Double high-dose chemotherapy supported by autologous transplantation of peripheral blood stem cells for treatment of an elderly patient with small-cell lung cancer

Hiromichi Yamane; Akihiro Bessho; Katsuyuki Kiura; Masahiro Tabata; Yoshio Katayama; Kinya Motoda; Tadashi Tsuchida; Naoyuki Nogami; Akio Hiraki; Hiroshi Ueoka; Mine Harada

doi:10.2169/internalmedicine.38.892

Double high-dose chemotherapy supported by autologous transplantation of peripheral blood stem cells for treatment of an elderly patient with small-cell lung cancer

Hiromichi Yamane, Akihiro Bessho, Katsuyuki Kiura, Masahiro Tabata, Yoshio Katayama, Kinya Motoda, Tadashi Tsuchida, Naoyuki Nogami, Akio Hiraki, Hiroshi Ueoka, Mine Harada

University Hospital

Research output: Contribution to journal › Article › peer-review

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Abstract

We report a 62-year-old male with extensive disease small-cell lung cancer (SCLC) who was successfully treated with double high-dose chemotherapy supported by autologous peripheral blood stem cell transplantation (auto-PBSCT). This patient achieved a partial response with 3 cycles of induction chemotherapy. After the peripheral blood stem cell mobilization, two cycles of high-dose ICE regimen (ifosfamide 3,000 mg/m² at days 1 to 5, carboplatin 400 mg/m² at days 1,3, 5, and etoposide 500 mg/m² at days 1,3,5) could be given with further regression of the tumor and acceptable toxicities. This successful case suggests the feasibility of double high-dose ICE with auto-PBSCT in elderly patients with SCLC.

Original language	English
Pages (from-to)	892-895
Number of pages	4
Journal	Internal Medicine
Volume	38
Issue number	11
DOIs	https://doi.org/10.2169/internalmedicine.38.892
Publication status	Published - Nov 1999

Keywords

Autologous peripheral blood stem cell transplantation (auto-PBSCT)
Double transplantation

ASJC Scopus subject areas

Internal Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Yamane, H., Bessho, A., Kiura, K., Tabata, M., Katayama, Y., Motoda, K., Tsuchida, T., Nogami, N., Hiraki, A., Ueoka, H., & Harada, M. (1999). Double high-dose chemotherapy supported by autologous transplantation of peripheral blood stem cells for treatment of an elderly patient with small-cell lung cancer. Internal Medicine, 38(11), 892-895. https://doi.org/10.2169/internalmedicine.38.892

Yamane, H, Bessho, A, Kiura, K , Tabata, M, Katayama, Y, Motoda, K, Tsuchida, T, Nogami, N, Hiraki, A, Ueoka, H & Harada, M 1999, 'Double high-dose chemotherapy supported by autologous transplantation of peripheral blood stem cells for treatment of an elderly patient with small-cell lung cancer', Internal Medicine, vol. 38, no. 11, pp. 892-895. https://doi.org/10.2169/internalmedicine.38.892

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abstract = "We report a 62-year-old male with extensive disease small-cell lung cancer (SCLC) who was successfully treated with double high-dose chemotherapy supported by autologous peripheral blood stem cell transplantation (auto-PBSCT). This patient achieved a partial response with 3 cycles of induction chemotherapy. After the peripheral blood stem cell mobilization, two cycles of high-dose ICE regimen (ifosfamide 3,000 mg/m2 at days 1 to 5, carboplatin 400 mg/m2 at days 1,3, 5, and etoposide 500 mg/m2 at days 1,3,5) could be given with further regression of the tumor and acceptable toxicities. This successful case suggests the feasibility of double high-dose ICE with auto-PBSCT in elderly patients with SCLC.",

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AU - Yamane, Hiromichi

AU - Bessho, Akihiro

AU - Kiura, Katsuyuki

AU - Tabata, Masahiro

AU - Katayama, Yoshio

AU - Motoda, Kinya

AU - Tsuchida, Tadashi

AU - Nogami, Naoyuki

AU - Hiraki, Akio

AU - Ueoka, Hiroshi

AU - Harada, Mine

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AB - We report a 62-year-old male with extensive disease small-cell lung cancer (SCLC) who was successfully treated with double high-dose chemotherapy supported by autologous peripheral blood stem cell transplantation (auto-PBSCT). This patient achieved a partial response with 3 cycles of induction chemotherapy. After the peripheral blood stem cell mobilization, two cycles of high-dose ICE regimen (ifosfamide 3,000 mg/m2 at days 1 to 5, carboplatin 400 mg/m2 at days 1,3, 5, and etoposide 500 mg/m2 at days 1,3,5) could be given with further regression of the tumor and acceptable toxicities. This successful case suggests the feasibility of double high-dose ICE with auto-PBSCT in elderly patients with SCLC.

KW - Autologous peripheral blood stem cell transplantation (auto-PBSCT)

KW - Double transplantation

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Double high-dose chemotherapy supported by autologous transplantation of peripheral blood stem cells for treatment of an elderly patient with small-cell lung cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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