Dynamic Reorganization of Microtubule and Glioma Invasion

Yoshihiro Otani, Tomotsugu Ichikawa, Kazuhiko Kurozumi, Isao Date

Research output: Contribution to journalReview article

Abstract

Gliomas are characterized as highly diffuse infiltrating tumors, and currently available treatments such as surgery, radiation and chemotherapy are unfeasible or show limited efficacy against these tumors. Recent genetic and epigenetic analyses of glioma have revealed increasing evidence of the role of driver genetic alterations in glioma development and led to the identification of prognostic factors. Despite these findings, the survival rates of glioma patients remain low, and alternative treatments and novel targets are needed. Recent studies identified neural stem cells as the possible origin of gliomas, and some evidence has revealed shared functions and mechanisms between glioma cells and neurons, also supporting their similarity. The cytoskeleton plays important roles in the migration of normal cells as well as cancer cells. Recent reports have described a role for microtubules, a component of the cytoskeleton, in glioma invasion. Notably, several factors that regulate microtubule functions, such as microtubule-associated proteins, plus-end tracking proteins, or motor proteins, are upregulated in glioma tissues compared with normal tissue, and upregulation of these factors is associated with high invasiveness of glioma cells. In this review, we describe the mechanism of microtubules in glioma invasion and discuss the possibility of microtubule-targeted therapy to inhibit glioma invasion.

Original languageEnglish
Pages (from-to)285-297
Number of pages13
JournalActa medica Okayama
Volume73
Issue number4
DOIs
Publication statusPublished - Aug 1 2019

Fingerprint

Glioma
Microtubules
Tumors
Cells
Microtubule-Associated Proteins
Chemotherapy
Thromboplastin
Stem cells
Surgery
Neurons
Proteins
Tissue
Radiation
Cytoskeleton
Neoplasms
Neural Stem Cells
Epigenomics
Cell Movement
Up-Regulation
Therapeutics

Keywords

  • cytoskeletons
  • glioma
  • invasion
  • microtubules

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Dynamic Reorganization of Microtubule and Glioma Invasion. / Otani, Yoshihiro; Ichikawa, Tomotsugu; Kurozumi, Kazuhiko; Date, Isao.

In: Acta medica Okayama, Vol. 73, No. 4, 01.08.2019, p. 285-297.

Research output: Contribution to journalReview article

Otani, Yoshihiro ; Ichikawa, Tomotsugu ; Kurozumi, Kazuhiko ; Date, Isao. / Dynamic Reorganization of Microtubule and Glioma Invasion. In: Acta medica Okayama. 2019 ; Vol. 73, No. 4. pp. 285-297.
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