TY - JOUR
T1 - Double high-dose chemotherapy supported by autologous transplantation of peripheral blood stem cells for treatment of an elderly patient with small-cell lung cancer
AU - Yamane, Hiromichi
AU - Bessho, Akihiro
AU - Kiura, Katsuyuki
AU - Tabata, Masahiro
AU - Katayama, Yoshio
AU - Motoda, Kinya
AU - Tsuchida, Tadashi
AU - Nogami, Naoyuki
AU - Hiraki, Akio
AU - Ueoka, Hiroshi
AU - Harada, Mine
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1999/11
Y1 - 1999/11
N2 - We report a 62-year-old male with extensive disease small-cell lung cancer (SCLC) who was successfully treated with double high-dose chemotherapy supported by autologous peripheral blood stem cell transplantation (auto-PBSCT). This patient achieved a partial response with 3 cycles of induction chemotherapy. After the peripheral blood stem cell mobilization, two cycles of high-dose ICE regimen (ifosfamide 3,000 mg/m2 at days 1 to 5, carboplatin 400 mg/m2 at days 1,3, 5, and etoposide 500 mg/m2 at days 1,3,5) could be given with further regression of the tumor and acceptable toxicities. This successful case suggests the feasibility of double high-dose ICE with auto-PBSCT in elderly patients with SCLC.
AB - We report a 62-year-old male with extensive disease small-cell lung cancer (SCLC) who was successfully treated with double high-dose chemotherapy supported by autologous peripheral blood stem cell transplantation (auto-PBSCT). This patient achieved a partial response with 3 cycles of induction chemotherapy. After the peripheral blood stem cell mobilization, two cycles of high-dose ICE regimen (ifosfamide 3,000 mg/m2 at days 1 to 5, carboplatin 400 mg/m2 at days 1,3, 5, and etoposide 500 mg/m2 at days 1,3,5) could be given with further regression of the tumor and acceptable toxicities. This successful case suggests the feasibility of double high-dose ICE with auto-PBSCT in elderly patients with SCLC.
KW - Autologous peripheral blood stem cell transplantation (auto-PBSCT)
KW - Double transplantation
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U2 - 10.2169/internalmedicine.38.892
DO - 10.2169/internalmedicine.38.892
M3 - Article
C2 - 10563752
AN - SCOPUS:0032726889
VL - 38
SP - 892
EP - 895
JO - Internal Medicine
JF - Internal Medicine
SN - 0918-2918
IS - 11
ER -