Dynamic view of the nuclear matrix

Kimiko M. Tsutsui, Kuniaki Sano, Ken Tsutsui

Research output: Contribution to journalReview article

42 Citations (Scopus)

Abstract

The nuclear matrix is an operationally defined nuclear skeletal structure that is believed to be involved in many nuclear functions including DNA replication, transcription, repair, and pre-mRNA processing/transport. Until relatively recently, the nuclear matrix was thought to be a rigid and static structure, but it is now thought to be dynamic. This paradigm shift was based in part on the tracking of the intranuclear movement of proteins tagged with fluorochromes. In this review, we attempt to redefine the nuclear matrix in light of recent findings and describe some useful techniques for the dynamic analysis of nuclear function. Copyright

Original languageEnglish
Pages (from-to)113-120
Number of pages8
JournalActa medica Okayama
Volume59
Issue number4
Publication statusPublished - Aug 1 2005

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Keywords

  • Chromatin
  • Histone modification
  • MAR
  • Nuclear matrix
  • Topoisomerase

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Tsutsui, K. M., Sano, K., & Tsutsui, K. (2005). Dynamic view of the nuclear matrix. Acta medica Okayama, 59(4), 113-120.