Drosophila type XV/XVIII collagen, Mp, is involved in Wingless distribution

Ryusuke Momota, Ichiro Naito, Yoshifumi Ninomiya, Aiji Ohtsuka

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Multiplexin (Mp) is the Drosophila orthologue of vertebrate collagens XV and XVIII. Like them, Mp is widely distributed in the basement membranes of the developing embryos, including those of neuroblasts in the central and peripheral nervous systems, visceral muscles of the gut, and contractile cardioblasts. Here we report the identification of mutant larvae bearing piggyBac transposon insertions that exhibit decrease Mp production associated with abdominal cuticular and wing margin defects, malformation of sensory organs and impaired sensitivity to physical stimuli. Additional findings include the abnormal ultrastructure of fatbody associated with abnormal collagen IV deposition, and reduced Wingless deposition. Collectively, these findings are consistent with the notion that Mp is required for the proper formation and/or maintenance of basement membrane, and that Mp may be involved in establishing the Wingless signaling gradients in the Drosophila embryo.

Original languageEnglish
Pages (from-to)258-266
Number of pages9
JournalMatrix Biology
Volume30
Issue number4
DOIs
Publication statusPublished - May 2011

Fingerprint

Collagen Type XVIII
Basement Membrane
Drosophila
Embryonic Structures
Peripheral Nervous System
Larva
Vertebrates
Collagen
Central Nervous System
Maintenance
Muscles

Keywords

  • Basement membrane
  • Chondroitin sulfate
  • Collagen
  • Extracellular matrix
  • Proteoglycan
  • Wingless/Wnt

ASJC Scopus subject areas

  • Molecular Biology

Cite this

Drosophila type XV/XVIII collagen, Mp, is involved in Wingless distribution. / Momota, Ryusuke; Naito, Ichiro; Ninomiya, Yoshifumi; Ohtsuka, Aiji.

In: Matrix Biology, Vol. 30, No. 4, 05.2011, p. 258-266.

Research output: Contribution to journalArticle

Momota, Ryusuke ; Naito, Ichiro ; Ninomiya, Yoshifumi ; Ohtsuka, Aiji. / Drosophila type XV/XVIII collagen, Mp, is involved in Wingless distribution. In: Matrix Biology. 2011 ; Vol. 30, No. 4. pp. 258-266.
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