Dose finding studies on flucytosine in patients with fungi in their urine

Satoshi Uno, Tadasu Takenaka, Yoshio Nishitani, Toshihide Hayashi, Kazuhiro Hata, Noriaki Ono, Masaya Tsugawa, Hiromi Kumon, Hiroyuki Ohmori, Katsuichi Nanba, Yoshikatu Kondoh, Teruhisa Ohashi, Shin Irie, Tetuzou Kaneshige, Hiroyuki Kawahara, Hiroyoshi Tanaka, Shouichi Yamamoto, Motoyoshi Takada, Daisuke Yamada, Toshihiko AsaiYasuhiro Katayama, Teruaki Akaeda, Akihiro Mizuno, Noritaka Ishito, Nobuyuki Akazawa, Mikio Kishi, Ryouji Nasu, Naoki Mitsuhata, Shunji Hayata, Yasutomo Nasu, Toshiki Yamamoto, Takafumi Akagi, Masanobu Tanimura, Seiichi Kataoka, Yukitoshi Fujita, Yoshikazu Hirai, Yasuhiro Kanemasa, Yasuichi Saitoh

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In order to determine the optimal dose of flucytosine (5-FC) in the treatment of fungi in the urine, we performed a dose-finding study. The patients were randomly assigned to receive 5-FC 2 g or 3 g (potency) for 7–14 days by the envelope method. Overall clinical efficacy was evaluated based on the criteria of the Japanese U TI Committee, with slight modification. The efficacy rates were 65.5% (19/29) for the 2 g group and 71.4% (15/21) for the 3g group, and the respective mycological eradication rates were 76.7% and 77.3%, with no statistically significant difference. Clinical adverse reactions were observed in 2.6% and 6.5% of the patients, respectively, with no statistically significant difference. Consequently, we believe that the optimal daily dose of flucytosine is 2 g (1 g b.i.d.) in the treatment of fungi in the urine.

Original languageEnglish
Pages (from-to)1263-1272
Number of pages10
JournalCHEMOTHERAPY
Volume40
Issue number10
DOIs
Publication statusPublished - Oct 1992
Externally publishedYes

Keywords

  • flucytosine

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases
  • Pharmacology
  • Drug Discovery
  • Oncology

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  • Cite this

    Uno, S., Takenaka, T., Nishitani, Y., Hayashi, T., Hata, K., Ono, N., Tsugawa, M., Kumon, H., Ohmori, H., Nanba, K., Kondoh, Y., Ohashi, T., Irie, S., Kaneshige, T., Kawahara, H., Tanaka, H., Yamamoto, S., Takada, M., Yamada, D., ... Saitoh, Y. (1992). Dose finding studies on flucytosine in patients with fungi in their urine. CHEMOTHERAPY, 40(10), 1263-1272. https://doi.org/10.11250/chemotherapy1953.40.1263