Double primary lung cancers producing alpha-fetoprotein

T. Bessho, S. Miyoshi, S. Maebeya, T. Suzuma, I. Hirai, Y. Naito

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A 81-year-old male with a high serum alpha-fetoprotein (AFP) level of 2644 ng/ml underwent left pneumonectomy for squamous cell carcinoma in the lower lobe and large cell carcinoma in the upper lobe. Both tumors were classified as pathological T2N0M0 and stage I. The AFP level was normalized to be 19 ng/ml in 49th postoperative day. Immunohistochemical staining using anti-AFP antibody demonstrated AFP granules only in the large cell carcinoma. The study of lectin affinity against the serum AFP revealed that the concanavalin A (Con-A) non-reactive fraction rate was 14%, the lentil agglutinin (LCA) non-reactive and strongly reactive subfractions were 16.7 and 83%, respectively and P2, P4 and P5 subfractions of the erythroaggultinating phytohemagglutinin (E-PHA) were 58.6, 24.9 and 16.5%, respectively. According to the analysis of 21 cases reported in the Japanese literature including our case, the AFP did not demonstrate a common affinity pattern against the Con-A but the common pattern resembling hepatocellular carcinoma against LCA and E-PHA.

Original languageEnglish
Pages (from-to)2216-2220
Number of pages5
JournalJournal of the Japanese Association for Thoracic Surgery
Volume44
Issue number12
Publication statusPublished - Dec 1996
Externally publishedYes

Fingerprint

alpha-Fetoproteins
Lung Neoplasms
Large Cell Carcinoma
Phytohemagglutinins
Concanavalin A
Pneumonectomy
Serum
Lectins
Hepatocellular Carcinoma
Squamous Cell Carcinoma
Staining and Labeling
Antibodies
Neoplasms

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Bessho, T., Miyoshi, S., Maebeya, S., Suzuma, T., Hirai, I., & Naito, Y. (1996). Double primary lung cancers producing alpha-fetoprotein. Journal of the Japanese Association for Thoracic Surgery, 44(12), 2216-2220.

Double primary lung cancers producing alpha-fetoprotein. / Bessho, T.; Miyoshi, S.; Maebeya, S.; Suzuma, T.; Hirai, I.; Naito, Y.

In: Journal of the Japanese Association for Thoracic Surgery, Vol. 44, No. 12, 12.1996, p. 2216-2220.

Research output: Contribution to journalArticle

Bessho, T, Miyoshi, S, Maebeya, S, Suzuma, T, Hirai, I & Naito, Y 1996, 'Double primary lung cancers producing alpha-fetoprotein', Journal of the Japanese Association for Thoracic Surgery, vol. 44, no. 12, pp. 2216-2220.
Bessho T, Miyoshi S, Maebeya S, Suzuma T, Hirai I, Naito Y. Double primary lung cancers producing alpha-fetoprotein. Journal of the Japanese Association for Thoracic Surgery. 1996 Dec;44(12):2216-2220.
Bessho, T. ; Miyoshi, S. ; Maebeya, S. ; Suzuma, T. ; Hirai, I. ; Naito, Y. / Double primary lung cancers producing alpha-fetoprotein. In: Journal of the Japanese Association for Thoracic Surgery. 1996 ; Vol. 44, No. 12. pp. 2216-2220.
@article{2d908d1178044a15a5157a95189355d2,
title = "Double primary lung cancers producing alpha-fetoprotein",
abstract = "A 81-year-old male with a high serum alpha-fetoprotein (AFP) level of 2644 ng/ml underwent left pneumonectomy for squamous cell carcinoma in the lower lobe and large cell carcinoma in the upper lobe. Both tumors were classified as pathological T2N0M0 and stage I. The AFP level was normalized to be 19 ng/ml in 49th postoperative day. Immunohistochemical staining using anti-AFP antibody demonstrated AFP granules only in the large cell carcinoma. The study of lectin affinity against the serum AFP revealed that the concanavalin A (Con-A) non-reactive fraction rate was 14{\%}, the lentil agglutinin (LCA) non-reactive and strongly reactive subfractions were 16.7 and 83{\%}, respectively and P2, P4 and P5 subfractions of the erythroaggultinating phytohemagglutinin (E-PHA) were 58.6, 24.9 and 16.5{\%}, respectively. According to the analysis of 21 cases reported in the Japanese literature including our case, the AFP did not demonstrate a common affinity pattern against the Con-A but the common pattern resembling hepatocellular carcinoma against LCA and E-PHA.",
author = "T. Bessho and S. Miyoshi and S. Maebeya and T. Suzuma and I. Hirai and Y. Naito",
year = "1996",
month = "12",
language = "English",
volume = "44",
pages = "2216--2220",
journal = "General Thoracic and Cardiovascular Surgery",
issn = "1863-6705",
publisher = "Springer Japan",
number = "12",

}

TY - JOUR

T1 - Double primary lung cancers producing alpha-fetoprotein

AU - Bessho, T.

AU - Miyoshi, S.

AU - Maebeya, S.

AU - Suzuma, T.

AU - Hirai, I.

AU - Naito, Y.

PY - 1996/12

Y1 - 1996/12

N2 - A 81-year-old male with a high serum alpha-fetoprotein (AFP) level of 2644 ng/ml underwent left pneumonectomy for squamous cell carcinoma in the lower lobe and large cell carcinoma in the upper lobe. Both tumors were classified as pathological T2N0M0 and stage I. The AFP level was normalized to be 19 ng/ml in 49th postoperative day. Immunohistochemical staining using anti-AFP antibody demonstrated AFP granules only in the large cell carcinoma. The study of lectin affinity against the serum AFP revealed that the concanavalin A (Con-A) non-reactive fraction rate was 14%, the lentil agglutinin (LCA) non-reactive and strongly reactive subfractions were 16.7 and 83%, respectively and P2, P4 and P5 subfractions of the erythroaggultinating phytohemagglutinin (E-PHA) were 58.6, 24.9 and 16.5%, respectively. According to the analysis of 21 cases reported in the Japanese literature including our case, the AFP did not demonstrate a common affinity pattern against the Con-A but the common pattern resembling hepatocellular carcinoma against LCA and E-PHA.

AB - A 81-year-old male with a high serum alpha-fetoprotein (AFP) level of 2644 ng/ml underwent left pneumonectomy for squamous cell carcinoma in the lower lobe and large cell carcinoma in the upper lobe. Both tumors were classified as pathological T2N0M0 and stage I. The AFP level was normalized to be 19 ng/ml in 49th postoperative day. Immunohistochemical staining using anti-AFP antibody demonstrated AFP granules only in the large cell carcinoma. The study of lectin affinity against the serum AFP revealed that the concanavalin A (Con-A) non-reactive fraction rate was 14%, the lentil agglutinin (LCA) non-reactive and strongly reactive subfractions were 16.7 and 83%, respectively and P2, P4 and P5 subfractions of the erythroaggultinating phytohemagglutinin (E-PHA) were 58.6, 24.9 and 16.5%, respectively. According to the analysis of 21 cases reported in the Japanese literature including our case, the AFP did not demonstrate a common affinity pattern against the Con-A but the common pattern resembling hepatocellular carcinoma against LCA and E-PHA.

UR - http://www.scopus.com/inward/record.url?scp=0030345246&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030345246&partnerID=8YFLogxK

M3 - Article

C2 - 8990900

AN - SCOPUS:0030345246

VL - 44

SP - 2216

EP - 2220

JO - General Thoracic and Cardiovascular Surgery

JF - General Thoracic and Cardiovascular Surgery

SN - 1863-6705

IS - 12

ER -