Duffy antigen is important for the lethal effect of the lethal strain of Plasmodium yoelii 17XL

Nobuyoshi Akimitsu, Hye-Sook Kim, Hiroshi Hamamoto, Koushirou Kamura, Nobuko Fukuma, Nagisa Arimitsu, Kanako Ono, Yusuke Wataya, Motomi Torii, Kazuhisa Sekimizu

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Abstract

We studied the potential role of the Duffy antigen and glycophorin A as receptors for rodent malaria parasite invasion of erythrocytes. Parasitemia increased exponentially after infection with Plasmodium berghei NK65, P. chabaudi, and P. vinckei in Duffy antigen knockout, glycophorin A knockout, and wild-type mice, indicating that the Duffy antigen and glycophorin A are not essential for these malaria parasites. However, parasitemia of the Duffy antigen knockout mice infected with P. yoelii 17XL remained constant from day 5 to 14 after infection, and then decreased, resulting in autotherapy. The treatment of P. yoelii 17XL-infected Duffy antigen knockout mice with anti-CD4 antibody increased the parasitemia 15 days after infection and the mice eventually died, indicating that CD-4-positive cells play an important role in the clearance of P. yoelii 17XL at the late stage of the infection.

Original languageEnglish
Pages (from-to)499-503
Number of pages5
JournalParasitology Research
Volume93
Issue number6
DOIs
Publication statusPublished - Aug 2004

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ASJC Scopus subject areas

  • Parasitology

Cite this

Akimitsu, N., Kim, H-S., Hamamoto, H., Kamura, K., Fukuma, N., Arimitsu, N., Ono, K., Wataya, Y., Torii, M., & Sekimizu, K. (2004). Duffy antigen is important for the lethal effect of the lethal strain of Plasmodium yoelii 17XL. Parasitology Research, 93(6), 499-503. https://doi.org/10.1007/s00436-004-1165-x