Dynamic modulation of epileptic high frequency oscillations by the phase of slower cortical rhythms

George M. Ibrahim, Simeon M. Wong, Ryan A. Anderson, Gabrielle Singh-Cadieux, Tomoyuki Akiyama, Ayako Ochi, Hiroshi Otsubo, Tohru Okanishi, Taufik A. Valiante, Elizabeth Donner, James T. Rutka, O. Carter Snead, Sam M. Doesburg

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Pathological high frequency oscillations (pHFOs) have been proposed to be robust markers of epileptic cortex. Oscillatory activity below this frequency range has been shown to be modulated by phase of lower frequency oscillations. Here, we tested the hypothesis that dynamic cross-frequency interactions involving pHFOs are concentrated within the epileptogenic cortex. Intracranial electroencephalographic recordings from 17 children with medically-intractable epilepsy secondary to focal cortical dysplasia were obtained. A time-resolved analysis was performed to determine topographic concentrations and dynamic changes in cross-frequency amplitude-to-phase coupling (CFC). CFC between pHFOs and the phase of theta and alpha rhythms was found to be significantly elevated in the seizure-onset zone compared to non-epileptic regions (p.

Original languageEnglish
Pages (from-to)30-38
Number of pages9
JournalExperimental Neurology
Volume251
DOIs
Publication statusPublished - Jan 2014
Externally publishedYes

Fingerprint

Alpha Rhythm
Theta Rhythm
Malformations of Cortical Development
Seizures
Drug Resistant Epilepsy

Keywords

  • Cross-frequency coupling
  • Epilepsy
  • HFOs
  • High frequency oscillations
  • Intracranial EEG
  • Networks
  • Seizure

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

Cite this

Dynamic modulation of epileptic high frequency oscillations by the phase of slower cortical rhythms. / Ibrahim, George M.; Wong, Simeon M.; Anderson, Ryan A.; Singh-Cadieux, Gabrielle; Akiyama, Tomoyuki; Ochi, Ayako; Otsubo, Hiroshi; Okanishi, Tohru; Valiante, Taufik A.; Donner, Elizabeth; Rutka, James T.; Snead, O. Carter; Doesburg, Sam M.

In: Experimental Neurology, Vol. 251, 01.2014, p. 30-38.

Research output: Contribution to journalArticle

Ibrahim, GM, Wong, SM, Anderson, RA, Singh-Cadieux, G, Akiyama, T, Ochi, A, Otsubo, H, Okanishi, T, Valiante, TA, Donner, E, Rutka, JT, Snead, OC & Doesburg, SM 2014, 'Dynamic modulation of epileptic high frequency oscillations by the phase of slower cortical rhythms', Experimental Neurology, vol. 251, pp. 30-38. https://doi.org/10.1016/j.expneurol.2013.10.019
Ibrahim, George M. ; Wong, Simeon M. ; Anderson, Ryan A. ; Singh-Cadieux, Gabrielle ; Akiyama, Tomoyuki ; Ochi, Ayako ; Otsubo, Hiroshi ; Okanishi, Tohru ; Valiante, Taufik A. ; Donner, Elizabeth ; Rutka, James T. ; Snead, O. Carter ; Doesburg, Sam M. / Dynamic modulation of epileptic high frequency oscillations by the phase of slower cortical rhythms. In: Experimental Neurology. 2014 ; Vol. 251. pp. 30-38.
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