E6-AP/UBE3A protein acts as a ubiquitin ligase toward SOX9 protein

Takako Hattori, Tetsuya Kishino, Shelley Stephen, Heidi Eberspaecher, Sayumi Maki, Masaharu Takigawa, Benoit De Crombrugghe, Hideyo Yasuda

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: Although the ubiquitin-proteasome pathway is thought to regulate the level of SOX9, the ubiquitin ligase involved has not yet been determined. Results: E6-AP/UBE3A was found to bind and ubiquitinate SOX9. Conclusion: E6-AP/UBE3A functions as a ubiquitin ligase toward SOX9 both in vitro and in vivo. Significance: These data provide the regulatory mechanism of the SOX9 level in chondrocytes by ubiquitin ligase.

Original languageEnglish
Pages (from-to)35138-35148
Number of pages11
JournalJournal of Biological Chemistry
Volume288
Issue number49
DOIs
Publication statusPublished - Dec 6 2013

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Ligases
Ubiquitin
Proteins
Proteasome Endopeptidase Complex
Chondrocytes

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

E6-AP/UBE3A protein acts as a ubiquitin ligase toward SOX9 protein. / Hattori, Takako; Kishino, Tetsuya; Stephen, Shelley; Eberspaecher, Heidi; Maki, Sayumi; Takigawa, Masaharu; De Crombrugghe, Benoit; Yasuda, Hideyo.

In: Journal of Biological Chemistry, Vol. 288, No. 49, 06.12.2013, p. 35138-35148.

Research output: Contribution to journalArticle

Hattori, T, Kishino, T, Stephen, S, Eberspaecher, H, Maki, S, Takigawa, M, De Crombrugghe, B & Yasuda, H 2013, 'E6-AP/UBE3A protein acts as a ubiquitin ligase toward SOX9 protein', Journal of Biological Chemistry, vol. 288, no. 49, pp. 35138-35148. https://doi.org/10.1074/jbc.M113.486795
Hattori, Takako ; Kishino, Tetsuya ; Stephen, Shelley ; Eberspaecher, Heidi ; Maki, Sayumi ; Takigawa, Masaharu ; De Crombrugghe, Benoit ; Yasuda, Hideyo. / E6-AP/UBE3A protein acts as a ubiquitin ligase toward SOX9 protein. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 49. pp. 35138-35148.
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AU - De Crombrugghe, Benoit

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