Double high-dose chemotherapy supported by autologous transplantation of peripheral blood stem cells for treatment of an elderly patient with small- cell lung cancer

H. Yamane, A. Bessho, Katsuyuki Kiura, Masahiro Tabata, Y. Katayama, K. Motoda, T. Tsuchida, N. Nogami, A. Hiraki, H. Ueoka, M. Harada

Research output: Contribution to journalArticle

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Abstract

We report a 62-year-old male with extensive disease small-cell lung cancer (SCLC) who was successfully treated with double high-dose chemotherapy supported by autologous peripheral blood stem cell transplantation (auto- PBSCT). This patient achieved a partial response with 3 cycles of induction chemotherapy. After the peripheral blood stem cell mobilization, two cycles of high-dose ICE regimen (ifosfamide 3,000 mg/m2 at days 1 to 5, carboplatin 400 mg/m2 at days 1, 3, 5, and etoposide 500 mg/m2 at days 1, 3, 5) could be given with further regression of the tumor and acceptable toxicities. This successful case suggests the feasibility of double high-dose ICE with auto- PBSCT in elderly patients with SCLC.

Original languageEnglish
Pages (from-to)892-895
Number of pages4
JournalInternal Medicine
Volume38
Issue number11
Publication statusPublished - 1999

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Peripheral Blood Stem Cell Transplantation
Autologous Transplantation
Small Cell Lung Carcinoma
Hematopoietic Stem Cell Mobilization
Drug Therapy
Ifosfamide
Induction Chemotherapy
Carboplatin
Etoposide
Therapeutics
Neoplasms
Peripheral Blood Stem Cells
ICE protocol 3

Keywords

  • Autologous peripheral blood stem cell transplantation (auto-PBSCT)
  • Double transplantation

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Double high-dose chemotherapy supported by autologous transplantation of peripheral blood stem cells for treatment of an elderly patient with small- cell lung cancer. / Yamane, H.; Bessho, A.; Kiura, Katsuyuki; Tabata, Masahiro; Katayama, Y.; Motoda, K.; Tsuchida, T.; Nogami, N.; Hiraki, A.; Ueoka, H.; Harada, M.

In: Internal Medicine, Vol. 38, No. 11, 1999, p. 892-895.

Research output: Contribution to journalArticle

Yamane, H, Bessho, A, Kiura, K, Tabata, M, Katayama, Y, Motoda, K, Tsuchida, T, Nogami, N, Hiraki, A, Ueoka, H & Harada, M 1999, 'Double high-dose chemotherapy supported by autologous transplantation of peripheral blood stem cells for treatment of an elderly patient with small- cell lung cancer', Internal Medicine, vol. 38, no. 11, pp. 892-895.
Yamane, H. ; Bessho, A. ; Kiura, Katsuyuki ; Tabata, Masahiro ; Katayama, Y. ; Motoda, K. ; Tsuchida, T. ; Nogami, N. ; Hiraki, A. ; Ueoka, H. ; Harada, M. / Double high-dose chemotherapy supported by autologous transplantation of peripheral blood stem cells for treatment of an elderly patient with small- cell lung cancer. In: Internal Medicine. 1999 ; Vol. 38, No. 11. pp. 892-895.
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AU - Yamane, H.

AU - Bessho, A.

AU - Kiura, Katsuyuki

AU - Tabata, Masahiro

AU - Katayama, Y.

AU - Motoda, K.

AU - Tsuchida, T.

AU - Nogami, N.

AU - Hiraki, A.

AU - Ueoka, H.

AU - Harada, M.

PY - 1999

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