Downregulation of the β1,3-galactosyltransferase gene in tonsillar B lymphocytes and aberrant lectin bindings to tonsillar IgA as a pathogenesis of IgA nephropathy

Tatsuyuki Inoue, Hitoshi Sugiyama, Yoko Kikumoto, Naomi Fukuoka, Yohei Maeshima, Hisashi Hattori, Kunihiro Fukushima, Kazunori Nishizaki, Yoshiyuki Hiki, Hirofumi Makino

Research output: Chapter in Book/Report/Conference proceedingConference contribution

12 Citations (Scopus)

Abstract

IgA is a glycoprotein with multiple O-glycans. Under-O-glycosylation of the hinge in IgA in patients with IgA nephropathy (IgAN) is reported. The development of IgAN is frequently preceded by episodes of upper respiratory tract infections such as tonsillitis. Therefore, the tonsils may be related to the pathogenesis of IgAN. However, the mechanism of underglycosylation in tonsillar IgA has not yet been fully elucidated. Since O-glycans in IgA are produced by glycosyltransferases, we hypothesized that dysregulation of the enzymes is associated with underglycosylation.

Original languageEnglish
Title of host publicationIgA Nephropathy Today
EditorsYasuhiko Tomino
Pages120-124
Number of pages5
DOIs
Publication statusPublished - 2007

Publication series

NameContributions to Nephrology
Volume157
ISSN (Print)0302-5144

ASJC Scopus subject areas

  • Nephrology

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    Inoue, T., Sugiyama, H., Kikumoto, Y., Fukuoka, N., Maeshima, Y., Hattori, H., Fukushima, K., Nishizaki, K., Hiki, Y., & Makino, H. (2007). Downregulation of the β1,3-galactosyltransferase gene in tonsillar B lymphocytes and aberrant lectin bindings to tonsillar IgA as a pathogenesis of IgA nephropathy. In Y. Tomino (Ed.), IgA Nephropathy Today (pp. 120-124). (Contributions to Nephrology; Vol. 157). https://doi.org/10.1159/0000102315