Duffy antigen is important for the lethal effect of the lethal strain of Plasmodium yoelii 17XL

Nobuyoshi Akimitsu, Hye Sook Kim, Hiroshi Hamamoto, Koushirou Kamura, Nobuko Fukuma, Nagisa Arimitsu, Kanako Ono, Yusuke Wataya, Motomi Torii, Kazuhisa Sekimizu

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We studied the potential role of the Duffy antigen and glycophorin A as receptors for rodent malaria parasite invasion of erythrocytes. Parasitemia increased exponentially after infection with Plasmodium berghei NK65, P. chabaudi, and P. vinckei in Duffy antigen knockout, glycophorin A knockout, and wild-type mice, indicating that the Duffy antigen and glycophorin A are not essential for these malaria parasites. However, parasitemia of the Duffy antigen knockout mice infected with P. yoelii 17XL remained constant from day 5 to 14 after infection, and then decreased, resulting in autotherapy. The treatment of P. yoelii 17XL-infected Duffy antigen knockout mice with anti-CD4 antibody increased the parasitemia 15 days after infection and the mice eventually died, indicating that CD-4-positive cells play an important role in the clearance of P. yoelii 17XL at the late stage of the infection.

Original languageEnglish
Pages (from-to)499-503
Number of pages5
JournalParasitology Research
Volume93
Issue number6
DOIs
Publication statusPublished - Aug 1 2004

ASJC Scopus subject areas

  • Parasitology
  • veterinary(all)
  • Insect Science
  • Infectious Diseases

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    Akimitsu, N., Kim, H. S., Hamamoto, H., Kamura, K., Fukuma, N., Arimitsu, N., Ono, K., Wataya, Y., Torii, M., & Sekimizu, K. (2004). Duffy antigen is important for the lethal effect of the lethal strain of Plasmodium yoelii 17XL. Parasitology Research, 93(6), 499-503. https://doi.org/10.1007/s00436-004-1165-x