Dual-time-point F-18 FDG PET/CT for evaluation in patients with malignant lymphoma

Takayoshi Shinya, Soichiro Fujii, Shoji Asakura, Toshitaka Taniguchi, Kotaro Yoshio, Aierken Alafate, Shuhei Sato, Tadashi Yoshino, Susumu Kanazawa

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objective The aim of this study was to evaluate the usefulness of F-18 fluorodeoxyglucose (FDG) dual-timepoint (DTP) positron emission tomography (PET)/computed tomography (CT) with semiquantitative analyses for the initial staging in patients with malignant lymphoma. Methods Forty-three patients had DTP PET/CT, with 60-min and 2-h scan [n = 8, Hodgkin's lymphoma (HL); n = 12, indolent non-Hodgkin lymphoma (NHL); n = 23, aggressive NHL]. Results A total of 524 lesions were evaluated (406 lymph nodes and 118 extra-nodal lesions). The maximum standardized uptake value (SUVmax) on 2-h delayed scan (SUV2) was significantly higher than those on 1-h early scan (SUV1) for all groups (P1 and SUV2 (each P1 and SUV2 (P = 0.6891 for SUV1; P = 0.8828 for SUV 2); however, significant differences were detected for the retention index of SUVmax between these groups (P = 0.0238). Conclusions DTP F-18 FDG PET/CT with a semiquantitative technique may have the potential to provide the more accurate diagnoses for the staging of malignant lymphoma and the more important role in predicting the histological grades of malignancy compared with singletime- point F-18 FDG-PET scan.

Original languageEnglish
Pages (from-to)616-621
Number of pages6
JournalAnnals of Nuclear Medicine
Volume26
Issue number8
DOIs
Publication statusPublished - Oct 2012

Fingerprint

Fluorodeoxyglucose F18
Lymphoma
Non-Hodgkin's Lymphoma
Hodgkin Disease
Positron-Emission Tomography
Lymph Nodes
Positron Emission Tomography Computed Tomography
Neoplasms

Keywords

  • Delayed scan
  • Dual-time-point (DTP)
  • F-18 FDG
  • Malignant lymphoma
  • PET/CT

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Dual-time-point F-18 FDG PET/CT for evaluation in patients with malignant lymphoma. / Shinya, Takayoshi; Fujii, Soichiro; Asakura, Shoji; Taniguchi, Toshitaka; Yoshio, Kotaro; Alafate, Aierken; Sato, Shuhei; Yoshino, Tadashi; Kanazawa, Susumu.

In: Annals of Nuclear Medicine, Vol. 26, No. 8, 10.2012, p. 616-621.

Research output: Contribution to journalArticle

Shinya, Takayoshi ; Fujii, Soichiro ; Asakura, Shoji ; Taniguchi, Toshitaka ; Yoshio, Kotaro ; Alafate, Aierken ; Sato, Shuhei ; Yoshino, Tadashi ; Kanazawa, Susumu. / Dual-time-point F-18 FDG PET/CT for evaluation in patients with malignant lymphoma. In: Annals of Nuclear Medicine. 2012 ; Vol. 26, No. 8. pp. 616-621.
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