Duodenal follicular lymphomas share common characteristics with mucosa-associated lymphoid tissue lymphomas

Yasuharu Sato, K. Ichimura, Takehiro Tanaka, K. Takata, T. Morito, H. Sato, Y. Sato, E. Kondo, Hiroyuki Yanai, N. Ohara, Takashi Oka, Tadashi Yoshino

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Abstract

Background: Follicular lymphomas occasionally arise in the extra-nodal organs and are frequently found in the duodenum. They are often localised tumours with multiple polyps around the ampulla of Vater. Aims: To examine a IgH/bcl-2 hybrid gene and VH gene to investigate the nature of the lymphoma cells and how they differ from nodal follicular lymphomas and MALT lymphomas. Methods: Of 40 patients reported previously, 35 with duodenal follicular lymphoma were studied in detail with respect to clinicopathological characteristics. Results: 37/40 patients were in clinical stage I (n = 30) or stage II (n = 7). Clonal immunoglobulin gene rearrangement was detected in 53.3% of examined cases, and rearrangement of IgH/bcl-2 gene at the major break point was detected in 27% of cases. Three of 8 examined cases were VH4 (38%); 2 out of them were VH4-34. As VH4 deviation is one of the common characteristics of MALT lymphomas and 2/3 were identical, duodenal follicular lymphomas have a similar aetiology to MALT lymphomas. Clinical course was also similar to that of MALT lymphomas. Conclusions: Results suggest that duodenal follicular lymphomas have intermediate characteristics of MALT lymphomas and nodal follicular lymphomas.

Original languageEnglish
Pages (from-to)377-381
Number of pages5
JournalJournal of Clinical Pathology
Volume61
Issue number3
DOIs
Publication statusPublished - Mar 2008

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Marginal Zone B-Cell Lymphoma
Follicular Lymphoma
bcl-2 Genes
Ampulla of Vater
Immunoglobulin Genes
Gene Rearrangement
Polyps
Duodenum
Lymphoma
Genes
Neoplasms

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Duodenal follicular lymphomas share common characteristics with mucosa-associated lymphoid tissue lymphomas. / Sato, Yasuharu; Ichimura, K.; Tanaka, Takehiro; Takata, K.; Morito, T.; Sato, H.; Sato, Y.; Kondo, E.; Yanai, Hiroyuki; Ohara, N.; Oka, Takashi; Yoshino, Tadashi.

In: Journal of Clinical Pathology, Vol. 61, No. 3, 03.2008, p. 377-381.

Research output: Contribution to journalArticle

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T1 - Duodenal follicular lymphomas share common characteristics with mucosa-associated lymphoid tissue lymphomas

AU - Sato, Yasuharu

AU - Ichimura, K.

AU - Tanaka, Takehiro

AU - Takata, K.

AU - Morito, T.

AU - Sato, H.

AU - Sato, Y.

AU - Kondo, E.

AU - Yanai, Hiroyuki

AU - Ohara, N.

AU - Oka, Takashi

AU - Yoshino, Tadashi

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N2 - Background: Follicular lymphomas occasionally arise in the extra-nodal organs and are frequently found in the duodenum. They are often localised tumours with multiple polyps around the ampulla of Vater. Aims: To examine a IgH/bcl-2 hybrid gene and VH gene to investigate the nature of the lymphoma cells and how they differ from nodal follicular lymphomas and MALT lymphomas. Methods: Of 40 patients reported previously, 35 with duodenal follicular lymphoma were studied in detail with respect to clinicopathological characteristics. Results: 37/40 patients were in clinical stage I (n = 30) or stage II (n = 7). Clonal immunoglobulin gene rearrangement was detected in 53.3% of examined cases, and rearrangement of IgH/bcl-2 gene at the major break point was detected in 27% of cases. Three of 8 examined cases were VH4 (38%); 2 out of them were VH4-34. As VH4 deviation is one of the common characteristics of MALT lymphomas and 2/3 were identical, duodenal follicular lymphomas have a similar aetiology to MALT lymphomas. Clinical course was also similar to that of MALT lymphomas. Conclusions: Results suggest that duodenal follicular lymphomas have intermediate characteristics of MALT lymphomas and nodal follicular lymphomas.

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