Duodenal follicular lymphomas share common characteristics with mucosa-associated lymphoid tissue lymphomas

Y. Sato, K. Ichimura, T. Tanaka, Katsuyoshi Takata, T. Morito, Hiaki Satou, Y. Sato, E. Kondo, H. Yanai, N. Ohara, T. Oka, Tadashi Yoshino

Research output: Contribution to journalArticlepeer-review

67 Citations (Scopus)


Background: Follicular lymphomas occasionally arise in the extra-nodal organs and are frequently found in the duodenum. They are often localised tumours with multiple polyps around the ampulla of Vater. Aims: To examine a IgH/bcl-2 hybrid gene and VH gene to investigate the nature of the lymphoma cells and how they differ from nodal follicular lymphomas and MALT lymphomas. Methods: Of 40 patients reported previously, 35 with duodenal follicular lymphoma were studied in detail with respect to clinicopathological characteristics. Results: 37/40 patients were in clinical stage I (n = 30) or stage II (n = 7). Clonal immunoglobulin gene rearrangement was detected in 53.3% of examined cases, and rearrangement of IgH/bcl-2 gene at the major break point was detected in 27% of cases. Three of 8 examined cases were VH4 (38%); 2 out of them were VH4-34. As VH4 deviation is one of the common characteristics of MALT lymphomas and 2/3 were identical, duodenal follicular lymphomas have a similar aetiology to MALT lymphomas. Clinical course was also similar to that of MALT lymphomas. Conclusions: Results suggest that duodenal follicular lymphomas have intermediate characteristics of MALT lymphomas and nodal follicular lymphomas.

Original languageEnglish
Pages (from-to)377-381
Number of pages5
JournalJournal of Clinical Pathology
Issue number3
Publication statusPublished - Mar 2008

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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