Drill needle aspiration biopsy for submucosal tumors in an experimental study

Masaya Uesato, Tomohide Tamachi, Naoyuki Hanari, Yorihiko Muto, Akiko Kagaya, Ryuma Urahama, Yukiko Ogura, Hiroshi Suito, Akira Nakano, Mizuho Aikawa, Takashi Oide, Hisahiro Matsubara

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1 Citation (Scopus)

Abstract

Background and aims: EUS-guided FNA biopsy has been widely performed to aid in the diagnosis of submucosal tumors (SMTs). However, in cases of small tumors, the diagnostic yield of EUS-FNA is poor. Therefore, it is necessary to develop a new needle for the diagnosis. We developed a device with a new mechanism that we refer to as a drill needle aspiration biopsy (DNAB). The aim of this study was to evaluate the use of DNAB in resected gastric SMT specimens. Methods: A drill needle with a sharp tip and wide ditch was inserted into a catheter for angiography. Continuous suction is enabled through the catheter at the tip. DNAB was performed with one pass and one stroke in 13 gastric SMTs resected by operation. Similarly, FNA was performed by one pass and ten strokes. These gastric tumors included nine diagnosed gastrointestinal stromal tumors and four undiagnosed SMTs by preoperative examinations. The tissue quantity between DNAB and FNA was macroscopically and microscopically examined. Results: All 13 drill biopsy specimens were obtained. Additionally, all 13 gastric SMTs, including 4 undiagnosed tumors, could be diagnosed by DNAB. The quantity of each specimen obtained by DNAB was macroscopically and microscopically much greater than that by FNA. In particular, for tumors <25 mm in the longer axis, the ratio of microscopic diagnosable cases was 100 % (7/7) for DNAB and 42.9 % (3/7) for FNA. Conclusions: DNAB is a novel method that can obtain more tissue than FNA for small gastric SMT.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalGastric Cancer
DOIs
Publication statusAccepted/In press - Aug 16 2016
Externally publishedYes

Keywords

  • Aspiration
  • Drill needle
  • FNA
  • GIST
  • SMT

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology
  • Cancer Research

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  • Cite this

    Uesato, M., Tamachi, T., Hanari, N., Muto, Y., Kagaya, A., Urahama, R., Ogura, Y., Suito, H., Nakano, A., Aikawa, M., Oide, T., & Matsubara, H. (Accepted/In press). Drill needle aspiration biopsy for submucosal tumors in an experimental study. Gastric Cancer, 1-6. https://doi.org/10.1007/s10120-016-0630-4