Duodenal and nodal follicular lymphomas are distinct: The former lacks activation-induced cytidine deaminase and follicular dendritic cells despite ongoing somatic hypermutations

Katsuyoshi Takata, Yasuharu Sato, Naoya Nakamura, Yara Yukie Kikuti, Koichi Ichimura, Takehiro Tanaka, Toshiaki Morito, Maiko Tamura, Takashi Oka, Eisaku Kondo, Hiroyuki Okada, Akira Tari, Tadashi Yoshino

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Although most follicular lymphomas are believed to be of nodal origin, they sometimes originate from the duodenum. We have reported that the latter differ from nodal follicular lymphomas in having lower clinical stages and uniformly low histological grades, along with variable region of immunoglobulin heavy chain gene (VH) usage that is more similar to mucosa-associated lymphoid tissue (MALT) lymphomas. Little is known, however, about whether they possess other characteristics of nodal follicular lymphomas, particularly ongoing mutations with follicular dendritic cells. We examined 17 cases for which PCR identified the monoclonal bands of the immunoglobulin gene. The duodenal cases showed ongoing mutations, but they lacked activation-induced cytidine deaminase (AID) expression, a statistically significant difference from the nodal cases (P0.001), and their follicular dendritic cell networks were disrupted. Moreover, not only were VH deviations observed but also they used very restricted VH genes. Although the mechanisms of ongoing mutation without AID and follicular dendritic cell were not clarified, restricted VH usage strongly suggested that antigen stimulation was involved, and that was similar to MALT lymphomas. In conclusion, duodenal follicular lymphomas were shown to be unique, in that they had ongoing hypermutations such as nodal cases, but the mechanisms involved in the hypermutation were quite different; furthermore, restricted VH usage suggested a strong similarity to the antigen-dependent origin of MALT lymphomas.

Original languageEnglish
Pages (from-to)940-949
Number of pages10
JournalModern Pathology
Volume22
Issue number7
DOIs
Publication statusPublished - Jul 2009

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Follicular Dendritic Cells
Follicular Lymphoma
Marginal Zone B-Cell Lymphoma
Mutation
Immunoglobulin Heavy Chain Genes
Antigens
Immunoglobulin Genes
Duodenum
Polymerase Chain Reaction
AICDA (activation-induced cytidine deaminase)
Genes

Keywords

  • AID
  • Duodenal follicular lymphoma
  • Follicular dendritic cell

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Duodenal and nodal follicular lymphomas are distinct : The former lacks activation-induced cytidine deaminase and follicular dendritic cells despite ongoing somatic hypermutations. / Takata, Katsuyoshi; Sato, Yasuharu; Nakamura, Naoya; Kikuti, Yara Yukie; Ichimura, Koichi; Tanaka, Takehiro; Morito, Toshiaki; Tamura, Maiko; Oka, Takashi; Kondo, Eisaku; Okada, Hiroyuki; Tari, Akira; Yoshino, Tadashi.

In: Modern Pathology, Vol. 22, No. 7, 07.2009, p. 940-949.

Research output: Contribution to journalArticle

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