Downregulation of the β1,3-galactosyltransferase gene in tonsillar B lymphocytes and aberrant lectin bindings to tonsillar IgA as a pathogenesis of IgA nephropathy

Tatsuyuki Inoue; Hitoshi Sugiyama; Yoko Kikumoto; Naomi Fukuoka; Yohei Maeshima; Hisashi Hattori; Kunihiro Fukushima; Kazunori Nishizaki; Yoshiyuki Hiki; Hirofumi Makino

doi:10.1159/0000102315

Downregulation of the β1,3-galactosyltransferase gene in tonsillar B lymphocytes and aberrant lectin bindings to tonsillar IgA as a pathogenesis of IgA nephropathy

Tatsuyuki Inoue, Hitoshi Sugiyama, Yoko Kikumoto, Naomi Fukuoka, Yohei Maeshima, Hisashi Hattori, Kunihiro Fukushima, Kazunori Nishizaki, Yoshiyuki Hiki, Hirofumi Makino

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

14 Citations (Scopus)

Abstract

IgA is a glycoprotein with multiple O-glycans. Under-O-glycosylation of the hinge in IgA in patients with IgA nephropathy (IgAN) is reported. The development of IgAN is frequently preceded by episodes of upper respiratory tract infections such as tonsillitis. Therefore, the tonsils may be related to the pathogenesis of IgAN. However, the mechanism of underglycosylation in tonsillar IgA has not yet been fully elucidated. Since O-glycans in IgA are produced by glycosyltransferases, we hypothesized that dysregulation of the enzymes is associated with underglycosylation.

Original language	English
Title of host publication	IgA Nephropathy Today
Editors	Yasuhiko Tomino
Pages	120-124
Number of pages	5
DOIs	https://doi.org/10.1159/0000102315
Publication status	Published - 2007

Publication series

Name	Contributions to Nephrology
Volume	157
ISSN (Print)	0302-5144

ASJC Scopus subject areas

Nephrology

Access to Document

10.1159/0000102315

Cite this

Inoue, T., Sugiyama, H., Kikumoto, Y., Fukuoka, N., Maeshima, Y., Hattori, H., Fukushima, K., Nishizaki, K., Hiki, Y., & Makino, H. (2007). Downregulation of the β1,3-galactosyltransferase gene in tonsillar B lymphocytes and aberrant lectin bindings to tonsillar IgA as a pathogenesis of IgA nephropathy. In Y. Tomino (Ed.), IgA Nephropathy Today (pp. 120-124). (Contributions to Nephrology; Vol. 157). https://doi.org/10.1159/0000102315

Downregulation of the β1,3-galactosyltransferase gene in tonsillar B lymphocytes and aberrant lectin bindings to tonsillar IgA as a pathogenesis of IgA nephropathy. / Inoue, Tatsuyuki; Sugiyama, Hitoshi; Kikumoto, Yoko et al.

IgA Nephropathy Today. ed. / Yasuhiko Tomino. 2007. p. 120-124 (Contributions to Nephrology; Vol. 157).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Inoue, T, Sugiyama, H, Kikumoto, Y, Fukuoka, N, Maeshima, Y, Hattori, H, Fukushima, K, Nishizaki, K, Hiki, Y & Makino, H 2007, Downregulation of the β1,3-galactosyltransferase gene in tonsillar B lymphocytes and aberrant lectin bindings to tonsillar IgA as a pathogenesis of IgA nephropathy. in Y Tomino (ed.), IgA Nephropathy Today. Contributions to Nephrology, vol. 157, pp. 120-124. https://doi.org/10.1159/0000102315

@inproceedings{2d04ad4b17fb4aa68e4da499dedf4935,

title = "Downregulation of the β1,3-galactosyltransferase gene in tonsillar B lymphocytes and aberrant lectin bindings to tonsillar IgA as a pathogenesis of IgA nephropathy",

abstract = "IgA is a glycoprotein with multiple O-glycans. Under-O-glycosylation of the hinge in IgA in patients with IgA nephropathy (IgAN) is reported. The development of IgAN is frequently preceded by episodes of upper respiratory tract infections such as tonsillitis. Therefore, the tonsils may be related to the pathogenesis of IgAN. However, the mechanism of underglycosylation in tonsillar IgA has not yet been fully elucidated. Since O-glycans in IgA are produced by glycosyltransferases, we hypothesized that dysregulation of the enzymes is associated with underglycosylation.",

author = "Tatsuyuki Inoue and Hitoshi Sugiyama and Yoko Kikumoto and Naomi Fukuoka and Yohei Maeshima and Hisashi Hattori and Kunihiro Fukushima and Kazunori Nishizaki and Yoshiyuki Hiki and Hirofumi Makino",

year = "2007",

doi = "10.1159/0000102315",

language = "English",

isbn = "3805582862",

series = "Contributions to Nephrology",

pages = "120--124",

editor = "Yasuhiko Tomino",

booktitle = "IgA Nephropathy Today",

}

TY - GEN

T1 - Downregulation of the β1,3-galactosyltransferase gene in tonsillar B lymphocytes and aberrant lectin bindings to tonsillar IgA as a pathogenesis of IgA nephropathy

AU - Inoue, Tatsuyuki

AU - Sugiyama, Hitoshi

AU - Kikumoto, Yoko

AU - Fukuoka, Naomi

AU - Maeshima, Yohei

AU - Hattori, Hisashi

AU - Fukushima, Kunihiro

AU - Nishizaki, Kazunori

AU - Hiki, Yoshiyuki

AU - Makino, Hirofumi

PY - 2007

Y1 - 2007

N2 - IgA is a glycoprotein with multiple O-glycans. Under-O-glycosylation of the hinge in IgA in patients with IgA nephropathy (IgAN) is reported. The development of IgAN is frequently preceded by episodes of upper respiratory tract infections such as tonsillitis. Therefore, the tonsils may be related to the pathogenesis of IgAN. However, the mechanism of underglycosylation in tonsillar IgA has not yet been fully elucidated. Since O-glycans in IgA are produced by glycosyltransferases, we hypothesized that dysregulation of the enzymes is associated with underglycosylation.

AB - IgA is a glycoprotein with multiple O-glycans. Under-O-glycosylation of the hinge in IgA in patients with IgA nephropathy (IgAN) is reported. The development of IgAN is frequently preceded by episodes of upper respiratory tract infections such as tonsillitis. Therefore, the tonsils may be related to the pathogenesis of IgAN. However, the mechanism of underglycosylation in tonsillar IgA has not yet been fully elucidated. Since O-glycans in IgA are produced by glycosyltransferases, we hypothesized that dysregulation of the enzymes is associated with underglycosylation.

UR - http://www.scopus.com/inward/record.url?scp=34249048273&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34249048273&partnerID=8YFLogxK

U2 - 10.1159/0000102315

DO - 10.1159/0000102315

M3 - Conference contribution

C2 - 17495448

AN - SCOPUS:34249048273

SN - 3805582862

SN - 9783805582865

T3 - Contributions to Nephrology

SP - 120

EP - 124

BT - IgA Nephropathy Today

A2 - Tomino, Yasuhiko

ER -

Downregulation of the β1,3-galactosyltransferase gene in tonsillar B lymphocytes and aberrant lectin bindings to tonsillar IgA as a pathogenesis of IgA nephropathy

Abstract

Publication series

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this