Abstract
We report a 62-year-old male with extensive disease small-cell lung cancer (SCLC) who was successfully treated with double high-dose chemotherapy supported by autologous peripheral blood stem cell transplantation (auto- PBSCT). This patient achieved a partial response with 3 cycles of induction chemotherapy. After the peripheral blood stem cell mobilization, two cycles of high-dose ICE regimen (ifosfamide 3,000 mg/m2 at days 1 to 5, carboplatin 400 mg/m2 at days 1, 3, 5, and etoposide 500 mg/m2 at days 1, 3, 5) could be given with further regression of the tumor and acceptable toxicities. This successful case suggests the feasibility of double high-dose ICE with auto- PBSCT in elderly patients with SCLC.
| Original language | English |
|---|---|
| Pages (from-to) | 892-895 |
| Number of pages | 4 |
| Journal | Internal Medicine |
| Volume | 38 |
| Issue number | 11 |
| Publication status | Published - 1999 |
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Keywords
- Autologous peripheral blood stem cell transplantation (auto-PBSCT)
- Double transplantation
ASJC Scopus subject areas
- Internal Medicine
Cite this
Double high-dose chemotherapy supported by autologous transplantation of peripheral blood stem cells for treatment of an elderly patient with small- cell lung cancer. / Yamane, H.; Bessho, A.; Kiura, Katsuyuki; Tabata, Masahiro; Katayama, Y.; Motoda, K.; Tsuchida, T.; Nogami, N.; Hiraki, A.; Ueoka, H.; Harada, M.
In: Internal Medicine, Vol. 38, No. 11, 1999, p. 892-895.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Double high-dose chemotherapy supported by autologous transplantation of peripheral blood stem cells for treatment of an elderly patient with small- cell lung cancer
AU - Yamane, H.
AU - Bessho, A.
AU - Kiura, Katsuyuki
AU - Tabata, Masahiro
AU - Katayama, Y.
AU - Motoda, K.
AU - Tsuchida, T.
AU - Nogami, N.
AU - Hiraki, A.
AU - Ueoka, H.
AU - Harada, M.
PY - 1999
Y1 - 1999
N2 - We report a 62-year-old male with extensive disease small-cell lung cancer (SCLC) who was successfully treated with double high-dose chemotherapy supported by autologous peripheral blood stem cell transplantation (auto- PBSCT). This patient achieved a partial response with 3 cycles of induction chemotherapy. After the peripheral blood stem cell mobilization, two cycles of high-dose ICE regimen (ifosfamide 3,000 mg/m2 at days 1 to 5, carboplatin 400 mg/m2 at days 1, 3, 5, and etoposide 500 mg/m2 at days 1, 3, 5) could be given with further regression of the tumor and acceptable toxicities. This successful case suggests the feasibility of double high-dose ICE with auto- PBSCT in elderly patients with SCLC.
AB - We report a 62-year-old male with extensive disease small-cell lung cancer (SCLC) who was successfully treated with double high-dose chemotherapy supported by autologous peripheral blood stem cell transplantation (auto- PBSCT). This patient achieved a partial response with 3 cycles of induction chemotherapy. After the peripheral blood stem cell mobilization, two cycles of high-dose ICE regimen (ifosfamide 3,000 mg/m2 at days 1 to 5, carboplatin 400 mg/m2 at days 1, 3, 5, and etoposide 500 mg/m2 at days 1, 3, 5) could be given with further regression of the tumor and acceptable toxicities. This successful case suggests the feasibility of double high-dose ICE with auto- PBSCT in elderly patients with SCLC.
KW - Autologous peripheral blood stem cell transplantation (auto-PBSCT)
KW - Double transplantation
UR - http://www.scopus.com/inward/record.url?scp=0032726889&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032726889&partnerID=8YFLogxK
M3 - Article
C2 - 10563752
AN - SCOPUS:0032726889
VL - 38
SP - 892
EP - 895
JO - Internal Medicine
JF - Internal Medicine
SN - 0918-2918
IS - 11
ER -