Doppler echocardiographic assessment of left ventricular diastolic function in chronic hypoxic rats

Atsushi Itoh, Hideshi Tomita, Shunji Sano

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Little information is available on the mechanism of diastolic left ventricular (LV) dysfunction in patients with chronic respiratory disease complicated by hypoxia. The purpose of this study was to investigate how chronic hypoxia impairs LV diastolic function in an hypoxic animal model. Thirty-six male Wistar rats 8 weeks old were assigned to normoxia (N), chronic hypoxia (CH), and re-normoxia (RN) groups, 12 rats per group. The N group rats were kept in ambient air for 8 weeks, while the CH group was kept hypoxic for 8 weeks. After 8 weeks of hypoxia the RN group rats were kept for a further 8 weeks in ambient air. LV systolic and diastolic functions, as well as right ventricular (RV) function, were analyzed using Doppler echocardiography; we also measured the hematocrit, and weighed the LV and RV. Hematocrit, RV weight/body weight, and RV weight/LV weight were higher in the CH group than in the other 2 groups. However, most of these parameters returned to normoxia levels after re-normoxia. In the CH group, LV dimension and area were smaller than in the other 2 groups. LV systolic function was preserved in all groups; however, in the CH group, mitral flow showed a restrictive pattern, while pulmonary flow demonstrated a pulmonary hypertensive pattern with prolonged RV ejection time. In conclusion, chronic hypoxia induced pulmonary hypertension and RV hypertrophy. Although LV systolic function was preserved, diastolic function was impaired in hypoxia. Ventricular interaction may impair LV diastolic function.

Original languageEnglish
Pages (from-to)87-96
Number of pages10
JournalActa Medica Okayama
Volume63
Issue number2
Publication statusPublished - May 2009

Fingerprint

Left Ventricular Function
Rats
Hematocrit
Weights and Measures
Echocardiography
Pulmonary diseases
Air
Hypoxia
Right Ventricular Hypertrophy
Right Ventricular Function
Lung
Animals
Doppler Echocardiography
Left Ventricular Dysfunction
Pulmonary Hypertension
Wistar Rats
Chronic Disease
Animal Models
Body Weight

Keywords

  • Chronic hypoxia
  • Left ventricular diastolic function
  • Pulmonary hypertension
  • Right ventricular hypertrophy
  • Ventricular interaction

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Doppler echocardiographic assessment of left ventricular diastolic function in chronic hypoxic rats. / Itoh, Atsushi; Tomita, Hideshi; Sano, Shunji.

In: Acta Medica Okayama, Vol. 63, No. 2, 05.2009, p. 87-96.

Research output: Contribution to journalArticle

Itoh, Atsushi ; Tomita, Hideshi ; Sano, Shunji. / Doppler echocardiographic assessment of left ventricular diastolic function in chronic hypoxic rats. In: Acta Medica Okayama. 2009 ; Vol. 63, No. 2. pp. 87-96.
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