Abstract
Adult T-cell leukemia/lymphoma (ATLL) is an aggressive form of human leukemia/lymphoma. Although this disease is initiated by infection with human T-lymphotropic virus type 1 (HTLV-1), many HTLV-1 carriers survive for a long period without aggressive illness, suggesting that other factors may play roles in the progression of ATLL to an aggressive state. However, the mechanism involved in this progression still remains unclear. Previously, we have reported that ASY/Nogo mRNA was markedly down-regulated in human small-cell lung carcinomas, whereas it was expressed in normal tissues and other lung carcinomas, such as adenocarcinoma and squamous cell carcinoma. To understand whether or not ASY/Nogo gene is involved in the progression of ATLL, we examined the expression of ASY/Nogo mRNA in smoldering, chronic and aggressive ATLL, and found that the expression level of ASY/Nogo mRNA was markedly reduced in clinically aggressive ATLL. HTLV-1 Tax expression was not affected by the down-regulation of ASY/Nogo mRNA. These results indicate that the ASY/Nogo gene may act as a suppressor against ATLL progression, independent of Tax expression.
| Original language | English |
|---|---|
| Pages (from-to) | 1648-1653 |
| Number of pages | 6 |
| Journal | International Journal of Cancer |
| Volume | 119 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Oct 1 2006 |
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Keywords
- ASY/Nogo
- ATLL
- mRNA in situ hybridization
- Progression
- Tax
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Down-regulation of ASY/Nogo transcription associated with progression of adult T-cell leukemia/lymphoma. / Shimakage, Misuzu; Inoue, Nobumasa; Ohshima, Kohichi; Kawahara, Kunimitsu; Oka, Takashi; Yasui, Kazuta; Matsumoto, Kayoko; Inoue, Hirokazu; Watari, Akihiro; Higashiyama, Shinji; Yutsudo, Masuo.
In: International Journal of Cancer, Vol. 119, No. 7, 01.10.2006, p. 1648-1653.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Down-regulation of ASY/Nogo transcription associated with progression of adult T-cell leukemia/lymphoma
AU - Shimakage, Misuzu
AU - Inoue, Nobumasa
AU - Ohshima, Kohichi
AU - Kawahara, Kunimitsu
AU - Oka, Takashi
AU - Yasui, Kazuta
AU - Matsumoto, Kayoko
AU - Inoue, Hirokazu
AU - Watari, Akihiro
AU - Higashiyama, Shinji
AU - Yutsudo, Masuo
PY - 2006/10/1
Y1 - 2006/10/1
N2 - Adult T-cell leukemia/lymphoma (ATLL) is an aggressive form of human leukemia/lymphoma. Although this disease is initiated by infection with human T-lymphotropic virus type 1 (HTLV-1), many HTLV-1 carriers survive for a long period without aggressive illness, suggesting that other factors may play roles in the progression of ATLL to an aggressive state. However, the mechanism involved in this progression still remains unclear. Previously, we have reported that ASY/Nogo mRNA was markedly down-regulated in human small-cell lung carcinomas, whereas it was expressed in normal tissues and other lung carcinomas, such as adenocarcinoma and squamous cell carcinoma. To understand whether or not ASY/Nogo gene is involved in the progression of ATLL, we examined the expression of ASY/Nogo mRNA in smoldering, chronic and aggressive ATLL, and found that the expression level of ASY/Nogo mRNA was markedly reduced in clinically aggressive ATLL. HTLV-1 Tax expression was not affected by the down-regulation of ASY/Nogo mRNA. These results indicate that the ASY/Nogo gene may act as a suppressor against ATLL progression, independent of Tax expression.
AB - Adult T-cell leukemia/lymphoma (ATLL) is an aggressive form of human leukemia/lymphoma. Although this disease is initiated by infection with human T-lymphotropic virus type 1 (HTLV-1), many HTLV-1 carriers survive for a long period without aggressive illness, suggesting that other factors may play roles in the progression of ATLL to an aggressive state. However, the mechanism involved in this progression still remains unclear. Previously, we have reported that ASY/Nogo mRNA was markedly down-regulated in human small-cell lung carcinomas, whereas it was expressed in normal tissues and other lung carcinomas, such as adenocarcinoma and squamous cell carcinoma. To understand whether or not ASY/Nogo gene is involved in the progression of ATLL, we examined the expression of ASY/Nogo mRNA in smoldering, chronic and aggressive ATLL, and found that the expression level of ASY/Nogo mRNA was markedly reduced in clinically aggressive ATLL. HTLV-1 Tax expression was not affected by the down-regulation of ASY/Nogo mRNA. These results indicate that the ASY/Nogo gene may act as a suppressor against ATLL progression, independent of Tax expression.
KW - ASY/Nogo
KW - ATLL
KW - mRNA in situ hybridization
KW - Progression
KW - Tax
UR - http://www.scopus.com/inward/record.url?scp=33747470604&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33747470604&partnerID=8YFLogxK
U2 - 10.1002/ijc.22011
DO - 10.1002/ijc.22011
M3 - Article
VL - 119
SP - 1648
EP - 1653
JO - International Journal of Cancer
JF - International Journal of Cancer
SN - 0020-7136
IS - 7
ER -