Dopaminergic neuron-specific oxidative stress caused by dopamine itself

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

Oxidative stress, including the reactive oxygen or nitrogen species generated in the enzymatical oxidation or auto-oxidation of an excess amount of dopamine, is thought to play an important role in dopaminergic neurotoxicity. Dopamine and its metabolites containing 2 hydroxyl residues exert cytotoxicity in dopaminergic neuronal cells, primarily due to the generation of highly reactive dopamine and DOPA quinones. Dopamine and DOPA quinones may irreversibly alter protein function through the formation of 5-cysteinyl-catechols on the proteins. Furthermore, the quinone formation is closely linked to other representative hypotheses such as mitochondrial dysfunction, inflammation, oxidative stress, and dysfunction of the ubiquitin-proteasome system, in the pathogenesis of neurodegenerative diseases. Therefore, pathogenic effects of the dopamine quinone have recently focused on dopaminergic neuron-specific oxidative stress. In this article, we primarily review recent studies on the pathogenicity of quinone formation, in addition to several neuroprotective approaches against dopamine quinone-induced dysfunction of dopaminergic neurons. Copyright

Original languageEnglish
Article number1
JournalActa Medica Okayama
Volume62
Issue number3
Publication statusPublished - Jun 2008

Fingerprint

Oxidative stress
Dopaminergic Neurons
Neurons
Dopamine
Oxidative Stress
Quinones
Catechols
Neurodegenerative diseases
Reactive Nitrogen Species
Oxidation
Proteasome Endopeptidase Complex
Cytotoxicity
Metabolites
Ubiquitin
Neurodegenerative Diseases
Hydroxyl Radical
Virulence
Reactive Oxygen Species
Proteins
Inflammation

Keywords

  • Dopamine quinone
  • L-DOPA
  • Methamphetamine
  • Parkinson's disease
  • Quinoprotein

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Dopaminergic neuron-specific oxidative stress caused by dopamine itself. / Miyazaki, Ikuko; Asanuma, Masato.

In: Acta Medica Okayama, Vol. 62, No. 3, 1, 06.2008.

Research output: Contribution to journalArticle

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