Dysregulation of autoimmunity caused by silica exposure and alteration of Fas-mediated apoptosis in T lymphocytes derived from silicosis patients.

T. Otsuki, H. Hayashi, Y. Nishimura, F. Hyodo, Megumi Maeda, N. Kumagai, Y. Miura, M. Kusaka, K. Uragami

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Silicosis patients suffer from pulmonary fibrosis caused by silica inhalation, as well as autoimmune diseases known as the adjuvant effects of silica. Caplan syndrome complicated with rheumatoid arthritis (RA) is well known epidemiologically, and the incidence of complicated systemic sclerosis (SSc), systemic lupus erythematosus (SLE) and antineutrophilic cytoplasmic antibody (ANCA)-related nephritis have been reported frequently in silicosis patients. To explore the detailed mechanisms of silica-induced dysregulation of autoimmunity, we had focused on Fas/CD95 and Fas-mediated apoptosis because Fas is one of the most important molecules regarding apoptosis of lymphocytes and its alteration makes some T cells survive longer. Additionally, if the long-survived T cells include the self-recognizing T-cell clones, it is easily thought that autoimmune diseases will appear in this situation. Furthermore, regulatory T cells (Treg) showing CD4+25+ and forkhead box P3 (FoxP3)-positive have been a central player in regulating activation of self- and foreign-antigen recognizing T cells, and it has been reported that activation of Treg causes its higher expression of Fas/CD95. Thus, in this review, we introduce the alteration of Fas and related molecules as found in silicosis and also present the Treg function of the CD4+25+ fraction in peripheral blood mononuclear cells derived from silicosis patients.

Original languageEnglish
JournalInternational Journal of Immunopathology and Pharmacology
Volume24
Issue number1 Suppl
Publication statusPublished - Jan 2011
Externally publishedYes

Fingerprint

Silicosis
Autoimmunity
Silicon Dioxide
Apoptosis
T-Lymphocytes
Autoimmune Diseases
Caplan Syndrome
Nephritis
Pulmonary Fibrosis
Systemic Scleroderma
Autoantigens
Regulatory T-Lymphocytes
Systemic Lupus Erythematosus
Inhalation
Blood Cells
Rheumatoid Arthritis
Clone Cells
Lymphocytes
Antibodies
Incidence

ASJC Scopus subject areas

  • Pharmacology
  • Immunology
  • Immunology and Allergy

Cite this

Dysregulation of autoimmunity caused by silica exposure and alteration of Fas-mediated apoptosis in T lymphocytes derived from silicosis patients. / Otsuki, T.; Hayashi, H.; Nishimura, Y.; Hyodo, F.; Maeda, Megumi; Kumagai, N.; Miura, Y.; Kusaka, M.; Uragami, K.

In: International Journal of Immunopathology and Pharmacology, Vol. 24, No. 1 Suppl, 01.2011.

Research output: Contribution to journalArticle

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AU - Maeda, Megumi

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AU - Miura, Y.

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