Dynamic characteristics of heart rate control by the autonomic nervous system in rats

Masaki Mizuno, Toru Kawada, Atsunori Kamiya, Tadayoshi Miyamoto, Shuji Shimizu, Toshiaki Shishido, Scott A. Smith, Masaru Sugimachi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We estimated the transfer function of autonomic heart rate (HR) control by using random binary sympathetic or vagal nerve stimulation in anaesthetized rats. The transfer function from sympathetic stimulation to HR response approximated a second-order, low-pass filter with a lag time (gain, 4.29 ± 1.55 beats min-1 Hz-1; natural frequency, 0.07 ± 0.03 Hz; damping coefficient, 1.96 ± 0.64; and lag time, 0.73 ± 0.12 s). The transfer function from vagal stimulation to HR response approximated a first-order, low-pass filter with a lag time (gain, 8.84 ± 4.51 beats min-1 Hz-1; corner frequency, 0.12 ± 0.06 Hz; and lag time, 0.12 ± 0.08 s). These results suggest that the dynamic characteristics of HR control by the autonomic nervous system in rats are similar to those of larger mammals.

Original languageEnglish
Pages (from-to)919-925
Number of pages7
JournalExperimental Physiology
Volume95
Issue number9
DOIs
Publication statusPublished - Sep 1 2010
Externally publishedYes

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Autonomic Nervous System
Heart Rate
Vagus Nerve Stimulation
Mammals

ASJC Scopus subject areas

  • Physiology

Cite this

Mizuno, M., Kawada, T., Kamiya, A., Miyamoto, T., Shimizu, S., Shishido, T., ... Sugimachi, M. (2010). Dynamic characteristics of heart rate control by the autonomic nervous system in rats. Experimental Physiology, 95(9), 919-925. https://doi.org/10.1113/expphysiol.2010.053090

Dynamic characteristics of heart rate control by the autonomic nervous system in rats. / Mizuno, Masaki; Kawada, Toru; Kamiya, Atsunori; Miyamoto, Tadayoshi; Shimizu, Shuji; Shishido, Toshiaki; Smith, Scott A.; Sugimachi, Masaru.

In: Experimental Physiology, Vol. 95, No. 9, 01.09.2010, p. 919-925.

Research output: Contribution to journalArticle

Mizuno, M, Kawada, T, Kamiya, A, Miyamoto, T, Shimizu, S, Shishido, T, Smith, SA & Sugimachi, M 2010, 'Dynamic characteristics of heart rate control by the autonomic nervous system in rats', Experimental Physiology, vol. 95, no. 9, pp. 919-925. https://doi.org/10.1113/expphysiol.2010.053090
Mizuno, Masaki ; Kawada, Toru ; Kamiya, Atsunori ; Miyamoto, Tadayoshi ; Shimizu, Shuji ; Shishido, Toshiaki ; Smith, Scott A. ; Sugimachi, Masaru. / Dynamic characteristics of heart rate control by the autonomic nervous system in rats. In: Experimental Physiology. 2010 ; Vol. 95, No. 9. pp. 919-925.
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