Dynamic cerebrospinal fluid flow on MRI in cortical cerebellar atrophy and multiple system atrophy-cerebellar type

Yusuke Fukui, Nozomi Hishikawa, Kota Sato, Syoichiro Kono, Kosuke Matsuzono, Yumik Nakano, Yasuyuki Ohta, Toru Yamashita, Kentaro Deguchi, Koji Abe

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective The purpose of this study was to examine a new MRI technology, dynamic cerebrospinal fluid (CSF) flow, to examine sporadic cerebellar ataxia patients with cortical cerebellar atrophy (CCA) and multiple system atrophy-cerebellar type (MSA-C). Methods Nine CCA patients (3 men and 6 women; mean age: 64.2±6.9 years) and 31 MSA-C patients (13 men and 18 women; mean age: 62.7±6.8 years) were examined by a dynamic CSF flow analysis. All CSF flow data were evaluated by phase contrast-MRI using a 1.5T MRI scanner. The CSF flow was calculated by 15 images in the equidistant MRI sequence which was taken through a cardiac cycle. Results Compared with the CCA patients, the absolute values of the mean velocity of the MSA-C patients were significantly reduced at time points 5 (CCA, 0.24±0.14 cm/s; MSA-C, 0.13±0.11 cm/s;* p** p* p** p** p

Original languageEnglish
Pages (from-to)1717-1723
Number of pages7
JournalInternal Medicine
Volume54
Issue number14
DOIs
Publication statusPublished - Jul 15 2015

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Multiple System Atrophy
Atrophy
Cerebrospinal Fluid
Cerebellar Ataxia
Technology

Keywords

  • Cerebrospinal fluid
  • Cortical cerebellar atrophy
  • Multiple system atrophy-cerebellar type
  • Multiple system atrophy-parkinsonian type
  • Phase contrast-magnetic resonance imaging

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Dynamic cerebrospinal fluid flow on MRI in cortical cerebellar atrophy and multiple system atrophy-cerebellar type. / Fukui, Yusuke; Hishikawa, Nozomi; Sato, Kota; Kono, Syoichiro; Matsuzono, Kosuke; Nakano, Yumik; Ohta, Yasuyuki; Yamashita, Toru; Deguchi, Kentaro; Abe, Koji.

In: Internal Medicine, Vol. 54, No. 14, 15.07.2015, p. 1717-1723.

Research output: Contribution to journalArticle

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AU - Matsuzono, Kosuke

AU - Nakano, Yumik

AU - Ohta, Yasuyuki

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