Drug-Repositioning Approaches Based on Medical and Life Science Databases

Yoshito Zamami, Hirofumi Hamano, Takahiro Niimura, Fuka Aizawa, Kenta Yagi, Mitsuhiro Goda, Yuki Izawa-Ishizawa, Keisuke Ishizawa

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

Drug repositioning is a drug discovery strategy in which an existing drug is utilized as a therapeutic agent for a different disease. As information regarding the safety, pharmacokinetics, and formulation of existing drugs is already available, the cost and time required for drug development is reduced. Conventional drug repositioning has been dominated by a method involving the search for candidate drugs that act on the target molecules of an organism in a diseased state through basic research. However, recently, information hosted on medical information and life science databases have been used in translational research to bridge the gap between basic research in drug repositioning and clinical application. Here, we review an example of drug repositioning wherein candidate drugs were found and their mechanisms of action against a novel therapeutic target were identified via a basic research method that combines the findings retrieved from various medical and life science databases.

Original languageEnglish
Article number752174
JournalFrontiers in Pharmacology
Volume12
DOIs
Publication statusPublished - Nov 1 2021
Externally publishedYes

Keywords

  • database
  • drug repositioning
  • existing drugs
  • life science databases
  • medical information database

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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