolarization (EAD) in the monophasic action potential (MAP) was demonstrated in the posterior septum of the left ventricle. Injection of the potassium channel opener nicorandil decreased EAD and shortened MAP duration. The syncopal episodes due to ventricular fibrillation disappeared after administration of the potassium channel opener.

Original languageEnglish
Pages (from-to)279-282
Number of pages4
JournalJournal of Cardiovascular Electrophysiology
Volume6
Issue number4
Publication statusPublished - 1995

Fingerprint

Nicorandil
Long QT Syndrome
Potassium Channels
Syncope
Action Potentials
Ventricular Fibrillation
Heart Ventricles
Injections

Keywords

  • early afterdepolarization
  • idiopathic long QT syndrome
  • monophasic action potential
  • potassium channel opener
  • ventricular fibrillation

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Early afterdepolarization abolished by potassium channel opener in a patient with idiopathic long QT syndrome. / Sato, T.; Hata, Y.; Yamamoto, M.; Morita, Hiroshi; Mizuo, K.; Yamanari, H.; Saito, D.; Ohe, T.

In: Journal of Cardiovascular Electrophysiology, Vol. 6, No. 4, 1995, p. 279-282.

Research output: Contribution to journalArticle

Sato, T, Hata, Y, Yamamoto, M, Morita, H, Mizuo, K, Yamanari, H, Saito, D & Ohe, T 1995, 'Early afterdepolarization abolished by potassium channel opener in a patient with idiopathic long QT syndrome', Journal of Cardiovascular Electrophysiology, vol. 6, no. 4, pp. 279-282.
Sato, T. ; Hata, Y. ; Yamamoto, M. ; Morita, Hiroshi ; Mizuo, K. ; Yamanari, H. ; Saito, D. ; Ohe, T. / Early afterdepolarization abolished by potassium channel opener in a patient with idiopathic long QT syndrome. In: Journal of Cardiovascular Electrophysiology. 1995 ; Vol. 6, No. 4. pp. 279-282.
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AU - Yamanari, H.

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