Abstract
In order to determine the optimal dose of flucytosine (5-FC) in the treatment of fungi in the urine, we performed a dose-finding study. The patients were randomly assigned to receive 5-FC 2 g or 3 g (potency) for 7–14 days by the envelope method. Overall clinical efficacy was evaluated based on the criteria of the Japanese U TI Committee, with slight modification. The efficacy rates were 65.5% (19/29) for the 2 g group and 71.4% (15/21) for the 3g group, and the respective mycological eradication rates were 76.7% and 77.3%, with no statistically significant difference. Clinical adverse reactions were observed in 2.6% and 6.5% of the patients, respectively, with no statistically significant difference. Consequently, we believe that the optimal daily dose of flucytosine is 2 g (1 g b.i.d.) in the treatment of fungi in the urine.
Original language | English |
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Pages (from-to) | 1263-1272 |
Number of pages | 10 |
Journal | CHEMOTHERAPY |
Volume | 40 |
Issue number | 10 |
DOIs | |
Publication status | Published - Oct 1992 |
Externally published | Yes |
Keywords
- flucytosine
ASJC Scopus subject areas
- Pharmacology (medical)
- Infectious Diseases
- Pharmacology
- Drug Discovery
- Oncology