Dystonin deficiency reduces taste buds and fungiform papillae in the anterior part of the tongue

H. Ichikawa, R. Terayama, T. Yamaai, Y. De Repentigny, R. Kothary, T. Sugimoto

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The anterior part of the tongue was examined in wild type and dystonia musculorum mice to assess the effect of dystonin loss on fungiform papillae. In the mutant mouse, the density of fungiform papillae and their taste buds was severely decreased when compared to wild type littermates (papilla, 67% reduction; taste bud, 77% reduction). The mutation also reduced the size of these papillae (17% reduction) and taste buds (29% reduction). In addition, immunohistochemical analysis demonstrated that the dystonin mutation reduced the number of PGP 9.5 and calbindin D28k-containing nerve fibers in fungiform papillae. These data together suggest that dystonin is required for the innervation and development of fungiform papillae and taste buds.

Original languageEnglish
Pages (from-to)142-146
Number of pages5
JournalBrain Research
Volume1129
Issue number1
DOIs
Publication statusPublished - Jan 19 2007

Fingerprint

Taste Buds
Tongue
Calbindin 1
Mutation
Dystonia
Nerve Fibers
Dystonin

Keywords

  • Calbindin D-28k
  • Dystonin
  • Fungiform papilla
  • Immunohistochemistry
  • Mutant mouse
  • PGP 9.5
  • Taste bud

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Developmental Biology
  • Molecular Biology

Cite this

Ichikawa, H., Terayama, R., Yamaai, T., De Repentigny, Y., Kothary, R., & Sugimoto, T. (2007). Dystonin deficiency reduces taste buds and fungiform papillae in the anterior part of the tongue. Brain Research, 1129(1), 142-146. https://doi.org/10.1016/j.brainres.2006.04.044

Dystonin deficiency reduces taste buds and fungiform papillae in the anterior part of the tongue. / Ichikawa, H.; Terayama, R.; Yamaai, T.; De Repentigny, Y.; Kothary, R.; Sugimoto, T.

In: Brain Research, Vol. 1129, No. 1, 19.01.2007, p. 142-146.

Research output: Contribution to journalArticle

Ichikawa, H, Terayama, R, Yamaai, T, De Repentigny, Y, Kothary, R & Sugimoto, T 2007, 'Dystonin deficiency reduces taste buds and fungiform papillae in the anterior part of the tongue', Brain Research, vol. 1129, no. 1, pp. 142-146. https://doi.org/10.1016/j.brainres.2006.04.044
Ichikawa H, Terayama R, Yamaai T, De Repentigny Y, Kothary R, Sugimoto T. Dystonin deficiency reduces taste buds and fungiform papillae in the anterior part of the tongue. Brain Research. 2007 Jan 19;1129(1):142-146. https://doi.org/10.1016/j.brainres.2006.04.044
Ichikawa, H. ; Terayama, R. ; Yamaai, T. ; De Repentigny, Y. ; Kothary, R. ; Sugimoto, T. / Dystonin deficiency reduces taste buds and fungiform papillae in the anterior part of the tongue. In: Brain Research. 2007 ; Vol. 1129, No. 1. pp. 142-146.
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