Bone mineral density (BMD) of the lumbar spine was measured by dual energy X-ray absorptiometry (DXA) in nine Japanese children with growth hormone (GH) deficiency. Before hGH therapy, BMDs of the GH-deficient patients were lower than those of controls. When their bone ages were substituted for their chronological ages, however, almost all BMDs of the patients were distributed within the normal range. After 12 months of hGH therapy, the BMDs increased in 8 of 9 GH-deficient patients; they were still lower as compared to controls. the relation between BMDs and bone ages suggested delayed skeletal maturation in GH-deficient patients. dual energy X-ray absorptiometry (DXA), growth hormone deficiency, bone mineral density (BMD), lumbar vertebrae, Japanese children.
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Endocrinology, Diabetes and Metabolism