Abstract
Background: Follicular lymphomas occasionally arise in the extra-nodal organs and are frequently found in the duodenum. They are often localised tumours with multiple polyps around the ampulla of Vater. Aims: To examine a IgH/bcl-2 hybrid gene and VH gene to investigate the nature of the lymphoma cells and how they differ from nodal follicular lymphomas and MALT lymphomas. Methods: Of 40 patients reported previously, 35 with duodenal follicular lymphoma were studied in detail with respect to clinicopathological characteristics. Results: 37/40 patients were in clinical stage I (n = 30) or stage II (n = 7). Clonal immunoglobulin gene rearrangement was detected in 53.3% of examined cases, and rearrangement of IgH/bcl-2 gene at the major break point was detected in 27% of cases. Three of 8 examined cases were VH4 (38%); 2 out of them were VH4-34. As VH4 deviation is one of the common characteristics of MALT lymphomas and 2/3 were identical, duodenal follicular lymphomas have a similar aetiology to MALT lymphomas. Clinical course was also similar to that of MALT lymphomas. Conclusions: Results suggest that duodenal follicular lymphomas have intermediate characteristics of MALT lymphomas and nodal follicular lymphomas.
| Original language | English |
|---|---|
| Pages (from-to) | 377-381 |
| Number of pages | 5 |
| Journal | Journal of Clinical Pathology |
| Volume | 61 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 2008 |
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ASJC Scopus subject areas
- Pathology and Forensic Medicine
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Duodenal follicular lymphomas share common characteristics with mucosa-associated lymphoid tissue lymphomas. / Sato, Yasuharu; Ichimura, K.; Tanaka, Takehiro; Takata, K.; Morito, T.; Sato, H.; Sato, Y.; Kondo, E.; Yanai, Hiroyuki; Ohara, N.; Oka, Takashi; Yoshino, Tadashi.
In: Journal of Clinical Pathology, Vol. 61, No. 3, 03.2008, p. 377-381.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Duodenal follicular lymphomas share common characteristics with mucosa-associated lymphoid tissue lymphomas
AU - Sato, Yasuharu
AU - Ichimura, K.
AU - Tanaka, Takehiro
AU - Takata, K.
AU - Morito, T.
AU - Sato, H.
AU - Sato, Y.
AU - Kondo, E.
AU - Yanai, Hiroyuki
AU - Ohara, N.
AU - Oka, Takashi
AU - Yoshino, Tadashi
PY - 2008/3
Y1 - 2008/3
N2 - Background: Follicular lymphomas occasionally arise in the extra-nodal organs and are frequently found in the duodenum. They are often localised tumours with multiple polyps around the ampulla of Vater. Aims: To examine a IgH/bcl-2 hybrid gene and VH gene to investigate the nature of the lymphoma cells and how they differ from nodal follicular lymphomas and MALT lymphomas. Methods: Of 40 patients reported previously, 35 with duodenal follicular lymphoma were studied in detail with respect to clinicopathological characteristics. Results: 37/40 patients were in clinical stage I (n = 30) or stage II (n = 7). Clonal immunoglobulin gene rearrangement was detected in 53.3% of examined cases, and rearrangement of IgH/bcl-2 gene at the major break point was detected in 27% of cases. Three of 8 examined cases were VH4 (38%); 2 out of them were VH4-34. As VH4 deviation is one of the common characteristics of MALT lymphomas and 2/3 were identical, duodenal follicular lymphomas have a similar aetiology to MALT lymphomas. Clinical course was also similar to that of MALT lymphomas. Conclusions: Results suggest that duodenal follicular lymphomas have intermediate characteristics of MALT lymphomas and nodal follicular lymphomas.
AB - Background: Follicular lymphomas occasionally arise in the extra-nodal organs and are frequently found in the duodenum. They are often localised tumours with multiple polyps around the ampulla of Vater. Aims: To examine a IgH/bcl-2 hybrid gene and VH gene to investigate the nature of the lymphoma cells and how they differ from nodal follicular lymphomas and MALT lymphomas. Methods: Of 40 patients reported previously, 35 with duodenal follicular lymphoma were studied in detail with respect to clinicopathological characteristics. Results: 37/40 patients were in clinical stage I (n = 30) or stage II (n = 7). Clonal immunoglobulin gene rearrangement was detected in 53.3% of examined cases, and rearrangement of IgH/bcl-2 gene at the major break point was detected in 27% of cases. Three of 8 examined cases were VH4 (38%); 2 out of them were VH4-34. As VH4 deviation is one of the common characteristics of MALT lymphomas and 2/3 were identical, duodenal follicular lymphomas have a similar aetiology to MALT lymphomas. Clinical course was also similar to that of MALT lymphomas. Conclusions: Results suggest that duodenal follicular lymphomas have intermediate characteristics of MALT lymphomas and nodal follicular lymphomas.
UR - http://www.scopus.com/inward/record.url?scp=40449129379&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=40449129379&partnerID=8YFLogxK
U2 - 10.1136/jcp.2007.049825
DO - 10.1136/jcp.2007.049825
M3 - Article
C2 - 17601964
AN - SCOPUS:40449129379
VL - 61
SP - 377
EP - 381
JO - Journal of Clinical Pathology - Clinical Molecular Pathology
JF - Journal of Clinical Pathology - Clinical Molecular Pathology
SN - 0021-9746
IS - 3
ER -