Dynamical properties of autoimmune disease models: Tolerance, flare-up, dormancy

Shingo Iwami, Yasuhiro Takeuchi, Yoshiharu Miura, Toru Sasaki, Tsuyoshi Kajiwara

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The mechanisms of autoimmune disease have remained puzzling for a long time. Here we construct a simple mathematical model for autoimmune disease based on the personal immune response function and the target cell growth function. We show that these two functions are sufficient to capture the essence of autoimmune disease and can explain characteristic symptom phases such as tolerance, repeated flare-ups and dormancy. Our results strongly suggest that a more complete understanding of these two functions will underlie the development of an effective therapy for autoimmune disease.

Original languageEnglish
Pages (from-to)646-659
Number of pages14
JournalJournal of Theoretical Biology
Volume246
Issue number4
DOIs
Publication statusPublished - Jun 21 2007

Keywords

  • Autoimmune disease
  • Dormancy
  • Flare-up
  • Mathematical model
  • Tolerance

ASJC Scopus subject areas

  • Statistics and Probability
  • Modelling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

Fingerprint Dive into the research topics of 'Dynamical properties of autoimmune disease models: Tolerance, flare-up, dormancy'. Together they form a unique fingerprint.

Cite this