EAAT1 and EAAT2 immunoreactivity in transgenic mice with a G93A mutant SODI gene

Shoichi Sasaki, Hitoshi Warita, Koji Abe, Takashi Komori, Makoto Iwata

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Immunocytochemical and quantitative analyses were used to correlate the localisation of excitatory amino acid transporter proteins EAAT1, EAAT2 with time in spinal motoneurones of presymptomatic and symptomatic mice with the G93A mutant SODI gene. Specimens from age-matched non-transgenic wild-type mice served as controls. EAAT1 and EAAT2 immunoreactivity was well-preserved in the gray matter in both controls and transgenic mice at all ages, and there was no difference in the expression of EAAT1 and EAAT2 immunoreactivity between controls and transgenic mice. These findings suggest that EAAT1 and EAAT2 may not play a pivotal role in the degeneration of motoneurons in this animal model.

Original languageEnglish
Pages (from-to)1359-1362
Number of pages4
JournalNeuroReport
Volume12
Issue number7
Publication statusPublished - May 25 2001

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Motor Neurons
Transgenic Mice
Glutamate Plasma Membrane Transport Proteins
Genes
Animal Models
Gray Matter

Keywords

  • Amyotrophic lateral sclerosis
  • Astroglial glutamate transporter
  • Excitatory amino acid
  • Immunohistochemistry
  • SODI mutant
  • Spinal cord
  • Transgenic mice

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Sasaki, S., Warita, H., Abe, K., Komori, T., & Iwata, M. (2001). EAAT1 and EAAT2 immunoreactivity in transgenic mice with a G93A mutant SODI gene. NeuroReport, 12(7), 1359-1362.

EAAT1 and EAAT2 immunoreactivity in transgenic mice with a G93A mutant SODI gene. / Sasaki, Shoichi; Warita, Hitoshi; Abe, Koji; Komori, Takashi; Iwata, Makoto.

In: NeuroReport, Vol. 12, No. 7, 25.05.2001, p. 1359-1362.

Research output: Contribution to journalArticle

Sasaki, S, Warita, H, Abe, K, Komori, T & Iwata, M 2001, 'EAAT1 and EAAT2 immunoreactivity in transgenic mice with a G93A mutant SODI gene', NeuroReport, vol. 12, no. 7, pp. 1359-1362.
Sasaki S, Warita H, Abe K, Komori T, Iwata M. EAAT1 and EAAT2 immunoreactivity in transgenic mice with a G93A mutant SODI gene. NeuroReport. 2001 May 25;12(7):1359-1362.
Sasaki, Shoichi ; Warita, Hitoshi ; Abe, Koji ; Komori, Takashi ; Iwata, Makoto. / EAAT1 and EAAT2 immunoreactivity in transgenic mice with a G93A mutant SODI gene. In: NeuroReport. 2001 ; Vol. 12, No. 7. pp. 1359-1362.
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