Early Afterdepolarization Abolished by Potassium Channel Opener in a Patient with Idiopathic Long QT Syndrome

TETSUYA SATO, YOSHIKI HATA, MIKA YAMAMOTO, HIROSHI MORITA, KOZO MIZUO, HIROSHI YAMANARI, DAIJI SAITO, TOHRU OHE

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Abolished Early Afterdepolarization by Nicorandil. We describe a 17‐year‐old boy with idiopathic long QT syndrome and repeated syncopal episodes. Early afterdepolarization (EAD) in the monophasic action potential (MAP) was demonstrated in the posterior septum of the left ventricle. Injection of the potassium channel opener nicorandil decreased KAD and shortened MAP duration. The syncopal episodes due to ventricular fibrillation disappeared after administration of the potassium channel opener.

Original languageEnglish
Pages (from-to)279-282
Number of pages4
JournalJournal of Cardiovascular Electrophysiology
Volume6
Issue number4
DOIs
Publication statusPublished - Apr 1995

Keywords

  • early afterdepolarization
  • idiopathic long QT syndrome
  • monophasic action potential
  • potassium channel opener
  • ventricular fibrillation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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