Down-regulation of ASY/Nogo transcription associated with progression of adult T-cell leukemia/lymphoma

Misuzu Shimakage, Nobumasa Inoue, Kohichi Ohshima, Kunimitsu Kawahara, Takashi Oka, Kazuta Yasui, Kayoko Matsumoto, Hirokazu Inoue, Akihiro Watari, Shinji Higashiyama, Masuo Yutsudo

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13 Citations (Scopus)

Abstract

Adult T-cell leukemia/lymphoma (ATLL) is an aggressive form of human leukemia/lymphoma. Although this disease is initiated by infection with human T-lymphotropic virus type 1 (HTLV-1), many HTLV-1 carriers survive for a long period without aggressive illness, suggesting that other factors may play roles in the progression of ATLL to an aggressive state. However, the mechanism involved in this progression still remains unclear. Previously, we have reported that ASY/Nogo mRNA was markedly down-regulated in human small-cell lung carcinomas, whereas it was expressed in normal tissues and other lung carcinomas, such as adenocarcinoma and squamous cell carcinoma. To understand whether or not ASY/Nogo gene is involved in the progression of ATLL, we examined the expression of ASY/Nogo mRNA in smoldering, chronic and aggressive ATLL, and found that the expression level of ASY/Nogo mRNA was markedly reduced in clinically aggressive ATLL. HTLV-1 Tax expression was not affected by the down-regulation of ASY/Nogo mRNA. These results indicate that the ASY/Nogo gene may act as a suppressor against ATLL progression, independent of Tax expression.

Original languageEnglish
Pages (from-to)1648-1653
Number of pages6
JournalInternational Journal of Cancer
Volume119
Issue number7
DOIs
Publication statusPublished - Oct 1 2006

Keywords

  • ASY/Nogo
  • ATLL
  • Progression
  • Tax
  • mRNA in situ hybridization

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Shimakage, M., Inoue, N., Ohshima, K., Kawahara, K., Oka, T., Yasui, K., Matsumoto, K., Inoue, H., Watari, A., Higashiyama, S., & Yutsudo, M. (2006). Down-regulation of ASY/Nogo transcription associated with progression of adult T-cell leukemia/lymphoma. International Journal of Cancer, 119(7), 1648-1653. https://doi.org/10.1002/ijc.22011